163 results about "Intra bladder" patented technology

The present invention relates to compositions and methods for the administration of lipid-based vehicles to treat various disorders, including bladder inflammation, infection, dysfunction, and cancer. In various aspects, the compositions and methods of the invention are useful for prolonged delivery of drugs, e.g., antibiotics, pain treatments, and anticancer agents, to the bladder, genitourinary tract, gastrointestinal system, pulmonary system, and other organs or body systems. In particular, the present invention relates to liposome-based delivery of vanilloid compounds, such as resiniferatoxin, capsaicin, or tinyatoxin, and toxins, such as botulinum toxin, for the treatment of bladder conditions, including pain, inflammation, incontinence, and voiding dysfunction. Further related are methods of using these vehicles alone or in conjunction with antibodies, e.g., uroplakin antibodies, to improve duration of liposome attachment, and provide a long-term intravesical drug delivery platform. The present invention specifically relates to antibody-coated liposomes that are useful for targeting specific receptors for drug, peptide, polypeptide, or nucleic acid delivery. In one particular aspect, the present invention relates to liposomes coated with antibodies against nerve growth factor (NGF) receptor and containing NGF antisense nucleic acids, which are used as a treatment for neurogenic bladder dysfunction.

A belt is provided with an inflatable bladder which, when inflated, is permitted to expand toward an interior of the belt and prevented by a barrier from expanding toward an exterior of the belt. A pressure gauge indicates the pressure within the bladder, and the gauge is fixedly displaced relative to the belt and the user such that the gauge may be viewed by a user when the belt is worn without significantly moving the cervical spine substantially out of a neutral posture.

The present invention relates to a composition and method for treating cancer in the urinary bladder. More particularly, the present invention relates to a composition comprising a Mycobacterium phlei (M. phlei) deoxyribonucleic acid (M-DNA)-M. phlei cell wall complex (MCC), wherein the M-DNA is preserved and complexed on the M. phlei cell wall, and a pharmaceutically acceptable carrier. The MCC composition inhibits proliferation of and induces apoptosis in the cancer cells in the urinary bladder of the animal.

The invention discloses a bladder tumor cutter. The bladder tumor cutter comprises a connecting tube, a metal wire and a handle, wherein the wire is arranged inside the connecting tube in a penetrating mode; the handle is connected to the rear end of the connecting tube; the front end of the connecting tube is connected with a collecting bag; the front end of the metal wire is connected onto the circumference of the opening of the collecting bag, and a part of the metal wire, which is positioned on the front edge of the opening of the collecting bag, is exposed to serve as an electric cutting wire; the handle comprises a columnar handle body, which is provided with a traction member, and the traction member is provided with a power line; the two ends at the rear end of the metal wire penetrate out of the handle body via the side walls of the handle body and are connected with the power line. The bladder tumor cutter can integrally cut off and collecting tumors in different positions and sizes in bladder through the metal wire and the collecting bag, thereby effectively reducing amount of bleeding during surgery, avoiding tumor floating, ensuring a clear operative view field, shortening the surgical time and greatly lowering the difficulty in tumor excision as well as the risks of tumor recurrence.

Disclosed is an anti-blockage urinary catheter, comprising a catheter body (1) and a balloon (2), wherein the balloon is provided on the catheter body at a site close to the tail end and the balloon is provided with a filter net (3) outside, wherein the filter net coats the tail end of the catheter body and is ovoid when in the open state. After placing the urinary catheter into the bladder, air is inflated into the balloon or water is injected into the balloon, in order to fully open the balloon and stretch the filter net to contact with the liquid in the bladder in the maximum area, thus preventing the bladder from bleeding to form blood clots, bladder stones and bladder mucosa to block the pipe orifice thus leading to overactive bladder filling.

