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Anti-tumour traditional Chinese medicine composition, and preparation method and application thereof

A composition and anti-tumor technology, applied in anti-tumor drugs, drug combinations, pharmaceutical formulations, etc.

Active Publication Date: 2021-11-30
NANJING HIGH WIT BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no report on the application of Pulsatilla Decoction in diffuse large B-cell lymphoma

Method used

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  • Anti-tumour traditional Chinese medicine composition, and preparation method and application thereof
  • Anti-tumour traditional Chinese medicine composition, and preparation method and application thereof
  • Anti-tumour traditional Chinese medicine composition, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] The traditional Chinese medicine composition is composed of the following raw materials: 20 parts of Astragalus membranaceus, 12 parts of Smilax smilax, 15 parts of Pulsatilla chinensis, 12 parts of Cortex Phellodendri, 6 parts of Coptis chinensis and 12 parts of Qinpi.

[0046] Put the traditional Chinese medicine raw materials of the formula into the container, add 8 times the amount of water of the medicinal materials, soak for 0.5-10 hours, decoct and extract 3 times, the first time is 2 hours, the second time is 1 hour, the third time is 1 hour, and decoction After removing the dregs and extracting the juice, they are combined and concentrated to prepare an extract. Add distilled water to the extract of the raw materials prepared above, and filter to make a mixture or decoction.

Embodiment 2

[0048] The traditional Chinese medicine composition is composed of raw materials in the following proportions: 40 parts of astragalus, 24 parts of smilax, 30 parts of pulsatilla, 24 parts of cortex phellodendri, 12 parts of berberine, and 24 parts of bark.

[0049] Put the traditional Chinese medicine raw materials of the formula into a container, add 16 times the amount of water of the medicinal materials, soak for 0.5-10 hours, decoct and extract twice, the first time is 2 hours, the second time is 1 hour, decoct to remove residue and extract juice and combine Concentrated to prepare an extract. Add distilled water to the extract of the raw materials prepared above, and filter to make a mixture or decoction.

Embodiment 3

[0051] The traditional Chinese medicine composition is composed of raw materials in the following proportions: 60 parts of astragalus, 36 parts of smilax, 45 parts of pulsatilla, 36 parts of cortex phellodendri, 18 parts of berberine, and 36 parts of bark.

[0052] Add 70% ethanol with a volume 12 times the weight of the total medicinal materials, soak for 0.5-10 hours, continuously reflux extraction for 3 times, each time for 3 hours, combine the extracts, concentrate under reduced pressure at 80°C, and concentrate to prepare an extract. Add distilled water to the extract of the raw materials prepared above, and filter to make a mixture or decoction.

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Abstract

The invention relates to a traditional Chinese medicine composition, in particular to an anti-tumour traditional Chinese medicine composition and a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicine. The anti-tumour traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 20-60 parts of radix astragali, 12-36 parts of rhizoma smilacis glabrae, 15-45 parts of radix pulsatillae, 12-36 parts of cortex phellodendri, 6-18 parts of rhizoma coptidis and 12-36 parts of cortex fraxini. The traditional Chinese medicine composition disclosed by the invention is scientific and reasonable in compatibility, exact in pharmacological activity, good in safety and low in adverse reaction, has anti-tumour activity, and is applied to in-vivo and in-vitro anti-tumour activity of different types of tumours; and it is found that the composition has an obvious anti-tumour effect on human lymphoma cells, lung cancer cells, breast cancer cells, gastric cancer cells, cervical cancer cells, colon cancer cells, esophageal cancer cells, osteosarcoma cells, promyelocytic acute leukemia cells, ovarian cancer cells, multiple myeloma cells, neuroblastoma cells, liver cancer cells, malignant melanoma cells and the like.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition for tumors and its preparation method and application, belonging to the technical field of traditional Chinese medicine. Background technique [0002] Among malignant lymphomas, diffuse large B cell lymphoma (DLBCL) is the most common pathological type. Although rituximab has significantly improved the curative effect and prognosis of DLBCL, a large number of studies have shown that extranodal involvement is still a poor prognostic factor for lymphoma in the era of targeted therapy, and the prognosis of DLBCL primary in the central nervous system, testis, etc. worse. There is currently no uniform or standard treatment for DLBCL. The treatment methods mainly include combination therapy such as surgery, chemotherapy, monoclonal antibodies, and new targeted drugs. Surgery plays an important role in early diagnosis and treatme...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/90A61K36/896A61P35/00A61P35/02
CPCA61K36/481A61K36/90A61K36/896A61K36/71A61K36/756A61K36/718A61K36/63A61K36/344A61K36/488A61P35/00A61P35/02A61K2236/331A61K2236/39A61K2236/51A61K2236/333A61K2300/00
Inventor 赵玉娟倪海雯
Owner NANJING HIGH WIT BIOTECH
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