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An implant and its preparation method and application

A technology of implants and mixtures, applied in the field of implants, can solve problems such as repeated infections, infection lesions that cannot be eradicated, and little effect

Active Publication Date: 2022-08-09
ZHUJIANG HOSPITAL SOUTHERN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although a variety of antibiotics and antibacterial drugs can theoretically be used to combat implant-related infections, because bacteria can form dense biofilms on the surface of implants, biofilms can block the action of drugs (including antibiotics, antibacterial drugs, etc.) effect, which in turn leads to the inability to eradicate the infected lesions, resulting in repeated infections
[0003] In the past few decades, researchers have used various methods to combat biofilms, such as the combination of multiple antibiotics, such as combining drugs that target the mechanism of biofilm formation, and for example, drug delivery through the circulatory system or on the surface of implants. Drug release coating or heavy metal coating; but the above methods have little effect due to the strong resistance of bacteria in the biofilm

Method used

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  • An implant and its preparation method and application
  • An implant and its preparation method and application
  • An implant and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0099] The present embodiment prepares a kind of implant, and the specific process is:

[0100] D1. Polish and ultrasonically clean the titanium-based raw material, then place the titanium-based raw material in deionized water, ultrasonically clean it for 5 minutes, repeat three times, and air dry;

[0101] D2. Alkaline etching is performed on the titanium-based raw material obtained in step D1. The etching solution contains 4 mol / L potassium hydroxide; the reaction condition is 70° C.; the reaction time is 3 h; For deionized water, repeat three times to obtain a titanium-based substrate;

[0102] D3. get curcumin and be dispersed in deionized water to make 300 μg / mL curcumin suspension, adjust the pH of suspension to be 9, place above-mentioned suspension on magnetic stirrer and stir at uniform speed for 24h to make curcumin nanoparticle, after The particle size measured by DLS (dynamic scattering) and TEM is 150±30nm (the particle size is distributed in this range);

[010...

Embodiment 2

[0107] The present embodiment prepares a kind of implant, and the specific process is:

[0108]D1. Polish and ultrasonically clean the titanium-based raw material; after that, place the titanium-based raw material in deionized water, ultrasonically clean for 5 minutes, repeat three times, and air dry;

[0109] D2. Alkaline etching is performed on the titanium-based raw material obtained in step D1. The etching solution contains 10 mol / L potassium hydroxide; the reaction condition is 70° C.; the reaction time is 3 h; For deionized water, repeat three times to obtain a titanium-based substrate;

[0110] D3. get curcumin and disperse it in deionized water to make a curcumin suspension of 600 μg / mL, adjust the pH of the suspension to be 8, place the above-mentioned suspension on a magnetic stirrer and stir at a uniform speed for 24h to make curcumin nanoparticles. The particle size measured by DLS (dynamic scattering) and TEM is 650±50nm (the particle size is distributed in this ...

Embodiment 3

[0115] The present embodiment prepares a kind of implant, and the specific process is:

[0116] D1. Polish and ultrasonically clean the titanium-based raw material; after that, place the titanium-based raw material in deionized water, ultrasonically clean for 5 minutes, repeat three times, and air dry;

[0117] D2. Alkaline etching is performed on the titanium-based raw material obtained in step D1. The etching solution contains 10 mol / L potassium hydroxide; the reaction condition is 70° C.; the reaction time is 3 h; For deionized water, repeat three times to obtain a titanium-based substrate;

[0118] D3. get curcumin and disperse it in deionized water to make 50 μg / mL curcumin suspension, adjust the pH of the suspension to be 7, place the above suspension on a magnetic stirrer and stir at a uniform speed for 24h to make curcumin nanoparticles. The particle size measured by DLS (dynamic scattering) and TEM is 60±5nm (the particle size is distributed in this range);

[0119]...

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Abstract

The invention discloses an implant and its preparation method and application. An implant, comprising: a titanium base; an intermediate coating; the intermediate coating is applied on the surface of the titanium base; the components include arginine and polydopamine; a sound-sensitive coating, the sound-sensitive The coating is coated on the surface of the intermediate coating; the components include a binder and sound-sensitive particles; the sound-sensitive particles have a core-shell structure, the core includes curcumin particles, and the shell includes polydopamine. The implant of the present invention can solve the stubborn biofilm formed by bacteria on the surface of the implant due to the cooperation of various components.

Description

technical field [0001] The invention belongs to the technical field of implants, and in particular relates to an implant and a preparation method and application thereof. Background technique [0002] With the advancement of medicine, the clinical application of implants is also increasing, but infection related to implants is still a key problem that plagues implantation surgery. Although a variety of antibiotics and antibacterial drugs can theoretically be used to combat implant-related infections, because bacteria can form dense biofilms on the surface of implants, biofilms can block the action of drugs (including antibiotics, antibacterials, etc.) effect, which in turn leads to the inability to eradicate the infection foci, resulting in repeated infections. [0003] Over the past few decades, researchers have used a variety of methods to combat biofilms, such as the combination of multiple antibiotics, such as the combination of drugs targeting the mechanism of biofilm ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/10A61L31/02A61L31/16
CPCA61L31/022A61L31/10A61L31/16A61L2300/216A61L2300/624A61L2300/606A61L2300/404C08L79/04
Inventor 侯鸿浩于博蔺汝荣颜冰陈彦
Owner ZHUJIANG HOSPITAL SOUTHERN MEDICAL UNIV