The present invention discloses a multifunctional single-guide indwelling urethral catheterization and drainage device. The multifunctional single-guide indwelling urethral catheterization and drainage device comprises a body-entering pipe, the body-entering pipe is internally provided with an air bag, the body-entering pipe is internally provided with an air inflation cavity, a liquid injection cavity, a liquid discharge cavity and a urethral catheterization cavity, one end of the body-entering pipe is provided with an end head, the end head is internally provided with arc-shaped liquid injection cavities and arc-shaped liquid discharge cavities, the other end of the body-entering pipe is connected with a liquid injection pipe, a liquid discharge pipe and an air inflation pipe, a urethralcatheterization pipe is arranged in the urethral catheterization cavity, one end of the urethral catheterization pipe is provided with an inductor, the other end of the urethral catheterization pipeis provided with a urine collection bottle, one end, close to the urine collection bottle, of the urethral catheterization pipe is provided with a side pipe and a urethral catheterization valve, the side pipe is provided with a sealing cover, the air inflation pipe is provided with an air inflation valve, the liquid injection pipe is provided with a liquid injection valve, the liquid discharge pipe is provided with a liquid discharge valve, and an electric wire passes through the side pipe and is connected with the inductor. By adopting the structure, the device improves cleanness during urinedrainage and bladder flushing, at the same time facilitates measurement of core body temperatures, intravesical pressure and urine volume, avoids infection caused by repeated operation and is more convenient to operate and high in practicability.