Extraction method of cannabidiol

A technology of cannabidiol and extraction method, which is applied in the field of extraction and purification of cannabidiol, can solve the problems of difficult removal of impurities, low product purity, complicated process, etc., and achieve low production cost, high product purity, inclusion and stable effect

Pending Publication Date: 2022-01-04
于立群
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to solve the problem that the existing extraction method needs to use organic solvents, is not environmentally friendly, consumes a lot of energy, is difficult to remove impurities, has low product purity, complex refining proce

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] (1) Dried hemp flowers and leaves are added to water at a mass ratio of 1:10. Raise the temperature to 50 degrees, stir for 1 hour, filter and separate, rinse the filter cake with water, and the liquid contains required CDBA (cannabidiolic acid) and other valuable cannabinol substances.

[0020] (2) Take beta-cyclodextrin (beta-cyclodextrin) or derivatives of beta-cyclodextrin, add water, prepare 10% aqueous solution, and heat to 60 degrees.

[0021] (3) While stirring, add the hemp extract into the beta-cyclodextrin solution, and beta-cyclodextrin and cannabidiolic acid begin to form inclusion complexes. The solubility of the inclusion complexes is very low and will precipitate from water Come out, stir for 1-2 hours, the precipitate is no longer increasing. The clathrate was isolated by filtration. The clathrate is analyzed by HPLC and does not contain THCA, that is: beta-cyclodextrin can selectively not absorb THCA, and THCA is a prerequisite for THC. The clathrat...

Embodiment 2

[0026] (1) The freshly harvested hemp flowers and leaves (without drying treatment) are added to water at a mass ratio of 1:5. Raise the temperature to 60 degrees, stir for 1 hour, filter and separate, rinse the filter cake with water, the liquid contains the required CDBA (cannabidiolic acid) and other valuable cannabinol substances.

[0027] (2) Take beta-cyclodextrin (beta-cyclodextrin) or derivatives of beta-cyclodextrin, add water, prepare 10% aqueous solution, and heat to 60 degrees.

[0028] (3) While stirring, add the hemp extract into the beta-cyclodextrin solution, and beta-cyclodextrin and cannabidiolic acid begin to form inclusion complexes. Precipitate out. After stirring for 1-2 hours, the precipitate did not increase any more. The clathrate was isolated by filtration. The clathrate is analyzed by HPLC and does not contain THCA, that is: beta-cyclodextrin can selectively not absorb THCA, and THCA is a prerequisite for THC. The clathrate can be sold directly o...

Embodiment 3

[0029] Example 3: Extraction of CDBA (cannabidiolic acid).

[0030] Take the clathrate of Example 2, add it to ethanol at a ratio of 1:5, stir for one hour, filter, and rinse the filter cake (beta-cyclodextrin) for recycling. After the filtrate was concentrated, it was frozen and crystallized. Get 95% CDBA (cannabidiolic acid).

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Abstract

An extraction and purification refining method of cannabidiol belongs to the technical field of cannabidiol extraction. The method specifically comprises the following steps of: adding China-hemp flowers and leaves into water, heating to 30-70 DEG C, stirring for 1 hour, filtering and separating to obtain filtrate containing CDBA and other valuable cannabinol substances; adding beta-cyclodextrin or a derivative thereof into water to prepare an aqueous solution, and heating to 60 DEG C; adding a China-hemp extracting solution into the aqueous solution of beta-cyclodextrin or the derivative thereof while stirring to form an inclusion compound from beta-cyclodextrin and cannabidiolic acid, precipitating the inclusion compound from water, stirring for 1-2 hours, filtering to separate out the inclusion compound, and carrying out vacuum heating at 90 DEG C for 1 hour, so as to convert CBDA into CBD cannabidiol. The method does not need an organic solvent, the product purity is high, the extraction and refining of CBDA and the removal of THC are completed in one step, the investment is small, and the production cost is low. The inclusion compound of the Beta-cyclodextrin and the CBDA is stable, good in water solubility and high in biological activity.

Description

technical field [0001] The invention belongs to the technical field of cannabidiol extraction, in particular to a method for extracting and purifying cannabidiol. Background technique [0002] Cannabis (cannabissatival.) is an annual herb of the Cannabis genus of the Cannabis family. The phenolic substances isolated from the cannabis plant mainly include thc (tetrahydrocannabinol, tetrahydrocannabinol), cbd (cannabidiol, cannabidiol), cbc (cannabichromene, cannabigerol), cbn (cannabinol, cannabidiol), cbg (cannabigerol, cannabigerol), etc., among which cbd has high medicinal value. British gw company has developed epidiolex (a liquid preparation containing cbd) for the treatment of epilepsy in children. [0003] In 1988, the United Nations clearly stipulated that industrial hemp with a THC content of <0.3% in the flower leaves of hemp during the growth period can be legally carried out in large-scale planting and industrialized development and utilization. The cbd in ind...

Claims

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Application Information

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IPC IPC(8): C07C37/68C07C37/86C07C37/84C07C39/23
CPCC07C37/685C07C37/86C07C37/84C07C2601/16C07C39/23
Inventor 于立群
Owner 于立群
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