Bimetal nanostructure antibacterial composition and preparation method thereof

An antibacterial composition and a bimetallic nanotechnology are applied in the field of bimetallic nanostructured antibacterial compositions and their preparation, which can solve the problems of antibacterial test verification, unknown antibacterial effect, not reaching ug/mL and the like, and achieve good antibacterial activity. , Low toxicity and side effects, significant inhibitory effect

Pending Publication Date: 2022-03-25
GUANGDONG PHARMA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, none of the above-mentioned patent applications has carried out antibacterial test verification on the obtained product, and its antibacterial effect is unknown.
However, the effective antibacterial concentration of currently synthesized MOFs materials is still in the range of 5-10 mg / mL, and has not yet reached the level of ug / mL or even lower.

Method used

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  • Bimetal nanostructure antibacterial composition and preparation method thereof
  • Bimetal nanostructure antibacterial composition and preparation method thereof
  • Bimetal nanostructure antibacterial composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Embodiment 1: A kind of preparation method of bimetallic nanostructure antibacterial composition

[0037] 1.351g FeCl 3 ·6H 2 O (5mmol) and 0.415g (2.5mmol) terephthalic acid (H 2 BDC) were mixed in 30mL dimethylamide (DMF), ultrasonicated for 15min to make it a cloudy suspension, and then 0.3532g of silver nitrate (H 2 BDC and FeCl 3 ·6H 220% of O mass), add 6mL of 70 ℃ dehydrated ethanol, then join the dehydrated ethanol containing silver nitrate in the turbid suspension; the suspension is sealed in the stainless steel reactor with Teflon liner , After heating at 120°C for 24h, an orange sludge was obtained, which was separated by centrifugation (4000rmp, 10min) to obtain an orange sludge; the orange sludge was treated with DMF (washed once) and hot ethanol (washed twice at 70°C) Wash and centrifuge (4000rmp, 15min) to remove unreacted raw materials, and activate the cleaned orange sludge at 150°C for 12h to obtain 20% MIL-101(Fe)@Ag.

[0038] Among them, the Fe...

Embodiment 2

[0040] The preparation method described in embodiment 2 is similar to embodiment 1, and difference is that the amount of adding silver nitrate is FeCl 3 ·6H 2 2% of the mass of both O and terephthalic acid.

Embodiment 3

[0042] The preparation method described in embodiment 3 is similar to embodiment 1, and difference is that the amount of adding silver nitrate is FeCl 3 ·6H 2 10% of the mass of both O and terephthalic acid.

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PUM

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Abstract

The invention belongs to the field of nano materials, and particularly relates to a bimetallic nano-structure antibacterial composition and a preparation method thereof. The synthesized nano material MIL-101 (Fe) (at) Ag is regular in crystal morphology, has a three-dimensional structure, is uniform in particle distribution, and has a remarkable inhibition effect on escherichia coli and staphylococcus aureus. The antibacterial property of the synthetic product is detected by a plate coating method, and when the concentration of MIL-101 (Fe) coated Ag is 100 mu g / mL, the inhibition effect on escherichia coli and staphylococcus aureus is remarkable.

Description

technical field [0001] The invention belongs to the field of nanometer materials, and in particular relates to a bimetallic nanostructure antibacterial composition and a preparation method thereof. Background technique [0002] Metal-organic frameworks (MOFs) are novel topological materials bridged by multidentate organic ligands and metal ions or metal clusters. This type of material not only has a high specific surface area and a large pore volume, but also can synthesize materials with different pore sizes by changing the ligand type, and design materials purposefully according to different needs. From the first synthesis to now, MOFs materials have synthesized a variety of crystal types, covering six categories, including ZIF series materials, MIL series materials, etc. At present, MOFs are widely used in energy storage materials, gas adsorption and separation, catalysis, sensing, magnetism, fluorescence and other fields. Due to the characteristics of MOFs structure, i...

Claims

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Application Information

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IPC IPC(8): A01N59/16A01P1/00
CPCA01N59/16
Inventor 刘甜恬黎奚徐梦媛陈捷晗郑惠莹林夏子
Owner GUANGDONG PHARMA UNIV
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