73 results about "Intra bladder" patented technology

The invention discloses a catheter with real-time monitoring and alarming functions and a catheter system, and relates to the technical field of medical instruments, the catheter comprises a catheter main tube, a balloon, an interface, a pressure sensor and a flow sensor; the drainage tube, the flushing tube and the balloon tube penetrate through the inner space of the catheter handle; the drainage cavity electromagnetic valve is matched with the drainage tube penetrating through the catheter handle and is arranged on the catheter handle; the flushing cavity electromagnetic valve is matched with the flushing pipe penetrating through the catheter handle and is arranged on the catheter handle; the control module is used for judging the current normal urination or abnormal urination of the catheter according to the internal pressure of the bladder and / or the urine flow rate, and if the urination is judged to be normal, the drainage cavity electromagnetic valve is controlled to keep the drainage channel communicated; if it is judged that urination is abnormal, the abnormal type is determined by analyzing the internal pressure of the bladder and / or the urine flow rate, and processing including alarming is carried out according to the abnormal type.

An intelligent interactive neuromodulation system by intravesical and pelvic floor stimulation is provided, including: an electromyography (EMG) acquisition module, an intelligent diagnostic module, a display interaction module, and an electrical stimulation module. The intelligent diagnostic module is configured to receive an original EMG signal acquired by the EMG acquisition module and obtain feature information, generate a first treatment protocol by using the feature information and a preconfigured intelligent fitting model, and generate a classification result of an abnormal bladder activity based on the feature information and a preconfigured intelligent classification model; in response to identifying that a detrusor activity of a patient changes, automatically complete dynamic switching between a first treatment mode and a second treatment mode. The display interaction module is configured to receive a first treatment protocol and a second treatment protocol, and send the first treatment protocol to the electrical stimulation module to apply electrical stimulation pulses.

The application discloses a bladder tumor specimen extractor which comprises an adjusting transmission assembly capable of controlling preliminary cutting, a separating assembly capable of separating a tissue part and a liquid part of the bladder tumor and an operating handle. The application belongs to the technical field of bladder tumor surgery. When the bladder tumor temporarily stays on a tissue liquid passing layer, the removed bladder tumor can be punctured by a plurality of groups of puncture heads, so that the tissue part of the bladder tumor is blocked by the tissue liquid passing layer, and the tissue liquid and the plasma part of the bladder tumor can pass through the tissue liquid passing layer and enter a liquid storage bag. After sampling is completed, medical staff can take out the liquid storage bag to sample the tissue liquid and the plasma part of the bladder tumor, and the tissue part of the bladder tumor can be sampled from the tissue liquid passing layer. The application provides a brand-new bladder tumor sampling experience, greatly reduces the possibility of tissue liquid and plasma remaining in the bladder and brings convenience to medical staff.

The utility model discloses an anti-pulling catheter, and belongs to the technical field of medical instruments. Comprising an inner tube, an outer tube arranged outside the inner tube in a sleeving mode and an insertion body fixed to the head end of the inner tube and communicated with the inner tube, the outer tube and the inner tube are connected in a sealed mode to form a partition cavity, a balloon is arranged at the position, located at the partition cavity, of the outer tube, and a liquid injection tube is communicated with the interior of the balloon and penetrates out of the partition cavity; the inner tube comprises an end tube connected with an insertion body and a tail tube in the other direction, the end tube and the tail tube are in sealed communication connection through a connector structure, the connector structure is located in the balloon, and the connector structure is used for breaking connection between the end tube and the tail tube when being subjected to axial tension; when a user pulls the catheter accidentally, the end tube and the tail tube are disconnected at the connector structure, liquid in the balloon can enter the tail tube and be rapidly discharged from the tail tube, the balloon is shrunk, at the moment, the catheter cannot be left in the bladder or pulled out, and damage to the bladder and the urethra is prevented.

