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Application of ethyl p-hydroxybenzoate to resistance to coronavirus infection

A technology of ethyl hydroxybenzoate and coronavirus, which is applied in the field of medicine, can solve problems such as no reports and achieve good drug efficacy

Pending Publication Date: 2022-03-08
INCREASEPHARM HENGQIN INST CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no report about the above-mentioned applications, especially the application of ethyl p-hydroxybenzoate in the treatment of human coronavirus HCoV-229E infection diseases

Method used

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  • Application of ethyl p-hydroxybenzoate to resistance to coronavirus infection
  • Application of ethyl p-hydroxybenzoate to resistance to coronavirus infection
  • Application of ethyl p-hydroxybenzoate to resistance to coronavirus infection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0086] Embodiment 1 Butyl p-hydroxybenzoate atomized inhalation preparation

[0087] Butyl p-hydroxybenzoate 0.2g

[0088] Sodium chloride 9.0g

[0089] Add water for injection to 1000ml

[0090] Preparation Process:

[0091] Step 1: Weigh 0.2g of butyl p-hydroxybenzoate and 9.0g of sodium chloride, add 1000ml of water for injection at 20°C to 35°C, dilute, stir evenly, and filter through a 0.22μm microporous membrane;

[0092] Step 2: Fill and seal in ampoules, and sterilize with high pressure steam at 115°C for 30 minutes.

Embodiment 2

[0093] Embodiment 2 Propyl p-hydroxybenzoate atomized inhalation preparation

[0094] Propylparaben 0.2g

[0095] Sodium chloride 9.0g

[0096] Add water for injection to 1000ml

[0097] Preparation Process:

[0098] Step 1: Weigh 0.2 g of propyl p-hydroxybenzoate and 9.0 g of sodium chloride, add 1000 ml of water for injection at 20°C to 35°C, dilute, stir evenly, and filter through a 0.22 μm microporous membrane;

[0099] Step 2: Fill and seal in ampoules, and sterilize with high pressure steam at 115°C for 30 minutes.

Embodiment 3

[0100] Embodiment 3 Ethyl p-hydroxybenzoate atomized inhalation preparation

[0101] Ethyl p-hydroxybenzoate 0.2g

[0102] Sodium chloride 9.0g

[0103] Add water for injection to 1000ml

[0104] Preparation Process:

[0105] Step 1: Weigh 0.2g of ethyl p-hydroxybenzoate and 9.0g of sodium chloride, add 1000ml of water for injection at 20°C to 35°C, dilute, stir evenly, and filter through a 0.22μm microporous membrane;

[0106] Step 2: Fill and seal in glass ampoules, and sterilize with high-pressure steam at 115°C for 30 minutes.

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Abstract

The invention belongs to the field of drug treatment, and particularly relates to application of ethyl p-hydroxybenzoate in preparation of drugs for preventing or treating virus infectious diseases. The invention discloses application of ethyl p-hydroxybenzoate and an inhalation preparation thereof in treatment of coronavirus infectious diseases. The new application of the ethyl p-hydroxybenzoate inhalation solution is verified in a mouse test infected with human coronavirus HCoV-229E, the technical scheme has novelty, a curative effect test of the m-cresol inhalation solution in treatment of pneumonia caused by HCoV-229E virus infection is carried out, and the result shows that the m-cresol inhalation solution can be used for treating pneumonia caused by HCoV-229E virus infection. The ethyl p-hydroxybenzoate inhalation solution shows a good drug effect on the lung index and the inhibition rate of a pneumonia mouse infected with the HCoV-229E virus, and the lung index of the mouse can be remarkably reduced.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of ethyl p-hydroxybenzoate in the preparation of drugs for preventing or treating coronavirus infectious diseases. Background technique [0002] [0003] Ethyl p-hydroxybenzoate (C 9 h 10 o 3 ) also known as ethyl paraben, molecular weight 166.18. [0004] As antiseptic and bacteriostatic agent, ethylparaben is widely used in cosmetics, food, oral preparations and topical preparations. It can be used alone or in combination with other parabens and other antibacterial preservatives. It is one of the most commonly used antibacterial preservatives in cosmetics. Ethyl p-hydroxybenzoate can have antibacterial activity in the range of pH 4 to 8. Due to the formation of phenoxide anion, the antiseptic effect decreases with the increase of pH. It has broad-spectrum antibacterial activity, and its lethality ratio to yeast and mold Bacteria are strong, and the anti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/216A61P31/14
CPCA61K31/216A61P31/14
Inventor 李艳英李翠李文慧许彦
Owner INCREASEPHARM HENGQIN INST CO LTD
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