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Application of transferrin receptor inhibitor Ferristatin-II in preparation of medicine for treating cerebral trauma

A receptor inhibitor, transferrin technology, applied in the field of medicine, can solve problems such as unclear mechanism of action and no reports of Ferristatin-II, and achieve the effect of improving iron deposition, improving lipid peroxidation, and reducing damage

Pending Publication Date: 2022-02-15
SUZHOU UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, the mechanism of ferroptosis in traumatic brain injury is unclear, and there has been no report of Ferristatin-II in the treatment of traumatic brain injury

Method used

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  • Application of transferrin receptor inhibitor Ferristatin-II in preparation of medicine for treating cerebral trauma
  • Application of transferrin receptor inhibitor Ferristatin-II in preparation of medicine for treating cerebral trauma
  • Application of transferrin receptor inhibitor Ferristatin-II in preparation of medicine for treating cerebral trauma

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Embodiment 1

[0042] (1) Drug preparation and administration method: Fer-II (Sigma Company, product number: C1144) was prepared at a concentration of 10 mg / kg with reference to the previous research basis and preliminary experimental results. The preparation method is as follows: according to the instructions, the Fer-II is prepared to the required concentration with medical physiological saline. Fer-II was administered by intraperitoneal injection 30 minutes to 1 hour after TBI, and administered once every 12 hours until the day before execution.

[0043] (2) Experimental grouping: There are the following five situations: ① TfR1 time-course change experiment after TBI, 6-week-old ICR mice were randomly divided into 9 groups, 6 in each group, grouped as: Sham, 12h, 12h+Fer-II , 1d, 1d+Fer-II, 2d, 2d+Fer-II, 3d and 3d+Fer-II. ② Nissl, FJB staining, Prussian blue and non-heme iron detection experiments, 6-week-old ICR mice were randomly divided into 3 groups, 6 mice in each group, and the gr...

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Abstract

The invention discloses an application of a transferrin receptor inhibitor Ferristatin-II in the preparation of a medicine for treating cerebral trauma. The time history change process of TfR1 expression after cerebral trauma and the influence of Ferristatin-II intervention on TfR1 expression are clarified, and the optimal treatment time of Ferristatin-II is determined; meanwhile, the Ferristatin-II is fed to the abdominal cavity 30 min to 1 h after the brain trauma, and it is proved that the Ferristatin-II relieves damage to neurons after the brain trauma by adopting a Nissl and FJB staining method; it is proved that Ferristatin-II influences iron metabolism related protein expression after brain trauma and has an improvement effect on brain iron content increase and iron deposition; it is proved that Ferristatin-II can significantly improve lipid peroxidation after TBI; in combination with an in-vitro experiment, the protection effect of Ferristatin-II is related to iron overload and lipid peroxide accumulation caused by reversing TBI; and a basis is provided for taking the Ferristatin-II as a novel medicine for treating the craniocerebral injury.

Description

technical field [0001] The invention relates to the application of a transferrin receptor inhibitor Ferristatin-II in the preparation of medicines for treating traumatic brain injury, and belongs to the technical field of medicine. Background technique [0002] Worldwide, more than 50 million people suffer a traumatic brain injury (TBI) each year, and about half of the population will suffer from one or more brain injuries during their lifetime. As an important cause of death and long-term disability in young patients, traumatic brain injury (TBI) has the characteristics of high incidence, high mortality and high disability rate, resulting in heavy social burden and serious public health problems. Although with the continuous development of science and technology and diagnosis and treatment, many clinical methods (such as surgical treatment, intracranial pressure reduction and anticonvulsions, etc.) are used to intervene in TBI, but they still cannot prevent the occurrence a...

Claims

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Application Information

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IPC IPC(8): A61K31/185A61P25/00
CPCA61K31/185A61P25/00
Inventor 罗承良程颖李晶李倩倩宋依婷
Owner SUZHOU UNIV
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