The utility model relates to the field of medical instruments, in particular to a visual reducing catheter which comprises a catheter body, one end of the catheter body is provided with a urine bag connector, and the other end of the catheter body is provided with a catheterization hole and a balloon used for limiting the catheterization hole in the bladder. A first connecting pipe and a second connecting pipe are arranged on the left side and the right side of the catheter body respectively, and a first charging connector and a second charging connector are arranged at the head of the first connecting pipe; a side air bag is sleeved on the catheter body between the balloon and the roots of the first connecting tube and the second connecting tube, the first inflating nozzle is communicated with the side air bag, and the second inflating nozzle is communicated with the balloon; a visual assembly is arranged on the second connecting pipe and used for monitoring and displaying the air pressure in the side air bag in real time. The catheter not only has a reducing function, but also has the function of monitoring the pressure of the ureter part entering the body of a patient in real time, visualization is achieved, and the pressure can be dynamically adjusted according to the actual requirements of the patient.

The present invention provides methods for treatment of high-risk non-muscle invasive bladder cancer that is unresponsive to BCG therapy by locally administering gemcitabine to the bladder. Also provided herein are kits and articles of manufacture for treating high-risk non-muscle invasive bladder cancer that is unresponsive to BCG.

Provided herein are therapeutic methods for use in treating bladder cancer, the therapeutic methods comprising administration of erdafitinib and drug delivery systems comprising erdafitinib.

The invention belongs to medical instruments, and particularly relates to a catheter which comprises a catheter body, a balloon, an imbedding unit and a first control line, the catheter body extends in the axial direction of the catheter body and is provided with a first cavity, and the first cavity is used for draining urine in the bladder; the balloon is installed on the catheter body, can expand and deform in the radial direction of the catheter body and is used for abutting against and being positioned on the bladder neck of the bladder; the imbedding unit is detachably connected to the catheter body and used for driving the catheter body and the balloon to be imbedded into the bladder; the first control line is connected with the catheter body, can penetrate through the imbedding unit and is used for driving the catheter body to be separated from the bladder. Therefore, the wearing comfort of a patient can be improved, the risk of urethritis and mucosal lesion is reduced, the catheter body can be conveniently pulled out, the urination disorder possibly occurring after the catheter is pulled out is prevented, the autonomous urination reflex function of the catheter is protected, and the urination disorder possibly occurring after the catheter is pulled out is effectively prevented.

The utility model discloses a catheter capable of displaying air bag pressure, which comprises a main body unit and a liquid injection unit, the main body unit comprises a catheter, an air bag is fixed on the outer side, close to the front end, of the catheter, a barrel is fixed on the outer side, close to the rear end, of the catheter, and an alarm lamp is mounted on the barrel. A connecting pipe is fixed and communicated to the position, close to the rear end, of the catheter, the liquid injection unit comprises a hollow plate fixed in the catheter, a liquid storage barrel is fixed to the catheter and communicated with the hollow plate, an L-shaped pipe is fixed and communicated to one end of the hollow plate, and the end, away from the hollow plate, of the L-shaped pipe penetrates through the catheter and is communicated with the interior of the air bag. The air bag extends into the bladder of a patient, then the air bag is expanded, the expanded air bag plays a role in fixing the catheter in the bladder of the patient, when the pressure in the bladder is increased, the air bag is extruded, liquid in the air bag extrudes the pressure sensor, an alarm is given through the alarm lamp, and medical workers are reminded to check.

The application provides a catheterization device with an adjusting function, comprising: a catheter, one end of the catheter is provided with a catheter head for guiding urine into the catheter head, and the other end of the catheter is provided with an adjusting switch body for adjusting the rate and on-off of the urine discharged from the other end of the catheter; a balloon, the balloon is arranged on the outer peripheral wall of the catheter close to the catheter head, and the balloon can be filled with a medium to fix the catheter in the bladder of a human patient; two electrodes with opposite polarities, one end of each of the two electrodes penetrates through the catheter and extends into the catheter head along the length direction of the catheter, and the two electrodes are respectively used for connecting the positive electrode and the negative electrode of an electrophysiological monitoring device at the end outside the catheter; wherein the catheter, the catheter head and the balloon are all made of an electrically charged silicone rubber material. The application accelerates the recovery of the self-urination ability of the patient and reduces the risk of urinary tract infection of the patient through the adjustment of the adjusting switch body and the electrodes.

