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Active monitoring and early warning system for drug-induced diseases

A technology for monitoring, early warning, and disease, applied in the medical field, can solve problems such as missed opportunities for ADE intervention, false positives in the ADE/ME monitoring system, poor timeliness of samples, etc., to achieve the effect of ensuring accuracy and strengthening risk management and control of clinical medication

Active Publication Date: 2022-02-01
SICHUAN ACADEMY OF MEDICAL SCI SICHUAN PROVINCIAL PEOPLES HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] 1. The current ADE / ME monitoring system has problems such as false positives, missed negatives, low reporting rate, low reporting accuracy, and inconsistent evaluation standards for the correlation between suspicious drugs and adverse events, so it cannot reflect the true occurrence level of ADE or ME. This further resulted in the small sample size, low sample quality and poor timeliness of the raw data of adverse drug event research, which brought inconvenience to clinical drug safety supervision and drug quality feedback
[0005] 2. Some ADE / ME can be avoided or discovered at an early stage, but the current ADE / ME monitoring system is mostly for post-event treatment and lacks an early warning mechanism. The lack of early warning makes clinical treatment miss the best time to intervene in ADE, increasing the Incidence and severity of ADEs
[0006] 3. ADE reporting requires accuracy and needs a certain amount of time to be evidence-based, while ADE early warning requires timeliness and early warning of potential ADE risks. The current ADE / ME monitoring system is difficult to simultaneously meet the requirements of accurate reporting and timely early warning

Method used

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  • Active monitoring and early warning system for drug-induced diseases

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0129] Example 1: For patients over 65 years old with a history of falls or fractures, the drugs on the high-risk drug list include: midazolam, diazepam, alprazolam, diazepam, nitrazepam, and clonazepam , lorazepam, sulpiride, flupenthixol, melitracen, risperidone, clozapine, droperidol.

[0130] Drugs in the list of contraindicated drugs include: sulpiride, flupenthixol, melitracen, risperidone, clozapine, droperidol. The above list can be sent to the patient's physician in charge to remind the risks of medication.

example 2

[0131] Example 2: When the patient in Example 1 has new symptoms of heart failure, the newly added drugs in the prohibited drug list for the patient should include: cilostazol and non-steroidal anti-inflammatory drugs.

[0132] Compared with the prior art, the beneficial effect of the present invention is that the patient medication risk prompt module can output the latest prohibited drug list and high-risk medication list based on the patient's real-time physical condition, and send them to the competent physician and pharmacist in the form of a list of precautions for medication. Clinical medication provides accurate and timely reference, forming the first level of risk prevention and control beforehand.

[0133] The patient medication risk assessment module comprehensively evaluates the possibility of adverse drug events occurring in the patient according to the patient's physical condition and medication situation.

[0134] Preferably, the patient medication risk assessmen...

example 3

[0151] Example 3: Adverse events in the adverse event set of ibuprofen include: liver injury, parameters of adverse events related to liver injury include: (1) ALT>40U / L (upper limit of normal value), TB>1×ULN ( Upper limit of normal value), (2) ALT>2×ULN (2 times upper limit of normal value) in a single test, TB>2×ULN (upper limit of normal value). The ADE / ME intervention parameters of ibuprofen-induced liver injury include: (1) discontinuation or reduction of ibuprofen, (2) glutathione, tiopronin, glycyrrhizic acid preparations, polyene phosphorylcholine apply.

[0152] The medication process monitoring and early warning module includes: (1) a graded early warning sub-module, which is used to output different levels of monitoring of suspected adverse drug events, upcoming medication errors, and medication errors that have occurred according to risk levels. early warning. (2) Risk degree monitoring and early warning sub-module, which is used to: monitor the patient treatmen...

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Abstract

The invention relates to an active monitoring and early warning system for drug-induced diseases, which is used for monitoring clinical treatment process information of a patient, carrying out graded early warning on adverse drug events and drug use errors and actively reporting. After the medication risk information is monitored, graded early warning is output, and the early warning grade is comprehensively obtained by the medication risk assessment result of the patient and the danger degree of the monitored medication risk information; meanwhile, based on the treatment process information of the patient, after the relevance between the adverse reaction and the suspicious medicine is determined, the adverse event of the medicine is actively reported, the medicine use risk is effectively prevented, and the reporting rate and reporting accuracy of the adverse event are improved.

Description

technical field [0001] The invention relates to the field of medical technology, in particular to an active monitoring and early warning system for drug-induced diseases. Background technique [0002] Adverse drug events (ADEs) and medication errors (ME) are one of the main causes of drug-induced diseases. Important measures of institutional adverse event rates. The current main ADE monitoring methods include adverse event medical record review method and voluntary reporting system method. The occurrence of ADE is collected through medical record review and voluntary reporting. The number and quality of reports and signal detection capabilities of this method depend on medical institutions. Reporting awareness and cooperation, there are problems such as false positives, missed negatives, and post-event reporting, which cannot reflect the true occurrence level of ADE or ME, and the current ADE monitoring is "post-event" passive monitoring, lacking in advance prevention. [...

Claims

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Application Information

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IPC IPC(8): G16H10/60G16H70/40G08B21/18G08B21/24
CPCG16H10/60G16H70/40G08B21/182G08B21/24
Inventor 边原郑星月雷洋尹琪楠罗尧韩丽珠李炼童荣生杨勇龙恩武闫峻峰吴丽吴行伟何林舒永全
Owner SICHUAN ACADEMY OF MEDICAL SCI SICHUAN PROVINCIAL PEOPLES HOSPITAL
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