The invention discloses a simple urine leakage prevention water bag valve urethral catheter, which belongs to a medical instrument. According to the urethral catheter, a circle of skirt-shaped valve is newly and additionally arranged above a common water bag urethral catheter water bag to realize leakage prevention. The skirt-shaped valve is shrunk and attached to the urethral catheter water bag part at a production stage by means of a special process or adhesion action; after the urethral catheter is determined to enter the bladder in use, water is injected from a water injection port of the water bag, and the skirt-shaped valve is expanded along with water injection of the water bag to be opened and be separated from the original water bag; the skirt valve is attached to the neck of the bladder by means of pressure of the water bag and internal pressure of the bladder just like a piece of thin film covering the water outlet; no matter whether the urethral catheter is closely attached to the urethra, the skirt valve has a seepage blocking effect on the neck of the bladder; and even if the bladder of a patient is actively or non-actively (stimulated) shrunk, the valve is more closely pressed around the neck of the bladder when the pressure of the bladder increases, no dead space exists, the seepage of urine around the urethral catheter can be effectively prevented, and reverse infection is prevented. The urethral catheter is easy and convenient to operate; and compared with the conventional urine catheterization, the workload is not increased.

The invention discloses a four-chamber double-balloon urinary catheter. The four-chamber double-balloon urinary catheter comprises a catheter pipeline, balloons and catheter chambers. The front end of the catheter pipeline is provided with the two balloons which are arranged in a front-back mode, and the four catheter chambers are arranged inside the catheter pipeline. An intra-bladder balloon and a prostate balloon form the two balloons; two of the four chambers are balloon inflation chamber channels, one of the rest two chambers is an intra-bladder urination channel, and the remaining chamber is an analgesic or anti-infective drug feeding channel. According to the four-chamber double-balloon urinary catheter, the prostate balloon is a high-capacity low-pressure balloon and can compress the wound of prostate surgery after being filled with gas or liquid to achieve the aim of hemostasis through direct compression. One additional catheter chamber of the four catheter chambers is arranged behind the prostate balloon and is used for filling local anesthetic to stop pain or other medicines to prevent infection. Besides, the four-chamber double-balloon urinary catheter is simple in structure and convenient to operate and has excellent performance.

The invention discloses a method for treating bladder cancer through promoting pharmorubicin by a bacillus calmette guerin vaccine (BCG), and specifically relates to the field of combined treatment ofthe bladder cancer in clinical medicine. The method comprises a method for researching synergism of the BCG to the pharmorubicin in a cellular level and a method for synergism of the in-vivo BCG to the pharmorubicin. According to the invention, through using the method for researching the synergism of the BCG to the pharmorubicin in the cellular level and the method for the synergism of the in-vivo BCG to the pharmorubicin, a combined medication scheme is provided to improve treatment efficiency and reduce toxic and side effects during drug perfusion. The method disclosed by the invention isnot high in prefused drug concentration, but long in intra-bladder retention time, thereby being better in the anti-tumor effect without generating an adverse reaction.

The invention provides an underwater shaving system capable of avoiding bladder damage and a use method. The system comprises a shaving main body system and a liquid pressure sensor system, wherein the shaving main body system comprises a shaving cutter head and a control device for controlling the shaving cutter head to work; the liquid pressure sensor system is in signal connection with the control device and is used for sensing liquid pressure information in a bladder, and when the liquid pressure information is lower than a preset threshold, the control device controls the shaving cutter head to stop shaving and cutting actions. According to the underwater shaving system, the occurrence probability of an accident that the bladder is accidentally injured during prostatectomy can be greatly reduced.

The invention discloses a bladder drug delivery device for the department of medical oncology, and belongs to the technical field of medical instruments. The bladder drug delivery device comprises a urethral catheter and a liquid discharge port, wherein a liquid discharge tube head is formed at the rear end of the urethral catheter, a drug delivery port is formed in the front end of the urethral catheter, a drug delivery tube head is formed at the rear end of the urethral catheter, an elastic film is formed at the front end of the urethral catheter, an elastic connecting ring is formed at thetail end of the elastic film, a plurality of elastic supporting rods are fixedly connected with the outer side of the elastic film, the urethral catheter is provided with an expanding part capable ofenabling the front ends of the elastic supporting rods to move towards the outer side, and the elastic film can be unfolded to abut against the inner wall of the bladder to isolate the bladder from urine. According to the bladder drug delivery device, a drug or cleaning liquid can directly act on the inner wall of the bladder, an anti-falling air bag is arranged, and thereby the urethral cathetercan be prevented from accidentally sliding out of the body in the intubation process. Part of the bladder can be isolated from urine, and thereby a liquid medicine cannot be diluted when the bladder is directly administrated or cleaned, so that the full exertion of the medicine effect is facilitated, the treatment speed of a patient is increased, and the pain of the patient is relieved.

