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Preparation method and detection method of sculellaria barbata formula granules

A technology for formula granules and bark lotus, which is applied in the preparation of test samples, pharmaceutical formulations, medical preparations with non-active ingredients, etc., can solve the problems of many factors, non-compliance with requirements, and low cost of active ingredient content differences. , to achieve maximum utilization, controllable process steps, and high drug yield.

Pending Publication Date: 2022-02-11
SICHUAN NEO GREEN PHARMA TECH DEV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] 3. The demand for traditional Chinese medicine formula granules is increasing, and there are many factors that lead to the difference in the content of active ingredients. How to determine the production process to make it low-cost and suitable for large-scale production is also a problem faced by various manufacturers;
[0013] 5. The traditional Chinese medicine brewing has certain requirements on temperature, heat, cooking time and water addition. It is difficult for different decocting personnel to control the various conditions, and the content of active ingredients in the obtained decoction is also very different. , not even meeting the requirements, ultimately falling short of prescription requirements
When the prepared granules are used in a medicine dispensing machine, there are still technical difficulties such as how to prevent the granules from absorbing moisture and sticking

Method used

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  • Preparation method and detection method of sculellaria barbata formula granules
  • Preparation method and detection method of sculellaria barbata formula granules

Examples

Experimental program
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Effect test

preparation example Construction

[0076] A1-1. Preparation of reference substance solution Take an appropriate amount of scutellarin reference substance, weigh it accurately, add methanol to make a solution containing 0.2 mg per 1 mL, and obtain scutellarin reference substance solution A;

[0077] B1-1. Preparation of standard curve Precisely measure 0.4mL, 0.8mL, 1.2mL, 1.6mL, 2.0mL of the scutellarin reference solution A, put them in 25mL measuring bottles, add methanol to the mark, shake well, and add methanol As a blank, measure the absorbance at a wavelength of 335nm according to UV-Vis spectrophotometry, take the absorbance as the ordinate, and the concentration as the abscissa, draw a standard curve, the standard curve is as follows figure 1 shown;

[0078] C1-1. Determination method Take 1g of Scutellaria barbata raw material, accurately weigh it, put it in a Soxhlet extractor, add petroleum ether at 60~90°C to extract until it is colorless, discard the ether solution, evaporate the petroleum ether fr...

Embodiment 1

[0093] A preparation method of Scutellaria barbata formula granules, comprising the following steps:

[0094] A. Select the raw material of Scutellaria barbata, control the content of total flavonoids in the raw material of Scutellaria barbata to be 1.99%, and the content of scutellarin to be 0.36%;

[0095] B. Put the raw materials into the dry cleaning machine to remove the silt and medicine chips, adjust the motor frequency of the dry cleaning machine to 30HZ / min, and adjust the motor frequency of the fan to 15HZ / min; put the dry-cleaned Scutellaria barbata into the cutting machine, Obtain 1cm barbatae decoction pieces;

[0096] C. Put the decoction pieces of Banzhilian into the extraction tank, add 12 times the amount of water, decoct and extract for 0.5h at a temperature of 94°C, use 40 mesh, 80 mesh, and 200 mesh screens to perform three-stage filtration, extract the liquid medicine, and discharge Medicinal dregs; then add 10 times the amount of water to the medicinal d...

Embodiment 2

[0102] A preparation method of Scutellaria barbata formula granules, comprising the following steps:

[0103] A. Select the raw material of Scutellaria barbata, control the content of total flavonoids in the raw material of Scutellaria barbata to be 3.32%, and the content of scutellarin to be 0.52%;

[0104] B. Put the raw materials into the dry cleaning machine to remove the sediment and medicine shavings, adjust the motor frequency of the dry cleaning machine to 37HZ / min, and adjust the motor frequency of the fan to 25HZ / min; put the dry-cleaned Scutellaria barbata into the cutting machine, Obtain 2cm Scutellaria barbata pieces;

[0105] C. Put the decoction pieces of Scutellaria barbata into the extraction tank, add 13 times the amount of water, decoct and extract for 1 hour at a temperature of 98°C, use 40-mesh, 80-mesh, and 200-mesh screens to perform three-stage filtration, extract the liquid medicine, and discharge the medicine Dregs; then add 12 times the amount of wa...

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Abstract

The invention discloses a preparation method and a detection method of sculellaria barbata formula granules, and the preparation method comprises the following steps: selecting a sculellaria barbata raw material, and controlling the content of total flavonoids in the sculellaria barbata raw material to be 1.99%-4.41% and the content of scutellarin to be 0.36%-0.99%; performing dry cleaning and cutting treatment on a sculellaria barbata raw material to obtain sculellaria barbata decoction adding the sculellaria barbata decoction pieces into an extraction tank, adding water, decocting for the first time, filtering with a screen, extracting liquid medicine, and discharging dregs; adding water into the medicine residues, decocting for the second time, extruding the medicine residues to recover medicine liquid, and combining the medicine liquid to obtain a sculellaria barbata extracting solution; concentrating the sculellaria barbata extract under reduced pressure to obtain clear paste; dissolving the clear paste in pharmaceutic adjuvants, and performing spray drying to obtain dry extract powder; and adding pharmaceutical excipients into the dry extract powder, and carrying out dry granulation to obtain the sculellaria barbata formula granules. The invention can ensure that the obtained formula granules can be converted into traditional Chinese medicine decoction pieces with the same equivalent weight to meet prescription requirements.

Description

technical field [0001] The invention belongs to the technical field of Chinese patent medicine production, and in particular relates to a preparation method and a detection method of Scutellaria barbata formula granules. Background technique [0002] Scutellaria barbata, the name of traditional Chinese medicine. Scutellaria barbata Scute Laria barbata D.Don's dried whole herb. Have heat-clearing and toxic substances removing, blood stasis dispelling diuresis. For furuncle swelling, sore throat, tumbling pain, edema, jaundice, snake and insect bites. Decoction, 15-30g. It mainly contains alkaloids, flavonoid glycosides, saponins, amino acids, polysaccharides, inulin, safflower, isosafflorin, scutellarin, alpine scutellarein, barbatrin, barbata seed, p-coumaric acid, Protocatechuic acid and other ingredients. [0003] For the preparation of traditional Chinese medicine formula granules from raw medicinal materials of Scutellaria barbata, many technical problems are face...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K47/26A61K47/36A61K36/539G01N21/31G01N1/38
CPCA61K9/1652A61K9/1623A61K36/539G01N21/3103G01N1/38
Inventor 周厚成代德蓉吴琦吴琴张玉婷胡昌江周维
Owner SICHUAN NEO GREEN PHARMA TECH DEV
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