Preparation method and detection method of sculellaria barbata formula granules
A technology for formula granules and bark lotus, which is applied in the preparation of test samples, pharmaceutical formulations, medical preparations with non-active ingredients, etc., can solve the problems of many factors, non-compliance with requirements, and low cost of active ingredient content differences. , to achieve maximum utilization, controllable process steps, and high drug yield.
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preparation example Construction
[0076] A1-1. Preparation of reference substance solution Take an appropriate amount of scutellarin reference substance, weigh it accurately, add methanol to make a solution containing 0.2 mg per 1 mL, and obtain scutellarin reference substance solution A;
[0077] B1-1. Preparation of standard curve Precisely measure 0.4mL, 0.8mL, 1.2mL, 1.6mL, 2.0mL of the scutellarin reference solution A, put them in 25mL measuring bottles, add methanol to the mark, shake well, and add methanol As a blank, measure the absorbance at a wavelength of 335nm according to UV-Vis spectrophotometry, take the absorbance as the ordinate, and the concentration as the abscissa, draw a standard curve, the standard curve is as follows figure 1 shown;
[0078] C1-1. Determination method Take 1g of Scutellaria barbata raw material, accurately weigh it, put it in a Soxhlet extractor, add petroleum ether at 60~90°C to extract until it is colorless, discard the ether solution, evaporate the petroleum ether fr...
Embodiment 1
[0093] A preparation method of Scutellaria barbata formula granules, comprising the following steps:
[0094] A. Select the raw material of Scutellaria barbata, control the content of total flavonoids in the raw material of Scutellaria barbata to be 1.99%, and the content of scutellarin to be 0.36%;
[0095] B. Put the raw materials into the dry cleaning machine to remove the silt and medicine chips, adjust the motor frequency of the dry cleaning machine to 30HZ / min, and adjust the motor frequency of the fan to 15HZ / min; put the dry-cleaned Scutellaria barbata into the cutting machine, Obtain 1cm barbatae decoction pieces;
[0096] C. Put the decoction pieces of Banzhilian into the extraction tank, add 12 times the amount of water, decoct and extract for 0.5h at a temperature of 94°C, use 40 mesh, 80 mesh, and 200 mesh screens to perform three-stage filtration, extract the liquid medicine, and discharge Medicinal dregs; then add 10 times the amount of water to the medicinal d...
Embodiment 2
[0102] A preparation method of Scutellaria barbata formula granules, comprising the following steps:
[0103] A. Select the raw material of Scutellaria barbata, control the content of total flavonoids in the raw material of Scutellaria barbata to be 3.32%, and the content of scutellarin to be 0.52%;
[0104] B. Put the raw materials into the dry cleaning machine to remove the sediment and medicine shavings, adjust the motor frequency of the dry cleaning machine to 37HZ / min, and adjust the motor frequency of the fan to 25HZ / min; put the dry-cleaned Scutellaria barbata into the cutting machine, Obtain 2cm Scutellaria barbata pieces;
[0105] C. Put the decoction pieces of Scutellaria barbata into the extraction tank, add 13 times the amount of water, decoct and extract for 1 hour at a temperature of 98°C, use 40-mesh, 80-mesh, and 200-mesh screens to perform three-stage filtration, extract the liquid medicine, and discharge the medicine Dregs; then add 12 times the amount of wa...
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