Application of gallic acid or gallic acid derivative in induction of differentiation and proliferation of neural stem cells
A neural stem cell and gallic acid technology, which is applied in the application field of gallic acid or its derivatives in inducing neural stem cell differentiation and proliferation, can solve the problem of lack of tolerance to acetylcholinesterase inhibitors, inability to completely cure diseases, and large side effects and other problems, to achieve the effect of significant neurotrophic activity
Pending Publication Date: 2022-03-01
龙健维(广州)医药科技有限公司
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Problems solved by technology
In related technologies, all clinical treatments for AD can only delay the progression of the disease, but cannot completely cure the disease
Common AD treatment drugs have relatively large side effects, such as: taking acetylcholinesterase inhibitors has a transient gastrointestinal reaction, and about one-third of patients do not have acetylcholinesterase inhibitor tolerance
Method used
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[0059] In order to make the object, technical solution and technical effect of the present invention clearer, the present invention will be further described in detail below in conjunction with specific embodiments. It should be understood that the specific implementations described in this specification are only for explaining the present invention, not for limiting the present invention.
[0060] The experimental materials and reagents used, unless otherwise specified, are conventional consumables and reagents that can be obtained from commercial channels.
[0061] experiment material
[0062] The test rats used in the following examples are all SPF grade Sprague-Dawley (SD) neonatal rats, purchased from Guangdong Medical Experimental Animal Center.
[0063]Culture of primary neural stem cells
[0064] Specific steps are as follows:
[0065] (1) Take 9 newborn SD rats whose birth time is less than 24 hours, and disinfect their heads after anesthesia. The skulls of newbor...
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The invention discloses application of gallic acid or a derivative thereof in induction of neural stem cell differentiation and proliferation, the inventor finds that the gallic acid or the derivative thereof can well induce neural stem cell differentiation and proliferation through research, and finds that the gallic acid or the derivative thereof regulates a calcium signal related pathway so as to regulate an action mechanism of NSC proliferation. Therefore, the original NSC in the brain can be induced in vitro to be transdifferentiated into neonatal neurons, a feasible clinical treatment scheme is provided for treating neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease, and the application prospect is extremely good.
Description
technical field [0001] The invention belongs to the field of medicine, in particular to the application of gallic acid or its derivatives in inducing differentiation and proliferation of neural stem cells. Background technique [0002] Alzheimer's disease (AD) is a neurodegenerative disease with insidious onset and progressive development. The main manifestations of patients are memory impairment, cognitive decline, language and behavioral decline, and severe cases I can't even take care of myself. AD damages mainly the brain areas related to cognition and memory function, among which the hippocampus in the medial temporal lobe has the most obvious lesion. The main pathological features are: senile plaques (SP) formed by the deposition of amyloid betaprotein (Aβ) outside the cells, and neurofibrillary tangles (NFTs) formed by the hyperphosphorylation of Tau protein in the cells. ) and loss of a large number of neurons. However, there is no definite mechanism to elucidate ...
Claims
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IPC IPC(8): A61K31/192A61K31/235A61P25/28A61P25/16A61P25/14A61P25/00A61P21/00
CPCA61K31/192A61K31/235A61P25/28A61P25/16A61P25/14A61P25/00A61P21/00
Inventor 不公告发明人
Owner 龙健维(广州)医药科技有限公司