Novel applications of inulin

A new use, the technology of inulin, applied in the field of inulin research, can solve the problems of obtaining significant curative effect and so on

Active Publication Date: 2021-11-23
XIEHE HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI & TECH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, none of these preparations have achieved significant efficacy in clinical trials

Method used

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  • Novel applications of inulin
  • Novel applications of inulin
  • Novel applications of inulin

Examples

Experimental program
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Embodiment Construction

[0069] The first aspect of this part describes some uses of the invention:

[0070] New uses of inulin, wherein the new uses are at least one of the following

[0071] (i) the application of inulin in the preparation of cells expressing and secreting MMP2 and / or MMP9 inhibitors, preferably the cells are T cells or macrophages,

[0072] (ii) the use of inulin in the preparation of inhibitors of aneurysm CD3+ T cell infiltration and / or CD68+ macrophage infiltration,

[0073] (iii) the application of inulin in the preparation of aneurysm macrophages to M1 pro-inflammatory phenotype polarization inhibitors and / or macrophages to M2 anti-inflammatory phenotype polarization accelerators, the preferred macrophages are aneurysms local macrophages,

[0074] (iv) the application of inulin in the preparation of an intestinal barrier-related protein gene expression promoter, the intestinal barrier-related protein at least including one of tight junction protein, occludin, mucin, and ca...

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PUM

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Abstract

The invention belongs to the technical field of researches on inulin, abdominal aortic aneurysm and small intestine diseases, and particularly discloses novel applications of inulin. The invention discloses a novel application of inulin in preparation of preparations for preventing and treating aortic aneurysm. The invention discloses an application of inulin in preparation of preparations for preventing and treating small intestine diseases. The invention relates to applications of inulin in preparation of preparations for preventing and treating small intestine barrier disorder diseases and / or small intestine barrier disorder induced diseases. The preparations for preventing and treating aortic aneurysm contain inulin. The preparations for preventing and treating small intestine diseases contain inulin. The preparations for preventing and treating small intestine barrier disorder induced diseases contain inulin. According to the invention, therapeutic regimens are provided for some symptoms in small intestine diseases, abdominal aortic aneurysm, etc., thereby providing better solutions for lesions caused by the pathogenic basic diseases, achieving treatment effect, overcoming some prejudice on applications of inulin, and developing new applications of inulin.

Description

technical field [0001] The invention belongs to the technical field of inulin research, and in particular relates to a new application of inulin. Background technique [0002] Inulin (chemical formula C 228 h 382 o 191 ) is contained in the protoplasm of cells in the form of colloid. Unlike starch, it is easily soluble in hot water and precipitates from water when ethanol is added, and does not react with iodine. Moreover, inulin is easily hydrolyzed to fructose under dilute acid, which is the characteristic of all fructans. It can also be hydrolyzed to fructose by inulase. Both humans and animals lack the enzymes that break down inulin. The inulin molecule is composed of about 31 β-D-fructofuranose and 1-2 inulin pyranoside residues, and the fructose residues can be connected by β-2,1-bonds. It is a linear linear polysaccharide linked by D-fructose through β(1→2) glycosidic bonds, often with a glucose residue at the end, and the degree of polymerization (DP) is 2 to 6...

Claims

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Application Information

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IPC IPC(8): A61K31/733A61P35/00A61P1/00A61P31/04A61P9/00A61P29/00
CPCA61K31/733A61P1/00Y02A50/30
Inventor 程翔郭爽杨芬张继宇查灵风廖雨涵何姝杰
Owner XIEHE HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI & TECH UNIV
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