Unlock instant, AI-driven research and patent intelligence for your innovation.

Soluble double-layer drug-loaded microneedle patch for chronic wound repair and preparation method of soluble double-layer drug-loaded microneedle patch

A chronic wound, soluble technology, applied in the field of biomedical materials, can solve the problems of low drug loading rate, inability to achieve multi-functional treatment, etc., to achieve the effect of promoting accelerated healing

Pending Publication Date: 2022-03-11
SOUTHWEST JIAOTONG UNIV
View PDF1 Cites 5 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the structural design of microneedles is mostly an integrated structure, and generally only the needle tip is loaded with drugs, the drug loading rate is low and the effect of multifunctional treatment cannot be achieved

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Soluble double-layer drug-loaded microneedle patch for chronic wound repair and preparation method of soluble double-layer drug-loaded microneedle patch
  • Soluble double-layer drug-loaded microneedle patch for chronic wound repair and preparation method of soluble double-layer drug-loaded microneedle patch
  • Soluble double-layer drug-loaded microneedle patch for chronic wound repair and preparation method of soluble double-layer drug-loaded microneedle patch

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0044] Embodiment: This embodiment provides a dissolvable double-layer drug-loaded microneedle patch for chronic wound repair, including a tip containing recombinant human epidermal growth factor, and a backing layer containing tetracycline hydrochloride, the tip and the backing layer The liner is integrally connected to form a double-layer drug-loaded patch microneedle.

[0045] Specifically, the tip containing human recombinant epidermal growth factor also contains a polymer matrix material. In this embodiment, the polymer matrix material is carboxymethyl chitosan, gelatin, carboxymethyl chitosan as biological Dissolving materials with good compatibility, used to obtain a certain release rate of human recombinant epidermal growth factor; carboxymethyl chitosan is easily soluble in water, and also has more prominent antifungal activity and certain healing factors, namely Methyl chitosan exhibits antibacterial effect, non-irritating and good fluidity, and can play a role in wo...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Molecular weightaaaaaaaaaa
Login to View More

Abstract

The invention relates to the technical field of biomedical materials, and discloses a soluble double-layer drug-loaded microneedle patch for chronic wound repair and a preparation method of the soluble double-layer drug-loaded microneedle patch. The double-layer drug-loading microneedle patch comprises a tip containing a polymer matrix material and a backing layer containing antibacterial and anti-inflammatory drugs, the tip and the backing layer are integrally connected to form a double-layer drug-loading patch microneedle, and the soluble microneedle patch with different dissolution speeds is formed through the backing layer and the tip of a needle tip. The traditional Chinese medicine composition respectively participates in verification and proliferation stages for regulating wound healing, achieves antibacterial and anti-inflammatory effects in an inflammation stage, induces angiogenesis in the proliferation stage and promotes epithelial cell differentiation, so that the wound healing process is accelerated.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a soluble double-layer drug-loaded microneedle patch for chronic wound repair and a preparation method thereof. Background technique [0002] The process of wound healing generally includes the following four stages: hemostasis stage, inflammation stage, proliferation stage, and remodeling stage. But chronic wounds heal slowly, partly because of infection and a lack of functional growth factors at the wound site. At present, wound repair is mainly based on debridement and hemostasis, sedation and pain relief, surgical suture, etc., but these existing repair methods cannot adjust the different stages of wound healing, and can only intervene in a specific stage, which cannot achieve the ideal effect. Accelerated wound healing effect. [0003] Microneedle therapy is a minimally invasive, painless and efficient transdermal therapy that can form a large number of microp...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K38/18A61K31/722A61K31/65A61K45/06A61K9/70A61K47/36A61K47/42A61P17/02A61P29/00A61P31/04A61P31/10A61M37/00
CPCA61K38/1808A61K31/722A61K31/65A61K45/06A61K9/7023A61K47/36A61K47/42A61K9/0021A61P17/02A61P29/00A61P31/04A61P31/10A61M37/0015A61M2037/0046A61M2037/0053A61K2300/00
Inventor 陈星羽刘伟翁杰
Owner SOUTHWEST JIAOTONG UNIV
PatSnap Eureka logo

PatSnap Eureka turns technology decisions into work you can execute. Powered by our Innovation Knowledge Graph, it runs expert workflows across engineering, life sciences, materials and intellectual property. Get your review-ready output in minutes.

X (Twitter)LinkedInYouTubeSubstack

© 2026 PatSnap. All rights reserved. 

Terms of Service

 | 

Privacy policy

 | 

Modern Slavery Act Transparency Statement