The invention provides a urethral canal pressure measuring pipe, a pressure measuring device and a fluid form resistance measuring device. The pressure measuring pipe comprises a filling cavity, threepressure measuring cavities and four channels arranged integrally, and open holes corresponding to corresponding positions of a human body. In four channel ports of the first end of the pressure measuring pipe, a filling cavity channel port is used for connecting with a filling pump, and three pressure measuring cavity channel ports are used for connecting with a pressure sensor respectively; after the pressure measuring pipe stretches into a preset position of a urethral canal of the human body, the open hole of the filling cavity is located on the most tail end of the pressure measuring pipe and is located in a bladder of the human body; the open holes of the three pressure measuring cavities are respectively located in the bladder of the human body, the lower end of prostate and a position which is 2+ / -0.5cm far away from an in-vitro urethral canal outlet of the human body; each urethral canal fluid form resistance is calculated according to a formula as shown in the description, so that a urethral canal obstruction type and a prostate obstruction degree can be conveniently evaluated.

The invention relates to an endoscope and lithotripsy all-in-one device for the urinary system. The endoscope and lithotripsy all-in-one device for the urinary system comprises a light source, a light transmitting optical fiber channel, an imaging optical fiber channel, a lithotripsy assembly channel, an image transmitting optical fiber and an image display device. The light transmitting optical fiber channel, the imaging optical fiber channel and the lithotripsy assembly channel are all arranged in sheaths. The sheaths comprise the sheath I and the sheath II which are hinged to each other. Two sliding grooves which are arranged axially are symmetrically formed in the outer wall of the sheath I. An endoscope further comprises a swinging driving device. The swinging driving device is used for controlling the sheath II 4 to swing at the far end. According to the endoscope and lithotripsy all-in-one device for the urinary system, the lithotripsy end of the endoscope and lithotripsy all-in-one device can be bent to different degrees according to needs, the endoscope and lithotripsy all-in-one device is suitable for the diagnosis and treatment of stone in any part of the bladder, no blind area exists in the version in the bladder, the defect of an existing bladder lithotriptoscope is overcome, the application range of the bladder lithotriptoscope is remarkably broadened, the residual rate of the bladder stone is lowered, the pain of a patient is relieved, and the burden of the patient is lightened.

The invention discloses a perfusion type bladder bacterial biofilm dynamic incubation simulation system and belongs to the technical field of bacterial biofilm incubation systems. The perfusion type bladder bacterial biofilm dynamic incubation simulation system comprises a urine storage device, a peristaltic pump, an incubation box, a urine collector and connecting pipes, wherein the urine storage device, the peristaltic pump, the incubation box and the urine collector are sequentially connected through the connecting pipes; the incubation box comprises a box body and a box cover connected with the box body, a liquid inlet and a liquid outlet are respectively formed in two sides of the box body, the liquid inlet is connected with the outlet of the peristaltic pump through one connecting pipe, and the liquid outlet is connected with the urine collector through one connecting pipe. The perfusion type bladder bacterial biofilm dynamic incubation simulation system has the advantages that persistence and variability of the simulation of incubation conditions of an environment in the bladder are achieved, and dynamicity and diversification of experiment intervention measures become possible.

Therapeutic compositions comprising an indoloquinone compound and various bladder cancer treatments and methods are disclosed. More specifically, bladder cancer treatments include the intravesical administration of apaziquone immediately following transurethral resection. Also disclosed are therapeutic compositions comprising an indoloquinone compound and a formulation vehicle. The formulation vehicle improves the solubility and stability of the indoloquinone compound. Additionally, the coating compositions can include coating agents that provide better adhesion of the coating composition to the bladder wall during intravesical delivery of the coating composition.