The invention provides preparation of lipid nanoparticles and application of the lipid nanoparticles in bladder perfusion medicines, and belongs to the technical field of biological medicines. The lipid nanoparticle disclosed by the invention is prepared from ionic lipid, cholesterol, amphiphilic lipid and DOPE-LA, the ionic lipid is a cationic lipid or an ionizable lipid, the surface of the lipid nanoparticle (LANP) has a dithiolane structure, the lipid nanoparticle (LANP) can be subjected to a sulfydryl-disulfydryl exchange reaction with sulfydryl on the cell surface, and the LANP is adhered to the mucous membrane on the inner wall of the bladder in a chemical bond form so as to resist the reduction of the effective concentration of the drug caused by urine excretion.

The present disclosure generally relates to fluid therapy based on patient data, and associated systems, devices, and methods. Embodiments of the present technology can obtain multiple inputs of urine output volume data from a patient without using an indwelling catheter, determine an accumulated volume of urine output data based on the obtained multiple inputs, and adjust the patient's fluid therapy based on the accumulated volume and / or the obtained multiple inputs. Additionally, or alternatively, embodiments of the present technology can include one or more sensors that measure a volume and / or a change in volume of urine within the patient's bladder to determine a urine output rate of the patient, without using an indwelling catheter. Accordingly, embodiments of the present technology can advantageously manage a fluid therapy for patients that refuse an indwelling catheter.

The utility model discloses a bladder irrigator structure for blocking a urinary catheter by blood clots in blood, which belongs to the technical field of bladder irrigation and comprises auxiliary irrigation equipment, and the auxiliary irrigation equipment comprises a liquid storage tank and a storage tank; the flushing catheter comprises a catheter assembly, a non-return assembly is arranged in the catheter assembly, the catheter assembly comprises an input pipe, one end of the input pipe is communicated with the liquid storage tank, the other end of the input pipe is connected with an output pipe, the end of the output pipe is communicated with a connector, and the connector is connected with a catheter in the bladder of a patient. The outer side of the output pipe is communicated with the waste liquid pipe, and the end of the waste liquid pipe is communicated with the storage box, so that the waste liquid is effectively prevented from flowing back, the waste liquid is prevented from remaining and breeding bacteria at a gap between the side wall of the infusion pipe and the valve, and the risk of urinary system infection of a patient is greatly reduced.

The utility model relates to the technical field of ureter leading-in sheaths, solves the technical problem that a leading-in sheath cannot be limited in a urethra, and particularly relates to a ureter leading-in sheath with a bendable head end and a fixed balloon device, which comprises a protective tube serving as a supporting foundation, the inner side of the protection tube is provided with a limiting and steering assembly used for limiting and steering the guide-in sheath, the limiting and steering assembly is provided with a calculus discharging assembly used for discharging calculus broken stone, the limiting and steering assembly comprises a guide-out tube arranged on the inner side of the protection tube, and one end of the guide-out tube is connected with a limiting bag. Due to the arrangement of the limiting steering assembly, after the guiding-in sheath is inserted into the pelvis, the balloon is limited in the bladder by injecting water into the limiting bag, the stability of the guiding-in sheath in the urethra can be improved, and the fixing sheath can effectively reduce the pressure of the pelvis and reduce the risk of infection.

1. The name of the design product: bladder pressure monitoring device. 2. The use of the design product: used as monitoring bladder pressure. 3. The design features of the design product: in shape. 4. The picture or photo that best shows the design features: perspective view 1.

