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Preparation method of dry dendrobium alcohol extract for spontaneous hypertension

A technology of dendrobium alcohol and high blood pressure, which is applied in the field of preparation of dry dendrobium ethanol extract for spontaneous hypertension, can solve the problems of cumbersome preparation and untested curative effect of dendrobium, and achieve the promotion of metabolic degradation, atherosclerosis and hypertension , good effect

Inactive Publication Date: 2022-01-21
安徽同济生生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The compound Dendrobium officinale enzyme in the above-mentioned patent has the following disadvantages: the preparation is cumbersome, although it has metabolic ability, the curative effect of Dendrobium candidum on diseases such as hypertension has not been tested

Method used

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  • Preparation method of dry dendrobium alcohol extract for spontaneous hypertension
  • Preparation method of dry dendrobium alcohol extract for spontaneous hypertension
  • Preparation method of dry dendrobium alcohol extract for spontaneous hypertension

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] A kind of preparation method of dry dendrobium ethanol extract for spontaneous hypertension, such as figure 1 shown, including the following steps:

[0040] S1: Wash the fresh dendrobium strips and dry them in a drying box until the moisture content is ≤8%;

[0041] S2: crush the obtained dried dendrobium and pass through a 70-mesh separation sieve to obtain dried dendrobium powder for subsequent use;

[0042] S3: Weigh 20g of dried dendrobium powder, place it in 450ml extract solution at 55°C and repeat the extraction three times, each extraction for 24 hours;

[0043] S4: after the two extracts are combined, the filter membrane is used to filter and sterilize to obtain a clarified liquid;

[0044] S5: obtained by concentrating the clarified liquid under reduced pressure to 1 / 6-1 / 8 of the original volume, and freeze-drying to constant weight.

[0045] The fresh Dendrobium is one or a combination of two or more of Dendrobium Huoshanense, Dendrobium candidum, Dendrobi...

Embodiment 2

[0049] A kind of preparation method of dry dendrobium ethanol extract for spontaneous hypertension, such as figure 1 shown, including the following steps:

[0050] S1: Wash the fresh dendrobium strips and dry them in a drying oven until the moisture content is ≤8%;

[0051] S2: crushing the obtained dried dendrobium and passing through an 80-mesh separation sieve to obtain dried dendrobium powder for subsequent use;

[0052] S3: Weigh 20g of dried dendrobium powder, place it in 350ml extract solution at 55°C and repeat the extraction twice, each time for 20 hours;

[0053] S4: after the two extracts are combined, the filter membrane is used to filter and sterilize to obtain a clarified liquid;

[0054] S5: obtained by concentrating the clarified liquid under reduced pressure to 1 / 6-1 / 8 of the original volume, and freeze-drying to constant weight.

[0055]The dry ethanol extract of Dendrobium is a preparation in granules, pills, capsules, tablets, powders, ointments or oral ...

Embodiment 3

[0057] A kind of preparation method of dry dendrobium ethanol extract for spontaneous hypertension, such as figure 1 shown, including the following steps:

[0058] S1: Wash the fresh dendrobium strips and dry them in a drying box until the moisture content is ≤8%;

[0059] S2: crush the obtained dried dendrobium and pass through a 90-mesh separation sieve to obtain dried dendrobium powder for subsequent use;

[0060] S3: Weigh 20g of dried dendrobium powder, place it in 400ml extract solution at 60°C and repeat the extraction twice, each time for 22 hours;

[0061] S4: after the two extracts are combined, the filter membrane is used to filter and sterilize to obtain a clarified liquid;

[0062] S5: obtained by concentrating the clarified liquid under reduced pressure to 1 / 6-1 / 8 of the original volume, and freeze-drying to constant weight.

[0063] The original preparation concentration of the dry Dendrobium ethanol extract is 100mg / ml.

[0064] The pore size of the filter ...

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Abstract

The invention discloses a preparation method of a dry dendrobium alcohol extract for spontaneous hypertension, and relates to the technical field of pharmacy. The problem of tedious preparation is solved. The preparation method specifically comprises the following steps that fresh dendrobium strips are cleaned and dried in a drying box until the water content is less than or equal to 8%; obtained dry dendrobium is crushed and sieved with a 60-100-mesh separation sieve to obtain dry dendrobium powder for later use; 20 g of the dry dendrobium powder is weighed and placed in 350-500 ml of an extracting solution at the temperature of 55-60 DEG C to be repeatedly extracted twice, and extraction lasts for 15-24 h each time is achieved; the two extracts are combined, and filtering and sterilizing are achieved by using a filter membrane to obtain a clear solution; and the clear solution is concentrated under reduced pressure until the volume is 1 / 6-1 / 8 of the original volume, and freeze-drying is achieved until the weight is constant. The fresh dendrobium is one or a combination of more than two of dendrobium huoshanense, dendrobium officinale, dendrobium nobile, dendrobium nobile, dendrobium fimbriatum and dendrobium chrysotoxum. According to the preparation method of the dry dendrobium alcohol extract for the spontaneous hypertension, the preparation method of the dry dendrobium alcohol extract for the spontaneous hypertension can inhibit atherosclerosis and assist in treating hypertension diseases.

Description

technical field [0001] The invention relates to the technical field of pharmacy, in particular to a preparation method of dry dendrobium ethanol extract for spontaneous hypertension. Background technique [0002] The etiology of hypertension is affected by factors such as heredity, spirit and environment, living habits, age, drugs and other diseases. Elevated cholesterol in hypertensive patients will lead to atherosclerosis, decreased blood vessel elasticity, and increased resistance of arterial blood in the process of arterial blood flow, which will increase the patient's blood pressure, which will promote the formation of atherosclerosis and aggravate the patient's condition , This relationship between high blood pressure and cholesterol forms a vicious circle, making it easier for high blood pressure complications to occur. Therefore, high blood pressure plus atherosclerosis must be treated comprehensively and early. Many existing drugs for the treatment of hypertension ...

Claims

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Application Information

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IPC IPC(8): A61K36/8984A61P9/12A61P9/10A61P3/06
CPCA61K36/8984A61P9/12A61P9/10A61P3/06A61K2236/333A61K2236/39A61K2236/51A61K2236/53
Inventor 余茂耘韩际宏段亚君梁英权杨潇潇陈元利张丰陈贵兰
Owner 安徽同济生生物科技有限公司
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