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Extraction and purification method of industrial hemp total terpene and preparation

A technology of industrial hemp and purification method, applied in the directions of non-active ingredient medical preparations, medical preparations containing active ingredients, and pill delivery, etc., can solve problems such as damage, low terpene extraction rate and purity, and reduce interference , The effect of process environmental protection

Pending Publication Date: 2022-02-18
HANYI BIO TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Existing technologies such as distillation and cold traps damage the final extract or require harsh conditions such as vacuum and low temperature, and the extraction rate and purity of terpenes are low

Method used

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  • Extraction and purification method of industrial hemp total terpene and preparation
  • Extraction and purification method of industrial hemp total terpene and preparation
  • Extraction and purification method of industrial hemp total terpene and preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] A method for extracting and purifying total terpenes of industrial hemp, comprising the following steps:

[0031] a) Industrial hemp medicinal material powder (unroasted industrial hemp leaves, industrial hemp flowers, industrial hemp roots, industrial hemp stem cores, industrial hemp seed meal or any combination of two or more) 100.00kg, add 8 times the amount of 80% ethanol was stirred and extracted at room temperature, and the extract was concentrated under reduced pressure at 60°C to obtain a concentrated solution;

[0032] b) After dispersing the concentrated solution by adding 6 times the amount of hot water, after cooling to room temperature, separate the supernatant by centrifugation;

[0033] c) Keep the supernatant liquid warm (temperature 90°C), carry out molecular distillation (pressure: -0.1Pa; temperature: 80°C; speed: 200rpm; condensation temperature: 10°C; distance between evaporation surface and condensation surface: 20mm), collect Light component, get...

Embodiment 2

[0036] A method for extracting and purifying total terpenes of industrial hemp, comprising the following steps:

[0037]a) Industrial hemp medicinal material powder (unroasted industrial hemp leaves, industrial hemp flowers, industrial hemp roots, industrial hemp stem cores, industrial hemp seed meal or any combination of two or more) 100.00kg, add 5 times the amount of 95% ethanol was stirred and extracted at room temperature, and the extract was concentrated under reduced pressure at 50°C to obtain a concentrated solution;

[0038] b) After dispersing the concentrated solution with 4 times the amount of hot water, after cooling to room temperature, separate the supernatant through centrifugation;

[0039] c) After keeping the supernatant liquid warm (temperature 80°C), carry out molecular distillation (pressure: -0.01Pa; temperature: 70°C; speed: 180rpm; condensation temperature: 5°C; distance between evaporation surface and condensation surface: 5mm), and collect Light com...

Embodiment 3

[0042] A method for extracting and purifying total terpenes of industrial hemp, comprising the following steps:

[0043] a) Industrial hemp medicinal material powder (unroasted industrial hemp leaves, industrial hemp flowers, industrial hemp roots, industrial hemp stem cores, industrial hemp seed meal or any combination of two or more) 100.00kg, add 10 times the amount of 50% ethanol was stirred and extracted at room temperature, and the extract was concentrated under reduced pressure at 70°C to obtain a concentrated solution;

[0044] b) After dispersing the concentrated solution by adding 8 times the amount of hot water, after cooling to room temperature, separate the supernatant by centrifuging and layering;

[0045] c) After keeping the supernatant liquid warm (temperature 95°C), carry out molecular distillation (pressure: -0.99Pa; temperature: 95°C; speed: 220rpm; condensation temperature: 15°C; distance between evaporation surface and condensation surface: 25mm), and col...

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Abstract

The invention belongs to the technical field of traditional Chinese medicine preparations, and discloses an extraction and purification method of industrial hemp total terpene and a preparation. The extraction and purification method comprises the following steps of: (1) stirring and extracting industrial hemp medicinal material powder with 50%-95% ethanol in an amount which is 5-10 times that of the industrial hemp medicinal material powder at room temperature, and concentrating an extracting solution under reduced pressure at a temperature of 50-70DEG C to obtain a concentrated solution; (2) adding 4-8 times of hot water into the concentrated solution for dispersion, performing cooling to room temperature, and performing centrifugal layering and separation to obtain supernatant; (3) carrying out heat preservation on the supernatant at 80-95DEG C, carrying out molecular distillation, and collecting light components to obtain an industrial hemp total terpene crude extract; and (4) taking the industrial hemp total terpene crude extract, adding 3-10 times of distilled water for steam distillation, collecting light components, performing standing at room temperature, and collecting the upper layer to obtain the industrial hemp total terpene extract with a total industrial hemp terpene content of greater than or equal to 95% and a transfer rate of greater than or equal to 99%. The method is environment-friendly in process, the extraction rate and the purity are higher than those of a traditional method for directly distilling medicinal materials with water vapor, and the obtained industrial hemp total terpene is suitable for being prepared into a medicinal preparation.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine preparations, in particular to an extraction and purification method and preparation of total terpenes of industrial hemp. Background technique [0002] The hemp plant is made up of various chemicals and compounds, about 200 of which are aromatic organic hydrocarbons, a group of compounds found in hemp that have a distinctive aroma and flavor called terpenes, or total terpenes of hemp . At present, more than 100 terpene components have been isolated and identified from industrial hemp, including α-pinene, myrcene, limonene, β-caryophyllene, linalool, humulene, ocimene, terpinene, etc. . Studies in recent years have found that industrial hemp terpenes have a variety of pharmacological activities, such as promoting relaxation and relieving stress, improving concentration and acuity, anti-tumor, antitussive, expectorant, antibacterial, local anesthesia, and treatment of colitis...

Claims

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Application Information

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IPC IPC(8): A61K36/60A61K47/69A61K9/16A61K9/48A61K9/20A61P25/00A61P25/28A61P35/00A61P11/14A61P11/10A61P31/04A61P21/02A61P1/00
CPCA61K36/60A61K47/6951A61K9/1652A61K9/4866A61K9/2059A61P25/00A61P25/28A61P35/00A61P11/14A61P11/10A61P31/04A61P21/02A61P1/00A61K2236/333A61K2236/37
Inventor 谭昕王曙宾孙武兴张景范德凯
Owner HANYI BIO TECH CO LTD
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