The invention relates to the technical field of medical instruments, and discloses a urinary catheterization device for urology department nursing and a using method thereof.The urinary catheterization device comprises a main body and further comprises a deviation rectifying mechanism, the deviation rectifying mechanism is installed on the outer surface of the main body, and movement of the deviation rectifying mechanism can reduce the bending situation of the top of the main body when water is injected into the main body. The drainage holes are circumferentially distributed, when liquid is injected into the balloon barrel, the liquid entering the balloon barrel can be evenly distributed, meanwhile, the inner walls of the first blocking plate and the second blocking plate on the outer wall of the balloon barrel make contact with each other, deformation of the balloon barrel can be blocked to a certain degree, and therefore the overall deformation of the balloon barrel is in a synchronous state; the condition that the main body in the bladder is extruded by the deformation of the balloon barrel to be bent due to the deformation of one side, close to the water injection hole, of the balloon barrel is reduced, so that the stability of the urinary catheterization device for nursing in the bladder is improved.

Intravesical devices are provided that are wholly deployable within the bladder of a patient in need of treatment and are well tolerated by the patient. The device may include an elastic body having a retention shape having (i) dimensions that provide intravesical mobility and that prevent voiding of the medical device through the urethra, and (ii) dimensions, buoyancy, or both, that exclude the medical device from entering the orifices of the ureters. The elastic body may exert a maximum acting force less than 1 N when compressed to a shape with a maximum dimension in any dimension of 3 cm. The device may include a drug for controlled release within the bladder, for treatment of the bladder or a regional tissue. Methods of treatment are also provided that include selecting a patient in need of treatment in the bladder where tolerability of the treatment is a primary concern.

The invention discloses a bladder tumor specimen extractor which comprises an adjusting transmission assembly capable of controlling preliminary dicing, a separating assembly capable of separating a tissue part and a liquid part of a bladder tumor and an operating handle. The invention belongs to the technical field of bladder tumor surgery. When the bladder tumor temporarily exists on the tissue fluid passing layer, the puncture heads can puncture the taken-down bladder tumor, so that the tissue part of the bladder tumor is blocked through the tissue fluid passing layer, and the tissue fluid and plasma part of the bladder tumor can penetrate through the tissue fluid passing layer and enter the fluid storage bag; medical staff can sample tissue fluid and plasma parts of the bladder tumor by taking down the fluid storage bag, the tissue part of the bladder tumor can be sampled from the tissue fluid passing layer, brand-new bladder tumor sampling experience is provided, the possibility that the tissue fluid and the plasma are left in the bladder is greatly reduced, and convenience is brought to the medical staff.

The invention relates to the technical field of biomedical administration, and particularly discloses double-layer hydrogel suitable for the interior of a bladder. The double-layer hydrogel comprises a hydrophilic adhesion slow-release layer and a hydrophobic protective layer; the hydrophilic adhesive slow-release layer and the hydrophobic protective layer are respectively obtained by curing a hydrophilic adhesive slow-release hydrogel precursor solution and a hydrophobic protective hydrogel precursor solution. By adopting a layered progressive double-hydrogel synergistic structure, an integrated administration barrier of mucous membrane adsorption-drug sustained release-physical protection is formed, so that the double-layer hydrogel has excellent bladder mucous membrane adhesion performance in a water environment and a stable and controllable drug sustained release effect, and the problems that an existing bladder perfusion drug is easily diluted and washed by urine, and the drug sustained release effect is poor are solved. The medicine action time is short, and the bioavailability is low.

This application belongs to the field of medical auxiliary devices, specifically relating to an auxiliary device for facilitating bladder irrigation, and more specifically to a positive pressure connector, an adapter connector, and a three-way valve. The three-way valve has a catheter connection end, a urine bag connection end, and an irrigation connection end on its valve seat, used to connect the catheter, urine bag, and irrigation infusion tubing, respectively. By rotating or pressing the valve core, the direction of fluid flow can be directly changed, simplifying the bladder irrigation operation. Simultaneously, a positive pressure connector is provided at the irrigation connection end to prevent bladder fluid from flowing out from the irrigation connection end due to accidental removal of the irrigation infusion tubing, such as when the valve core is not switched to the correct position.