The invention discloses a urinary tube structure and a method for exercising urination function. The urinary tube structure comprises: a urinary catheter, a urethral stimulation electrode and a control module; wherein a first end of the urinary catheter is set in the bladder, a second end of the urinary catheter extends from the bladder through the urethra to the outside, the first end is providedwith a urine inlet and a first pressure sensor, and the first pressure sensor is used for detecting pressure change of urine in the bladder; the urethral stimulation electrode is arranged on a side wall of the urinary catheter positioned in the urethra and used for generating a stimulating electrode for the urethra; and the control module is electrically connected with the first pressure sensor and the urethral stimulation electrode at the same time, the first pressure sensor detects urine pressure change data in the bladder and transmits the pressure change data to a controller, and the control module controls the urethral stimulation electrode to generate electrical stimulation to the urethra so as to exercise the urination function. The urinary tube structure can stimulate urethral sphincter of a patient while the patient is passively urinating to exercise the urination function of the patient.

The subject of the invention is a ureteral stent. The invention discloses a ureteral stent that includes a tubular member and a retaining end adapted to be placed inside a kidney or a bladder of a patient. The retaining end includes a plurality of loops. Each of the loops is centered about a loop axis, and two or more of the loop axes extend in different directions relative to other loop axes.

The invention belongs to the technical field of medicines, and particularly relates to a nano-drug based on stem cells as well as a preparation method and application of the nano-drug. The invention provides a nano-drug based on stem cells. The nano-drug comprises a stem cell conditioned medium, a carrier material and polycations; the carrier material is used for wrapping the stem cell conditioned culture medium to form nanoparticles; the polycations are modified on the surfaces of the nanoparticles. The invention provides a nano-drug based on stem cells as well as a preparation method and application of the nano-drug, and effectively overcomes the technical defects that a drug is easily diluted by urine, is discharged along with the urine, is short in residence time and is difficult to penetrate through a bladder mucosal barrier when the drug is applied in the bladder to treat bladder diseases in the prior art.

Provided is a pharmaceutical composition for use in a method of preventing or treating a urinary tract infection (UTI), chronic cystitis, overactive bladder, partial bladder obstruction or urethritis, said composition comprising one or more oligomeric tannins, selected from proanthocyanidins and / or hydrolysable tannins, where in said method said composition is administered intraurethrally, intravesically, intraureterally and / or intrarenally, as well as a pharmaceutical composition for use in a method of preventing or treating bladder cancer, where in said method said composition is administered intravesically, said composition comprising one or more oligomeric tannins, selected from proanthocyanidins and / or hydrolysable tannins, wherein said tannins are bound to an anti-cancer agent and / or liposomes containing an anti-cancer agent, together with compositions related thereto.

The invention provides a novel transurethral bladder tumor electrocision electrode with a hook-shaped structure. The electrocision electrode comprises a urethral catheter which is smooth in appearanceand free of sharp protruding structures, a sight glass tube and an electrode catheter are arranged in the urethral catheter, an indwelling device sleeving the outer wall of the electrode catheter isarranged in the urethral catheter, and the electrode catheter is slidably connected to the indwelling device through a sliding way; hollow bearings are symmetrically fixed to the two ends of the interior of the electrode catheter, a cable catheter penetrates through the interior of each of the two sets of bearings, and the end, placed in the bladder, of the cable catheter is connected to an electrocision electrode of a hook-shaped structure; the electrocision electrode is convenient to rotate and adjust in the angle direction, the urethral catheter is stably attached to the urethra in the adjusting process, and damage of the catheter to the urethral wall is reduced; and the electrocision electrode is of a hook-shaped structure, the contact surface between the electrocision electrode and atumor is reduced, burn damage to the inner wall of the bladder is reduced during electrocision, the hook end of the hook-shaped structure can lift and tear the tumor to separate the tumor from the inner wall of the bladder, and the electrocision electrode is convenient to use.

