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Biomarker for white matter lesion and application thereof

A biomarker and white matter technology, applied in the field of biomarkers for white matter lesions, can solve the problems of high cost and expensive detection equipment, and achieve the effects of cost reduction and accurate detection results.

Active Publication Date: 2022-03-25
BAO FENG BIOTECH (BEIJING) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the detection equipment used is expensive and costs a lot

Method used

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  • Biomarker for white matter lesion and application thereof
  • Biomarker for white matter lesion and application thereof
  • Biomarker for white matter lesion and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] (1) Patient population standard

[0036] The model establishment sample group was 78 people. The control group: there were no abnormalities in the MRI nuclear magnetic resonance examination, and the age range was above 45, a total of 29 people.

[0037] Patient population: 49 patients with an age range of 45 and above showed infarcts in the white matter of the brain as detected by MRI.

[0038] (2) Model establishment

[0039] 1. Sample pretreatment

[0040] The clinical information and serum samples of the above population were collected, 200 μL of serum was extracted with 600 μL of pre-cooled isopropanol, vortexed with a vortex oscillator (MX-S, Scilogex, USA) for 1 min, incubated at room temperature for 10 min, and then the extraction mixture was placed in- Store overnight at 20°C, centrifuge at 4000rr for 20min in a refrigerated centrifuge (D3024R, Scilogex, USA), transfer the supernatant to a new centrifuge tube, and wash with isopropanol / acetonitrile / water (2:1:...

Embodiment 2

[0070] The logistic regression model established in Example 1 was verified using an external data set. The model verification sample group was 130 people, and the sampling standard was the same as that in Example 1. There were 85 patients and 45 normal controls. Use the method in Example 1 to perform ultra-high performance liquid chromatography-mass spectrometry to detect the above five biomarkers in serum and combine them with any one of fasting blood glucose, homocysteine, glycosylated hemoglobin, cholesterol and body weight Item or two indicators, to verify the accuracy of the model results in Example 1, and draw the corresponding ROC curve, the results are as follows:

[0071] "Model A" variable is R1+R20+K9, and the result of the ROC curve is as follows Figure 4 , Sensitivity (sensitivity)=1, Specificity (specificity)=1, Accuracy (accuracy)=1.

[0072] "Model B" variable is R1+R14+K3+K9, the result of the ROC curve is as follows Figure 5 As shown, Sensitivity (sensiti...

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PUM

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Abstract

The invention provides a biomarker for white matter lesion and application thereof, and particularly relates to application of a biomarker ceramide (d18: 0 / 24: 1 (15Z)) in preparation of a detection reagent for diagnosing white matter lesion. The risk of the white matter lesion is judged by combining a biomarker lipoceramide (d18: 0 / 24: 1 (15Z)) with one or two of PEIPC, phosphatidylcholine (P-18: 1 (9Z) / 0: 0), phosphatidylcholine (O-18: 0 / 0: 0) or galactosylceramide (d18: 0 / 16: 0), and the white matter lesion can be prevented in advance.

Description

technical field [0001] The invention belongs to the technical field of biological detection, and in particular relates to a biomarker of cerebral white matter lesion and application thereof. Background technique [0002] White matter is an important part of the central nervous system, where nerve fibers gather. Damage to the myelin sheath of central nerve cells in white matter can cause white matter lesions. White matter lesions mainly cause symptoms such as cognitive impairment, speech impairment, abnormal mental behavior, gait disorder, and urination disorder, which seriously affect the quality of life of patients. It is strongly associated with an increased risk of stroke and dementia. Factors such as hypertension, diabetes, dyslipidemia, and metabolic disorders are also closely related to the onset and progression of white matter lesions, and these metabolic diseases mainly occur in the elderly population. In general, the condition of most patients with white matter le...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N30/06G01N30/86G16H50/30
CPCG01N30/02G01N30/06G01N30/8675G01N30/8651G16H50/30G01N2030/062
Inventor 陈显扬宋王婷常婷婷
Owner BAO FENG BIOTECH (BEIJING) CO LTD
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