The present disclosure relates to methods for treating bladder cancer in a patient in need thereof, comprising intravesically administering a pharmaceutical composition comprising a nucleic acid polyplex comprising (a) a dually derivatized chitosan and (b) a therapeutic nucleic acid construct encoding interleukin-12 (IL-12) and one or more RIG-I agonists, in one or more treatment cycles to the patient, wherein each treatment cycle comprises a first dose, a second dose administered at least 5-9 days after the first dose, a third dose administered at least 18-24 days after the second dose, and a fourth dose administered at least 5-9 days after the third dose; preferably wherein the pharmaceutical composition comprises from about 30 mg to about 50 mg, more preferably about 40 mg, of detalimogene voraplasmid.

The invention provides an intelligent bladder volume control method, device and equipment based on bladder pressure monitoring, belongs to the technical field of data processing, and aims to solve the problem of poor precision of keeping the current bladder volume constant, adaptive bladder diversion control can be carried out according to the urine increment rule of a target patient after drinking water, and the accuracy of bladder volume control is improved. The volume of urine in the bladder can be always kept within a certain interval, so that the pressure in the bladder can be prevented from being too high, and the keeping precision of the bladder capacity can be improved to a certain extent.

The application provides a drainage tube, and relates to the technical field of medical devices.The drainage tube comprises a main pipe, the inside of the main pipe is provided with a first channel, the front end of the main pipe is provided with an extensible elastic part, the rear end of the main pipe is provided with an operating mechanism, the operating mechanism passes through the first channel and is connected to the front end of the main pipe, and is used for switching the elastic part between a natural state and an inflation state under the action of external force.The operating mechanism has three states.In the first state, the elastic part is in the natural state, and the first channel is open.In the second state, the elastic part is in the inflation state, and the first channel is closed.In the third state, the elastic part is in the inflation state, and the first channel is open.Through the setting of the operating mechanism, the operating mechanism makes the elastic part form a lantern-shaped structure and is fixed in the bladder, the operating mechanism controls the opening and closing of the first channel while keeping the elastic part in the inflation state, and then the independent, step-by-step and controllable adjustment of the shape of the elastic part and the opening and closing state of the first channel is realized, so that diversified clinical requirements are met.

The invention discloses a simulation instrument for operation in a bladder, and belongs to the field of medical instruments, and the simulation instrument comprises a body cavity simulation structure which is internally provided with a closed simulation body cavity; the elastic simulation bladder is arranged in the simulation body cavity, a plurality of traction lines are arranged on the outer wall of the elastic simulation bladder, the other ends of the traction lines are fixed to the inner wall of the body cavity simulation structure, and when the elastic simulation bladder is in a natural state, the elastic simulation bladder is maintained at an initial position by the traction lines; the simulation bladder neck is connected to the inner wall of the simulation body cavity and provided with a first end facing the elastic simulation bladder, and the elastic simulation bladder is provided with a connecting port connected to the first end in a sleeving mode; the simulation telescopic urethra is connected to the outer wall of the body cavity simulation structure and provided with a second end part deviating from the elastic simulation bladder, and an operation channel communicated with the elastic simulation bladder is arranged between the first end part and the second end part in a penetrating mode. Through the arrangement, physical limitation of a body cavity on the bladder can be simulated, so that a prostate block in the bladder can be taken out conveniently.

