Extraction and purification method of industrial hemp total terpene and preparation

A technology of industrial hemp and purification method, applied in the directions of non-active ingredient medical preparations, medical preparations containing active ingredients, and pill delivery, etc., can solve problems such as damage, low terpene extraction rate and purity, and reduce interference , The effect of process environmental protection

Pending Publication Date: 2022-02-18
HANYI BIO TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Existing technologies such as distillation and cold traps damage the final extract or require harsh

Method used

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  • Extraction and purification method of industrial hemp total terpene and preparation
  • Extraction and purification method of industrial hemp total terpene and preparation
  • Extraction and purification method of industrial hemp total terpene and preparation

Examples

Experimental program
Comparison scheme
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[0029] Example 1

[0030] Extraction and purification method of industrial cannabis total terpene, which contains the following steps:

[0031] a) Industrial cannabis medicinal powder (industrial vestibular, industrial cannabis, industrial marijuana, industrial cannabis, industrial marijuana core, industrial marijuana core, industrial cannabis seed) 100.00kg, join Extraction extraction of 8 times of 80% ethanol is mixed, and the extract is concentrated under reduced concentrate under 60 ° C.

[0032] b) After the concentrate is added 6 times the amount of hot water, after cooling to room temperature, the upper layer is separated by centrifugation.

[0033] c) After thermal temperature (temperature 90 ° C), molecular distillation (pressure: -0.1Pa; temperature: 80 ° C; speed: 200 rpm; condensation temperature: 10 ° C; distance from evaporation surface and condensate: 20mm), collection Light components, the industrial cannipopene extract 0.225kg;

[0034] d) Take the industrial cann...

Example Embodiment

[0035] Example 2

[0036] Extraction and purification method of industrial cannabis total terpene, which contains the following steps:

[0037]a) Industrial cannabis medicinal powder (industrial vestibular, industrial cannabis, industrial marijuana, industrial cannabis, industrial marijuana core, industrial marijuana core, industrial cannabis seed) 100.00kg, join 5 times the amount of 95% ethanol mixed extraction, the extract was concentrated under reduced concentrate under 50 ° C;

[0038] b) After dispersion of the concentrate addition 4 times, after cooling to room temperature, the upper layer is separated by centrifugation;

[0039] c) After thermal temperature (temperature 80 ° C), molecular distillation (pressure: -0.01Pa; temperature: 70 ° C; rotational speed: 180 rpm; condensing temperature: 5 ° C; distance from evaporation surface and condensate: 5mm), collection Light component, the industrial cannipopene extract 0.210kg;

[0040] D) Take the industrial cannipopene crude...

Example Embodiment

[0041] Example 3

[0042] Extraction and purification method of industrial cannabis total terpene, which contains the following steps:

[0043] a) Industrial cannabis medicinal powder (industrial vestibular, industrial cannabis, industrial marijuana, industrial cannabis, industrial marijuana core, industrial marijuana core, industrial cannabis seed) 100.00kg, join The extraction of 10 times 50% ethanol is mixed, and the extract is concentrated under reduced pressure under 70 ° C;

[0044] b) After the concentrate is added 8 times the amount of hot water, after cooling to room temperature, the upper layer is separated by centrifugation;

[0045] c) After thermal temperature (temperature 95 ° C), molecular distillation (pressure: -0.99 Pa; temperature: 95 ° C; rotational speed: 220 rpm; condensing temperature: 15 ° C; distance from evaporation surface and condensate: 25mm), collection Light component, the industrial cannipopene extract 0.238kg;

[0046] d) Take the industrial cannip...

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Abstract

The invention belongs to the technical field of traditional Chinese medicine preparations, and discloses an extraction and purification method of industrial hemp total terpene and a preparation. The extraction and purification method comprises the following steps of: (1) stirring and extracting industrial hemp medicinal material powder with 50%-95% ethanol in an amount which is 5-10 times that of the industrial hemp medicinal material powder at room temperature, and concentrating an extracting solution under reduced pressure at a temperature of 50-70DEG C to obtain a concentrated solution; (2) adding 4-8 times of hot water into the concentrated solution for dispersion, performing cooling to room temperature, and performing centrifugal layering and separation to obtain supernatant; (3) carrying out heat preservation on the supernatant at 80-95DEG C, carrying out molecular distillation, and collecting light components to obtain an industrial hemp total terpene crude extract; and (4) taking the industrial hemp total terpene crude extract, adding 3-10 times of distilled water for steam distillation, collecting light components, performing standing at room temperature, and collecting the upper layer to obtain the industrial hemp total terpene extract with a total industrial hemp terpene content of greater than or equal to 95% and a transfer rate of greater than or equal to 99%. The method is environment-friendly in process, the extraction rate and the purity are higher than those of a traditional method for directly distilling medicinal materials with water vapor, and the obtained industrial hemp total terpene is suitable for being prepared into a medicinal preparation.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine preparations, in particular to an extraction and purification method and preparation of total terpenes of industrial hemp. Background technique [0002] The hemp plant is made up of various chemicals and compounds, about 200 of which are aromatic organic hydrocarbons, a group of compounds found in hemp that have a distinctive aroma and flavor called terpenes, or total terpenes of hemp . At present, more than 100 terpene components have been isolated and identified from industrial hemp, including α-pinene, myrcene, limonene, β-caryophyllene, linalool, humulene, ocimene, terpinene, etc. . Studies in recent years have found that industrial hemp terpenes have a variety of pharmacological activities, such as promoting relaxation and relieving stress, improving concentration and acuity, anti-tumor, antitussive, expectorant, antibacterial, local anesthesia, and treatment of colitis...

Claims

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Application Information

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IPC IPC(8): A61K36/60A61K47/69A61K9/16A61K9/48A61K9/20A61P25/00A61P25/28A61P35/00A61P11/14A61P11/10A61P31/04A61P21/02A61P1/00
CPCA61K36/60A61K47/6951A61K9/1652A61K9/4866A61K9/2059A61P25/00A61P25/28A61P35/00A61P11/14A61P11/10A61P31/04A61P21/02A61P1/00A61K2236/333A61K2236/37
Inventor 谭昕王曙宾孙武兴张景范德凯
Owner HANYI BIO TECH CO LTD
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