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Antiviral pharmaceutical composition, method for inhibiting in-vitro virus activity and application of antiviral pharmaceutical composition

An antiviral drug and composition technology, applied in the field of medicine, can solve problems such as ineffectiveness or slight curative effect, and achieve the effects of improving cytopathic conditions, inhibiting virus replication, and having a good dose-effect relationship.

Active Publication Date: 2022-01-28
TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because viruses are strictly parasitic and resistant to antibiotics, antibiotic-based treatments for viral infections are generally ineffective or have little effect

Method used

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  • Antiviral pharmaceutical composition, method for inhibiting in-vitro virus activity and application of antiviral pharmaceutical composition
  • Antiviral pharmaceutical composition, method for inhibiting in-vitro virus activity and application of antiviral pharmaceutical composition
  • Antiviral pharmaceutical composition, method for inhibiting in-vitro virus activity and application of antiviral pharmaceutical composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] This example is an in vitro anti-respiratory and enterovirus pharmacodynamic study of perilla leaf alcohol extract. According to the pathogenic characteristics of each virus strain and the characteristics of traditional Chinese medicine, based on the in vitro cell virus infection model, the corresponding in vitro antiviral efficacy is designed. science test. Four doses of 100, 10, 1, and 0.1 mg / mL of perilla leaf alcohol extract were designed to observe its effects on 11 kinds of respiratory viruses and 6 kinds of enteroviruses causing cytopathic effects (CPE), cell survival rate, and inhibition of virus replication. Evaluation of its antiviral efficacy is as follows:

[0055] 1. Extraction

[0056] Weigh an appropriate amount of perilla leaves, mix the perilla leaves with 70% ethanol aqueous solution at a volume concentration of 1g:8mL, heat and reflux for extraction for 2 hours, extract twice, filter, combine the filtrates, concentrate into an extract, vacuum Dried ...

Embodiment 2

[0166] This example is an experimental study on the in vitro anti-respiratory and enterovirus pharmacodynamics of perilla leaf water extract. According to the pathogenic characteristics of each virus strain and the characteristics of traditional Chinese medicine, based on the in vitro cell virus infection model, the corresponding in vitro antiviral efficacy is designed. science test. Four doses of 100, 10, 1, and 0.1 mg / mL of perilla leaf water extract were designed to observe its effect on 11 kinds of respiratory viruses and 6 kinds of enteroviruses causing cytopathic (CPE), cell survival rate, and evaluate its antiviral drugs effect. details as follows:

[0167] 1. Extraction

[0168] Weigh an appropriate amount of perilla leaves, mix perilla leaves with water according to the ratio of 1g perilla leaves: 10mL water, heat and reflux for decoction, extract for 2 hours, extract twice, filter, combine filtrates, concentrate into extract, vacuum Dried to obtain perilla leaf wa...

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Abstract

The invention discloses an antiviral pharmaceutical composition, a method for inhibiting in-vitro virus activity and application of the antiviral pharmaceutical composition. The pharmaceutical composition comprises a perilla leaf extract. The perilla leaf extract shows low cytotoxicity, has an obvious inhibition effect on respiratory viruses (including influenza A viruses and human coronaviruses) and enteroviruses under the condition of no cytotoxicity concentration, and can improve the cytopathy condition, increase the survival rate of virus infected host cells, effectively inhibit virus replication, meanwhile, a relatively good dose-effect relationship is shown, and an obvious antiviral effect is achieved.

Description

technical field [0001] The invention relates to the field of medicine, in particular to an antiviral drug composition and a method and application for inhibiting virus activity in vitro. Background technique [0002] Viruses that cause viral diseases, such as influenza, respiratory viral infections, enteroviral infections, etc., not only cause periodic pandemics around the world, but some viruses can also cause clinical acute onset with high fever, disturbance of consciousness, convulsions , tonic spasm and meningeal irritation and other diseases, severe cases often have sequelae. Because viruses are strictly parasitic and resistant to antibiotics, antibiotic-based treatment of viral infections is generally ineffective or has little effect. Traditional Chinese medicine has experienced thousands of years of development in China, and it has an irreplaceable role in anti-virus. [0003] Because traditional Chinese medicine adopts individualized treatment, it is more targeted ...

Claims

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Application Information

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IPC IPC(8): A61K36/535A61P31/16A61P31/14A61K127/00
CPCA61K36/535A61P31/16A61P31/14A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61K2236/333Y02A50/30
Inventor 高秀梅姚荣妹吕彬王涛何俊韩立峰郭金赫杜耀东邱峰刘志东
Owner TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE
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