The invention discloses a visual bladder irrigation and blood clot removal suit, and belongs to the technical field of urinary surgery medical equipment, the visual bladder irrigation and blood clot removal suit comprises a drainage mechanism, a visual mechanism is mounted in the drainage mechanism, the visual mechanism is used for identifying blood clots in the bladder, and a connecting mechanism is mounted at the top end of the drainage mechanism. By arranging the electric heating actuator, the temperature measuring assembly and the supply pump of the electric mechanism and the grabbing net bag, the inner traction rope, the tightening rope and other parts of the visual mechanism, the electric heating actuator and the temperature measuring assembly are matched to achieve precise control over the temperature of flushing fluid, and the supply pump can adjust the flushing speed; the grabbing net bag can accurately grab large blood clots under the driving of the inner traction rope and the tightening rope, due to multi-component linkage, spasm caused by the fact that cold flushing fluid stimulates the bladder is avoided, blood clots of different sizes can be efficiently removed, repeated operation is reduced, and through the synergistic effect of temperature control and accurate grabbing, large blood clots can be accurately grabbed. The problems of poor patient comfort and incomplete blood clot removal in the prior art are solved.

The need for improved drug delivery methods and systems for treating bladder cancer remains. It exists as such. [Solution] Gemcitabine is administered intravesically into the bladder of patients requiring treatment for bladder cancer, and then absorbed into the bladder tissue. A sustained concentration of gemcitabine sufficient to produce the above-mentioned therapeutically effective concentration By obtaining mucitabine in the urine of the bladder, the above patients can be administered gemcitabine. A drug delivery device and method are provided. In an embodiment, local delivery into the bladder of the patient. The administration is based on the average dose of gemcitabine (FBE) mentioned above, ranging from 1 mg / day to approximately 300 mg / day. That is the case.

Embodiments include systems and methods for treating diseases of the bladder, kidney, and urinary tract. The pharmaceutical product may be administered through the urethra in compacted form. Within the bladder, the product may expand or conform to a larger size, which prevents access into the urethra within a desired residence period. After the treatment period, at least a portion of the product may be dissolved or degraded such that individual particles excrete with urine. Embodiments also include drug particle delivery devices and methods of intravesical administration. The delivery device may use a drug-loaded cannula cartridge filled with a rod-like product that is administered into the bladder of a patient by actuation of a pressure source or a piston. The distal end of the barrel may be connected to a bladder sheath or a soft tip for direct insertion into the urethra of the patient.

The invention discloses a targeted drug delivery system in a bladder. The targeted drug delivery system comprises a reagent A and a reagent B, the reagent A is a biological micromotor, platelets are taken as a natural carrier, and streptavidin is bridged and coupled with biotinylation modified urease to serve as a driving component to entrap active components; the reagent B is a urea solution. According to the invention, the natural characteristics of platelet chemotaxis tumor inflammation microenvironment are utilized to realize specific enrichment of motors in a bladder tumor area; after urea perfusion, urease catalyzes urea to generate gas power to push the motor to move, meanwhile, compact extracellular matrixes are slightly loosened, the motor is assisted to penetrate and reach the interior of a tumor and release drugs, and the delivery efficiency and targeting performance of the drugs in the bladder are remarkably improved.

The utility model relates to the technical field of surgical instruments, in particular to a human body urinary tract inner diameter measuring instrument which comprises a measuring catheter and a rotating sleeve, the measuring catheter is of a hollow tube body structure, and one end of the measuring catheter is provided with a positioning bag cavity used for being fixed in a bladder. An air hole is formed in the position, located in the positioning bag cavity, of the measuring catheter, and the air hole is communicated with the positioning bag cavity and the measuring catheter; the rotating sleeve is arranged on the outer side surface of the measuring catheter in a sleeving mode, and a displacement sensor is arranged at the end, close to the positioning bag cavity, of the rotating sleeve. And a rotating sleeve is arranged at the other end of the rotating casing pipe, and the rotating sleeve is rotationally connected with the rotating casing pipe. The novel resectoscope effectively solves the problems that the existing resectoscope cannot adapt to differences of different races, so that the existing resectoscope cannot be used due to urethrostenosis in domestic operations or the urethra is easily damaged when the existing resectoscope is used, and the like.