Preparation method and detection method of sculellaria barbata formula granules

A technology for formula granules and bark lotus, which is applied in the preparation of test samples, pharmaceutical formulations, medical preparations with non-active ingredients, etc., can solve the problems of many factors, non-compliance with requirements, and low cost of active ingredient content differences. , to achieve maximum utilization, controllable process steps, and high drug yield.

Pending Publication Date: 2022-02-11
SICHUAN NEO GREEN PHARMA TECH DEV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] 3. The demand for traditional Chinese medicine formula granules is increasing, and there are many factors that lead to the difference in the content of active ingredients. How to determine the production process to make it low-cost and suitable for large-scale production is also a problem faced by various manufacturers;
[0013] 5. The traditional Chinese medicine brewing has certain requirements on temperature, heat, cooking time and water add

Method used

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  • Preparation method and detection method of sculellaria barbata formula granules
  • Preparation method and detection method of sculellaria barbata formula granules

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0076] A1-1. Preparation of the solution solution to extract a wild baicide control, precisely, and add methanol to obtain a solution containing 0.2 mg of solution to obtain a porrobinicin-free substance A;

[0077] B1-1. Preparation of standard curve A0.4ml, 0.8 mL, 1.2 mL, 1.6 mL, 2.0mL, 1.2ml, 1.6 ml, 2.0ml of 25 mL, plus methanol, shake, methanol, and mixed It is blank, and the absorbance is measured at a wavelength of 335 nm, and the absorbance is equal to the wavelength of 335 nm. The standard curve, the standard curve, such as the absorbance. figure 1 Indicated;

[0078] C1-1. Determination of half-branched lotus raw materials 1g, precision weighing, in the seipher extractor, plus 60 ~ 90 ° C oil ether extract to colorless, discard the ether solution, and the petroleum ether, plus Methanol continues to extract until colorless, transferred to 100 mL of volumetric flask, add methanol to the scale, shake, precipitated quantum, dry, residue is dissolved with 20% methanol, trans...

Example Embodiment

[0092] Example 1

[0093] Preparation method of a half-branching formula granule, including the following steps:

[0094] A. Select a half lotus raw material to control the total flavonoid content in the raw material of the half lotus. The content of wild baicine is 0.36%;

[0095] B, put the raw material into the dry cleaning machine, remove the sediment and the drug, the motor frequency of the dry cleaner is adjusted to 30Hz / min, the motor frequency of the fan is adjusted to 15 hz / min; put the dried semi-lotus to cut the integrated machine. Get 1 cm half-branch losses;

[0096] C. Half lotus dosage is added to the extraction tank, add 12 times the amount of water, decoction extract 0.5 h, temperature is 94 ° C, with 40 mesh, 80 mesh, 200 mesh screen, extract the liquid, discharge Phaffinity; then add 10 times water, decoction extract 0.4 h, temperature is 94 ° C, so extract 2 times, after extracting the dispersion, the liquid, to obtain a semi-volume extract The total flavon...

Example Embodiment

[0101] Example 2

[0102] Preparation method of a half-branching formula granule, including the following steps:

[0103] A. Select a half lotus raw material to control the total flavonoid content of 3.32% in the raw material of the half lotus. The poronine content is 0.52%;

[0104] B, put the raw material into the dry cleaner, remove the sediment and the drug, the motor frequency of the dry cleaner is adjusted to 37 Hz / min, the motor frequency of the fan is adjusted to 25 Hz / min; put the dried semi-lacel lotion to cut the one machine, Get 2cm half lotus drank;

[0105] C, half-branch dosage film is added to the extraction tank, add 13 times the amount of water, decoction extraction for 1 h, temperature is 98 ° C, with 40 mesh, 80 mesh, 200 mesh screen, extract the liquid, discharge the drug Slag; then add 12 times water, decoction extraction 1 h, temperature is 98 ° C, so extract 2 times, after the dispersion is extruded, the liquid is mixed, and the liquid solution is obtai...

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Abstract

The invention discloses a preparation method and a detection method of sculellaria barbata formula granules, and the preparation method comprises the following steps: selecting a sculellaria barbata raw material, and controlling the content of total flavonoids in the sculellaria barbata raw material to be 1.99%-4.41% and the content of scutellarin to be 0.36%-0.99%; performing dry cleaning and cutting treatment on a sculellaria barbata raw material to obtain sculellaria barbata decoction adding the sculellaria barbata decoction pieces into an extraction tank, adding water, decocting for the first time, filtering with a screen, extracting liquid medicine, and discharging dregs; adding water into the medicine residues, decocting for the second time, extruding the medicine residues to recover medicine liquid, and combining the medicine liquid to obtain a sculellaria barbata extracting solution; concentrating the sculellaria barbata extract under reduced pressure to obtain clear paste; dissolving the clear paste in pharmaceutic adjuvants, and performing spray drying to obtain dry extract powder; and adding pharmaceutical excipients into the dry extract powder, and carrying out dry granulation to obtain the sculellaria barbata formula granules. The invention can ensure that the obtained formula granules can be converted into traditional Chinese medicine decoction pieces with the same equivalent weight to meet prescription requirements.

Description

technical field [0001] The invention belongs to the technical field of Chinese patent medicine production, and in particular relates to a preparation method and a detection method of Scutellaria barbata formula granules. Background technique [0002] Scutellaria barbata, the name of traditional Chinese medicine. Scutellaria barbata Scute Laria barbata D.Don's dried whole herb. Have heat-clearing and toxic substances removing, blood stasis dispelling diuresis. For furuncle swelling, sore throat, tumbling pain, edema, jaundice, snake and insect bites. Decoction, 15-30g. It mainly contains alkaloids, flavonoid glycosides, saponins, amino acids, polysaccharides, inulin, safflower, isosafflorin, scutellarin, alpine scutellarein, barbatrin, barbata seed, p-coumaric acid, Protocatechuic acid and other ingredients. [0003] For the preparation of traditional Chinese medicine formula granules from raw medicinal materials of Scutellaria barbata, many technical problems are face...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K47/26A61K47/36A61K36/539G01N21/31G01N1/38
CPCA61K9/1652A61K9/1623A61K36/539G01N21/3103G01N1/38
Inventor 周厚成代德蓉吴琦吴琴张玉婷胡昌江周维
Owner SICHUAN NEO GREEN PHARMA TECH DEV
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