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Preparation method of sesamol

A technology of sesamol and diphenol, applied in the field of compound synthesis, can solve problems such as low yield, and achieve the effects of simple process and low cost of raw materials

Pending Publication Date: 2021-11-19
重庆化工职业学院
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, adopting these two methods to synthesize sesamol, the yield is relatively low, about 60%

Method used

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  • Preparation method of sesamol
  • Preparation method of sesamol
  • Preparation method of sesamol

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Embodiment 1

[0027] The preparation of sesamol, concrete steps are as follows:

[0028] (1) Synthesis of 2-chloro-1,4-diphenol

[0029] Weigh 11.01g (0.10mol) of p-diphenol and 2.80g (0.05mol) of reduced iron powder and place them in a 500mL round bottom flask, and add 150mL of carbon tetrachloride to the round bottom flask, and magnetically stir to fully dissolve; Heat to boiling, and under the irradiation of ultraviolet light source, slowly introduce 0.40mL chlorine gas at a uniform speed; White crystals precipitated, filtered (recovering carbon tetrachloride in the filtrate), collected the filter residue and recrystallized the filter residue with acetone to obtain 13.54g of white crystal 2-chloro-1,4-diphenol, namely 2-chloro-1,4- The yield of diphenol is 93.6%.

[0030] (2) Synthesis of 1,2,4-triphenol

[0031] Weigh 14.46g (0.10mol) of 2-chloro-1,4-diphenol and 6.0g of sodium hydroxide solid (0.15mol) into a 500mL round-bottomed flask, and add 150mL of distilled water to the flask,...

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Abstract

The invention belongs to the technical field of compound synthesis, and particularly relates to a preparation method of sesamol, wherein the preparation method comprises the steps: firstly, preparing 2-chloro-1,4-diphenol by using p-diphenol and chlorine as raw materials, then reacting the 2-chloro-1,4-diphenol with a sodium hydroxide aqueous solution to obtain 1,2,4-trisphenol, and finally reacting the 1,2,4-trisphenol with dichloromethane to obtain the sesamol. The invention provides a new way for preparing sesamol, and the yield of sesamol is obviously improved.

Description

technical field [0001] The invention belongs to the technical field of compound synthesis, and in particular relates to a preparation method of sesamol. Background technique [0002] The chemical name of sesamol is 3,4-methylenedioxyphenol, and the molecular formula is C 7 h 6 o 3 , the structural formula is It is a natural fat-soluble lignan compound present in sesame oil (Chen Jinying, Luo Zhongming. Study on the stability of sesamol [J]. Food Research and Development, 2015, 36(4): 14-18; Ren Xiaona, Zeng Jun. Research status of lignans in sesame [J]. Food Industry Science and Technology, 2014, 35(1):383-386). [0003] Sesamol is the main component of sesame oil, and it is also the component that makes sesame oil have a special fragrance. Sesamol can make the quality of sesame oil more stable, and it also has antibacterial, anti-inflammatory, anti-oxidation, anti-melanin, anti-aging, anti-cancer, neuroprotective, weight loss and other effects (Ma Congcong, Xu Jicui, ...

Claims

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Application Information

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IPC IPC(8): C07D317/64
CPCC07D317/64
Inventor 周石洋陈本寿
Owner 重庆化工职业学院
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