The invention relates to a bendable and stretchable bladder endoscope which comprises a light source, a light transmission optical fiber, an imaging optical fiber, an image transmission optical fiber and an image display device. The imaging optical fiber and the light transmission optical fiber are both arranged inside sheath tubes, the sheath tubes comprise the sheath tube I and the sheath tube II which are mutually hinged, and two sliding chutes which are formed in the axial direction are symmetrically formed in the outer wall of the sheath tube I. The endoscope further comprises a swing driving device, and the swing driving device is used for controlling swing of the sheath tube II 4 in a far-end mode. The head of the bladder endoscope can swing in varying degrees according to needs, the bladder endoscope can be suitable for diagnosing any part in a bladder, a non-blind area view can be achieved in the bladder, the defects of an existing bladder endoscope are overcome, the definite diagnosis rate of the bladder endoscope is obviously improved, the adjusting manner is a pure mechanical principle adjusting manner, energy can also be saved, the complexity of the device is lowered, and feasibility is increased.

The invention relates to the technical field of medical instruments, in particular to an artificial urethra and an artificial urethra implantation kit. The artificial urethra comprises a tube body, a first positioning piece and a second positioning piece; the tube body is provided with an inner cavity which is used for guiding urine to flow; the first positioning piece is connected to one end of the tube body, and the first positioning piece can be positioned in the bladder; the second positioning piece is connected to the tube body, and the second positioning piece can be positioned on a ball urethra; and after the artificial urethra is implanted into a human body, urine can be discharged through the inner cavity. The artificial urethra can be placed in the urethra for a long time and does not slip out of the human body, and therefore surgical operation can be avoided.

Devices that are placed within fluid filled organs, such as the bladder, which reduce the risk of bacterial infections using a combination of active agents and mechanical disruption of bacteria.

The present invention discloses a multifunctional single-guide indwelling urethral catheterization and drainage device. The multifunctional single-guide indwelling urethral catheterization and drainage device comprises a body-entering pipe, the body-entering pipe is internally provided with an air bag, the body-entering pipe is internally provided with an air inflation cavity, a liquid injection cavity, a liquid discharge cavity and a urethral catheterization cavity, one end of the body-entering pipe is provided with an end head, the end head is internally provided with arc-shaped liquid injection cavities and arc-shaped liquid discharge cavities, the other end of the body-entering pipe is connected with a liquid injection pipe, a liquid discharge pipe and an air inflation pipe, a urethralcatheterization pipe is arranged in the urethral catheterization cavity, one end of the urethral catheterization pipe is provided with an inductor, the other end of the urethral catheterization pipeis provided with a urine collection bottle, one end, close to the urine collection bottle, of the urethral catheterization pipe is provided with a side pipe and a urethral catheterization valve, the side pipe is provided with a sealing cover, the air inflation pipe is provided with an air inflation valve, the liquid injection pipe is provided with a liquid injection valve, the liquid discharge pipe is provided with a liquid discharge valve, and an electric wire passes through the side pipe and is connected with the inductor. By adopting the structure, the device improves cleanness during urinedrainage and bladder flushing, at the same time facilitates measurement of core body temperatures, intravesical pressure and urine volume, avoids infection caused by repeated operation and is more convenient to operate and high in practicability.

The invention relates to the technical field of medical instruments, in particular to a urinary surgery nursing device without urine leakage. The device comprises a surgery nursing device main body, the surgery nursing device main body comprises a surgery nursing device body, the top end of the surgery nursing device body is provided with a dirt feeding hopper, an air isolation mechanism is fixedly installed on the outer side of the dirt feeding hopper and the air isolation mechanism comprises a first connecting plate. According to the device, by arranging clamping plates, due to the fact thatthe clamping plates are of an arc-shaped structure in appearance, meanwhile, a rubber pad is glued to one side of each clamping plate, the situation that a male genital organ is injured to a certainextent due to the fact that the clamping force of the two clamping plates on the male genital organ is too large is prevented, the outer side of a guiding urination catheter absorbs a certain amount of lubricant, the guiding urination catheter is matched with the lubricant and inserted into a bladder through the male genital organ, therefore, urine in the male bladder is guided out, and the phenomenon that the urine overflows is prevented.

