Peramivir pharmaceutical composition and preparation method thereof
A composition and medicine technology, applied in the field of peramivir pharmaceutical composition and preparation thereof, can solve the problems of high production cost and price of peramivir, and achieve the effects of good market prospect, simple process and low cost
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preparation example Construction
[0032] The embodiment of this application provides a kind of preparation method of peramivir pharmaceutical composition, and preparation method comprises:
[0033] S100, dissolving peramivir in an organic solvent to obtain an oil phase solution;
[0034] S200, dissolving the excipient in water for injection to obtain an aqueous phase solution;
[0035] S300. Adding the aqueous phase solution into the oil phase solution dropwise, ultrasonic emulsification, and adding water for injection to obtain a peramivir pharmaceutical composition as an injection.
[0036] In some embodiments of the present application, the preparation method also includes:
[0037] S400. Sterilize and package the peramivir pharmaceutical composition.
[0038] It should be noted that the raw materials of peramivir used in the examples of this application can be purchased through commercial channels.
[0039] In some embodiments of the present application, S100 includes:
[0040] S110, according to the m...
Embodiment 1
[0068] This embodiment provides a preparation method of the peramivir pharmaceutical composition, specifically as follows.
[0069] S1-1. According to the mass ratio of peramivir:organic solvent=20:100, the peramivir was dissolved in the organic solvent at a temperature of 60° C. to obtain an oil phase solution. The organic solvent includes: nicotinamide, 5 parts by mass; polyoxyethylene castor oil, 45 parts by mass; ethyl oleate, 50 parts by mass.
[0070] S1-2. Dissolving the excipients in the water for injection according to the mass ratio of excipients: water for injection = 16:100 to obtain an aqueous phase solution. The auxiliary materials include: sodium sulfite, 8 parts by mass, and polysorbate, 8 parts by mass.
[0071] S1-3. According to the mass ratio of water phase solution: oil phase solution=40:100, the water phase solution is added dropwise into the oil phase solution and ultrasonically emulsified and supplemented with water for injection to obtain the peramivi...
Embodiment 2
[0073] This embodiment provides a preparation method of the peramivir pharmaceutical composition, specifically as follows.
[0074] S2-1. According to the mass ratio of peramivir: organic solvent = 30:100, the peramivir is dissolved in the organic solvent at a temperature of 65° C. to obtain an oil phase solution. The organic solvent includes: nicotinamide, 10 parts by mass; polyoxyethylene castor oil, 50 parts by mass; ethyl oleate, 40 parts by mass.
[0075] S2-2. Dissolving the excipients in the water for injection according to the mass ratio of excipients: water for injection = 20:100 to obtain an aqueous phase solution. The auxiliary materials include: sodium sulfite, 10 parts by mass, and polysorbate, 10 parts by mass.
[0076] S2-3, according to the mass ratio of water phase solution: oil phase solution=60:100, the water phase solution is added dropwise into the oil phase solution and ultrasonically emulsified and supplemented with water for injection to obtain the per...
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Abstract
Description
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Application Information
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