Tresyl-chlorine modified FN implant micro-groove titanium sheet as well as preparation method and application thereof

A technology of micro-grooves and implants, used in dental implants, dental prosthetics, and devices for coating liquids on surfaces, etc. It can increase the adsorption of gingival fibroblasts, accelerate wound healing, and accelerate the growth of granulation tissue.

Pending Publication Date: 2022-03-01
泉州医学高等专科学校
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  • Description
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Problems solved by technology

[0002] It has been proved by experiments that the microgroove 60 microns wide and 10 microns deep titanium sheet for making oral implants has good hydrophilicity and biocompatibility, but its ability to adhere to plasma fibronectin is limited, which can promote the early stage of gingival fibroblasts. The adhesion of the implant has not reached the best, and the implant neck is not formed in time if a good soft tissue seal is not formed in the early stage of implant implantation, which will easily lead to the occurrence of infection

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  • Tresyl-chlorine modified FN implant micro-groove titanium sheet as well as preparation method and application thereof

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Embodiment Construction

[0023] In order to make the technical means, creative features, goals and effects achieved by the present invention easy to understand, the present invention will be further described below in conjunction with specific embodiments.

[0024] The present invention provides a technical solution for the preparation method of Tresyl-chlorine-modified FN implant microgroove titanium sheet: the preparation method is as follows:

[0025] The first part: surface treatment of titanium sheet;

[0026] The first sub-part: Ultrasonic cleaning of the titanium sheet, ultrasonic cleaning with acetone at normal temperature and pressure for 3 minutes, and then ultrasonic cleaning in primary water for 5 minutes;

[0027] The second sub-part: Soak the titanium sheet treated in the first sub-part in absolute ethanol for 2 hours at normal temperature and pressure, rinse with sterilized first-class water, and irradiate with ultraviolet rays for 30 minutes;

[0028] The third subsection: finally cov...

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Abstract

The invention discloses a Tresyl-chlorine modified FN implant micro-groove titanium sheet and a preparation method and application thereof.The Tresyl-chlorine activates terminal hydroxyl existing on the exposed titanium surface and promotes FN protein adsorption, the titanium sheet treated with the Tresyl-chlorine can improve the plasma FN adsorption rate of the titanium sheet, formation of soft tissue around an implant is facilitated, and the implant micro-groove titanium sheet has the advantages that the implant micro-groove titanium sheet can be used for preparing the implant micro-groove titanium sheet with the FN modified with the Tresyl-chlorine. The FN protein can promote the migration of fibroblasts and epithelial cells, accelerate the growth of granulation tissues and accelerate wound healing in wound healing, so that the micro-groove titanium sheet treated by Tresyl-chlorine can increase gingival fibroblast adsorption, shorten the implant soft tissue healing time and improve the healing effect of the implant. And the neck is promoted to form good soft tissue closure in the early stage of implantation.

Description

technical field [0001] The invention relates to a Tresyl-chlorine-modified FN implant micro-groove titanium sheet and a preparation method and application thereof, belonging to the field of titanium sheet preparation. Background technique [0002] It has been proved by experiments that the micro-groove 60 microns wide and 10 microns deep titanium sheet for making oral implants has good hydrophilicity and biocompatibility, but its ability to adhere to plasma fibronectin is limited, and it can promote the early stage of gingival fibroblasts. The adhesion of the implant has not reached the best, and if the implant neck does not form a good soft tissue closure in time in the early stage of implant placement, it is easy to lead to infection. Contents of the invention [0003] In view of the deficiencies in the prior art, the object of the present invention is to provide a Tresyl-chlorine-modified FN implant micro-groove titanium sheet and its preparation method and application,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B05D7/24B05D7/14A61C8/00
CPCB05D7/24B05D7/14A61C8/0012
Inventor 黄斯佳
Owner 泉州医学高等专科学校
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