The invention relates to a cystostomy drainage device capable of measuring pressure and warning. The drainage device comprises a stoma tube, a disc body is connected with the tube tail of the stoma tube, the stoma tube is provided with a drainage channel, the drainage channel is provided with a horizontal opening at the tube head, a clamping air bag is arranged outside the tube wall at the front end of the stoma tube, a long seal air bag is arranged outside the tube wall on the middle section of the stoma tube, and a pressure sensor is arranged in the horizontal opening at the tube head of the stoma tube in an attached mode; the disc body is of a hollow structure, a hollow cavity of the disc body is internally provided with a pressure control and collection module and a power supply module, the upper end surface of the disk body is provided with a pressure displayer, an alarm apparatus, a clamping air bag gas injection hole and a long seal air bag gas injection hole, and a urination opening is formed in the side wall of the disc body. By means of the device, bladder pressure measuring and alarming can be conducted, when the pressure in the bladder is within a safe range, urine can be stored in the bladder, when the urine pressure in the bladder is out of the safe range, the pressure control and collection module controls the alarm apparatus to give an alarm, and then a patient can open the urination opening for urination.

The invention relates to the technical field of medical devices, in particular to a urethral catheterization assistance device for transurethral resection surgery for bladder tumor. The device comprises a catheter and an assistance mechanism for coordinating with the catheter in insertion. The catheter comprises a flushing cavity and a drainage cavity which are two completely separated cavities bya partition, a flushing cavity inlet and a flushing cavity outlet are formed in two ends of the flushing cavity respectively, and a drainage cavity inlet and a drainage cavity outlet are formed in two ends of the drainage cavity respectively. An internal capsule and an external capsule are arranged on the catheter, an opening is formed in a position, corresponding to a cavity of the inner capsule, of the catheter, and the opening is connected to the tail end of the catheter through a hose. The device can effectively prevent blood stasis in the bladder, clears an ideal operation field for surgeons, and facilitates rapid electrocoagulation of a bleeding position in the bladder base or villi; and the bladder can be cleaned at any time, repeated intubation for catheterization and cleaning isprevented, and injuries and infection to urethrae are prevented.

The invention relates to the technical field of medical instruments, in particular to a urethral catheterization device capable of achieving automatic blocking. A urine guiding head extends into a bladder of the human body, a urine guiding pipe is communicated with the urine guiding head, urine in the human body is guided out, a three-way connector is communicated with the end of the urine guiding pipe, the pressure transmitting pipe and the urine bag assembly are communicated with the three-way connector, a urine bag assembly is used for collecting urine, and the detection assembly controls the pressure transmitting pipe to only allow air to flow and enter a sampling bottle. The detection assembly judges the change of the content of urine in the bladder of the human body according to the change of the air pressure in the detection sampling bottle, when the air pressure is increased to a set value, it is proved that the urine content reaches the set value, then the detection assembly controls the urine bag assembly to be opened and collect urine, and after the urine bag assembly is opened for a certain time, the urine bag assembly is automatically controlled to be blocked. the reflectivity of the bladder of the patient can be trained; by adopting automatic opening and closing, the nursing burden is reduced, and the manual labor force is saved.

The invention belongs to the field of biological medicines, and relates to a bladder irrigation solution which is used for treating the effective concentration of nonbacterial cystitis, is in contact with the internal surface epithelium and relevant structures of the bladder of a patient suffering from the nonbacterial cystitis to prevent and treat the nonbacterial cystitis and contains sodium hyaluronate. The bladder irrigation solution comprises a water-soluble mucous membrane adhesive material, an active component and a medically acceptable carrier and / or an additive. The water-soluble mucous membrane adhesive material is prepared from hyaluronic acid-cysteine and salt thereof, and the molecular weight is not less than 50,000 Dalton, and the use amount is smaller than 1 percent; the active component comprises glycosaminoglycan and / or amino monosaccharide; glycosaminoglycan is one or a combination of several of salt, chondroitin sulfate and dermatan sulfate of any proportion; amino monosaccharide is a combination of one or two of glucosamine and acetylglucosamine of any proportion. The irrigation solution contains the medically acceptable carrier and / or an additive which comprises an osmotic pressure adjusting agent, a pH adjusting agent, a preservative and water.