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Suture-free blood coagulation auxiliary fixation heart patch and preparation method thereof

A heart and blood coagulation technology, applied in medical science, ligaments, prostheses, etc., can solve the problems of large trauma, weak patch fit, easy slipping, etc., to reduce postoperative complications, improve myocardial repair effect, The effect of reducing the difficulty of surgery

Active Publication Date: 2022-01-11
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Most of the implantation methods of existing cardiac patches are suture and bonding, and the suture method has problems such as complicated operation process, large trauma, easy postoperative complications and long recovery time (recorded in literature 1 (An Elastic, Biodegradable Cardiac Patch Induces Contractile Smooth Muscle and Improves CardiacRemodeling and Function in Subacute Myocardial Infarction[J].Journal of the American College of Cardiology,2007,49(23):2292-2300)), there is a problem that the patch is not firmly attached and is easy to slip Problem (recorded in literature 2 (Engineering a naturally-derived adhesive and conductive cardiopatch[J].Biomaterials,2019,207) and literature 3(Flexible shape-memory scaffold for minimally invasive delivery of functional tissues[J].Nature Materials,2017) )
Adding a microneedle array on the side of the patch facing the heart has been proven to assist in the fixation of the patch. The shape of the microneedles is mostly conical without barbs, and the base of the patch is mostly smooth (recorded in literature 4 Cardiaccell–integrated microneedle patch for treating myocardial infarction[J].Science Advances,2018,4(11)), when the base of this heart patch is working, there is still a gap between it and the myocardium, which cannot be fully fitted

Method used

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  • Suture-free blood coagulation auxiliary fixation heart patch and preparation method thereof
  • Suture-free blood coagulation auxiliary fixation heart patch and preparation method thereof
  • Suture-free blood coagulation auxiliary fixation heart patch and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0078] A method for preparing a suture-free coagulation-assisted fixation heart patch, comprising the steps of:

[0079] Raw material preparation:

[0080] Barbed microneedle: The diameter of the microneedle is 0.4mm, and the angle between the inclined surface of the inclined surface and the axial direction of the microneedle is 30°; the cross-sectional shape of the barb is triangular; along the longitudinal direction of the microneedle, 3 groups of barbs are distributed Each group of barbs consists of three barbs, and the angle between the barbs and the microneedles is 30°; the material of the barb microneedles is polylactic acid.

[0081] A universal mechanical testing machine (Instron 5543A) was used to measure the force when the barbed microneedle was inserted into the chicken breast and pulled out from the chicken breast to be 0.122N.

[0082] (1) By 3D printing model A, model A includes a base, and several cylinders and spherical recessed structures are formed on one si...

Embodiment 2

[0088] A method for preparing a suture-free coagulation-assisted fixation heart patch, comprising the steps of:

[0089] Raw material preparation:

[0090] Barbed microneedle: The diameter of the microneedle is 0.5mm, and the angle between the inclined surface of the inclined surface and the axial direction of the microneedle is 30°; the cross-sectional shape of the barb is triangular; 4 groups of barbs are distributed along the longitudinal direction of the microneedle Each group of barbs is composed of 3 barbs, and the angle between the barbs and the microneedles is 30°; the material of the barb microneedles is polycaprolactone.

[0091] A universal mechanical testing machine (Instron 5543A) was used to measure the force when the barbed microneedle was inserted into the chicken breast and pulled out from the chicken breast to be 0.200N.

[0092] Porogen: use a sieve to screen out gelatin microspheres with a diameter of 100 μm.

[0093] (1) By 3D printing the model C, the m...

Embodiment 3

[0099] A method for preparing a suture-free coagulation-assisted fixation heart patch, comprising the steps of:

[0100] Raw material preparation:

[0101] Barbed microneedle: The diameter of the microneedle is 0.4mm, and the angle between the inclined surface of the inclined surface and the axial direction of the microneedle is 30°; the cross-sectional shape of the barb is square; 5 groups of barbs are distributed along the longitudinal direction of the microneedle Each set of barbs consists of 3 barbs, and the angle between the barbs and the microneedles is 30°; the barbed microneedles are made of polypropylene.

[0102] A universal mechanical testing machine (Instron 5543A) was used to measure the force when the barbed microneedle was inserted into the chicken breast and pulled out from the chicken breast to be 0.220N.

[0103] (1) By 3D printing the model E, the model E includes a base, and several cylinders are formed on one side of the base, and the several cylinders ar...

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Abstract

The invention relates to a suture-free blood coagulation auxiliary fixation heart patch and a preparation method thereof. The heart patch comprises a polymer procoagulant substrate and barb microneedles fixed on the polymer procoagulant substrate, and microporous structures which do not penetrate through a polymer solid substrate are arranged on one side surface, with the microneedles, of the polymer procoagulant substrate. The barb microneedles are microneedles with barbs, the included angle alpha between the microneedles and the plane where the polymer procoagulant substrate is located ranges from 60 degrees to 90 degrees, the microneedles are evenly distributed on the polymer procoagulant substrate, and the distribution density is 5-50 / cm<2>. The barbs are located on the curved surfaces of the microneedles and face the polymer procoagulant substrate. According to the preparation method, a mold pore-forming method, a pore-forming agent pore-forming method or a thermally induced phase separation pore-forming method is adopted, the barb microneedles are combined while the microporous structures are formed, the suture-free blood coagulation auxiliary fixation heart patch is obtained, the method is simple, and the prepared heart patch is excellent in treatment effect.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and relates to a suture-free coagulation-assisted fixation heart patch and a preparation method thereof. Background technique [0002] Myocardial infarction is a relatively common and fatal type of cardiovascular disease, the main cause of which is myocardial necrosis caused by myocardial hypoxia-ischemia. Compared with traditional drugs, cell therapy and other methods, heart patch can provide mechanical support for infarcted myocardium, inhibit left ventricular remodeling, slow down heart failure, and maintain heart function. Combined with drug therapy. [0003] Most of the implantation methods of existing cardiac patches are suture and bonding, and the suture method has problems such as complicated operation process, large trauma, easy postoperative complications and long recovery time (recorded in literature 1 (An Elastic, Biodegradable Cardiac Patch Induces Contractile Smooth M...

Claims

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Application Information

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IPC IPC(8): A61F2/08A61F2/00
CPCA61F2/0063A61F2/08A61F2/0811A61F2002/0847A61F2002/0817
Inventor 朱旸鲁育文高长有任探琛沈励胤洪晓倩
Owner ZHEJIANG UNIV
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