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Lipoprotein subtyping detection method and system

A detection method and technology for lipoprotein, which are applied in measurement devices, analysis materials, material analysis by electromagnetic means, etc., can solve the problems of inability to obtain lipoprotein content, and achieve the effect of simple structure and easy realization.

Pending Publication Date: 2022-01-21
上海淘源生物科技有限公司 +2
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Problems solved by technology

The problem with this detection method is that it is impossible to obtain the specific content of each subtype of lipoprotein

Method used

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  • Lipoprotein subtyping detection method and system
  • Lipoprotein subtyping detection method and system
  • Lipoprotein subtyping detection method and system

Examples

Experimental program
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Embodiment 1

[0050] Based on the above-mentioned lipoprotein subtyping detection system, the lipoprotein subtyping detection is performed, and the steps are as follows:

[0051] adding the lipoproteins in the serum or plasma to the gel column after staining;

[0052] Under the action of the electric field in the electrophoresis tank, relying on the molecular sieve effect of the gel, the subtypes of lipoproteins are separated in sequence according to the particle size;

[0053] Step 1: Scan the lipoprotein electrophoresis bands obtained based on gel electrophoresis to obtain such figure 2 Densitometric spectra shown;

[0054] Step 2: Preprocessing the optical density spectrum to obtain a calibration image;

[0055] Specifically, the step 2 includes:

[0056] Step 21: Obtain the contour area of ​​the test tube image in the scanned image, and split the scanned image into images to be cropped corresponding to a single test tube based on the contour area of ​​the test tube image;

[0057]S...

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Abstract

The invention discloses a lipoprotein subtyping detection system and method. The system comprises a scanning module, a calibration module, a processing module and an export module; the scanning module is used for scanning a lipoprotein optical density map obtained based on a gel electrophoresis method to obtain a scanning image; the calibration module is used for preprocessing the scanning image to obtain a calibration image; the processing module is used for calculating the cholesterol value of each lipoprotein subtype based on the calibration image; and the export module is used for exporting a processing result obtained by the processing module. According to the invention, accurate detection of cholesterol content of each subtype of lipoprotein can be realized.

Description

technical field [0001] The invention relates to the technical field of biological detection, in particular to a lipoprotein subtype detection method and a lipoprotein subtype detection system. Background technique [0002] Elevated low-density lipoprotein (LDL) cholesterol is one of the main risk factors for coronary heart disease. LDL can be divided into up to seven subtypes, from the largest to the smallest, designated LDL-1 to LDL-7, respectively. The LDL-1 and LDL-2 subtypes, which have larger particle sizes, are assigned type A, while the smaller particle-sized LDL-3 to LDL-7 subtypes are assigned type B. At the same time, according to particle diameter and density, it is divided into large and light LDL (largebuoyant LDL, lbLDL) and small and dense LDL (small dense LDL, sdLDL). The detection of lipoprotein in the prior art mainly detects the content of lipoprotein by enzymatic method. The problem with this detection method is that it is impossible to obtain the spec...

Claims

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Application Information

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IPC IPC(8): G01N27/447
CPCG01N27/44721
Inventor 佘鹏牛钦张媛媛
Owner 上海淘源生物科技有限公司
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