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Interleukin 37-based early warning of respiratory virus infection (risk)

A technology of virus infection and interleukin, which is applied in the direction of epidemic warning system, disease diagnosis, microbial measurement/inspection, etc., and can solve the problems of no quantifiable judgment standards

Pending Publication Date: 2022-03-29
SHANGHAI PUBLIC HEALTH CLINICAL CENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It can be seen that similar early warning indicators do not have a clear and quantifiable judgment standard, and more accurate severe early warning methods are urgently needed

Method used

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  • Interleukin 37-based early warning of respiratory virus infection (risk)
  • Interleukin 37-based early warning of respiratory virus infection (risk)
  • Interleukin 37-based early warning of respiratory virus infection (risk)

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0147] Example 1, Plasma Interleukin in Patients with New Coronary Pneumonia 37 levels with Strong relationship with clinical outcome

[0148] The plasma samples of patients tested in this example were obtained from 254 randomly selected patients who were diagnosed with COVID-19 through positive viral nucleic acid tests from February 2020 to May 2020 at the Shanghai Public Health Clinical Center. The age of the patients was 42.76±0.95, including 114 females and 140 males. This study was approved by the Ethics Committee, and all enrolled patients signed informed consent.

[0149] The plasma of the above 254 patients with new coronary pneumonia at the earliest admission (before therapeutic intervention) was selected for freezing and thawing, and the plasma of 36 healthy individuals was used as a control. Zhengbai Biotechnology Co., Ltd.) for quantitative analysis of plasma interleukin-37 levels, the detection method was carried out according to the kit instructions, and the...

Embodiment 2

[0166] Example 2, Plasma Interleukin 37 Levels and Inflammatory Indexes Interleukin 6 (IL-6), Interleukin 8 in Patients with New Coronary Pneumonia (IL-8) and high-sensitivity C-reactive protein (HS-CRP) were significantly negatively correlated

[0167] The source of patient plasma used in this example is the same as that in Example 1.

[0168] The correlation between plasma interleukin-37 levels and inflammation-related indicators in patients with new coronary pneumonia was further explored, including HS-CRP, IL-6 and IL-8. 8 The test results come from the plasma cytokine test results. The test method uses the Simoa CorPlex Human Cytokine Detection Kit to measure the levels of IL-6 and IL-8 in the patient's plasma. The operation steps are based on the experimental procedures of the American manufacturer Quanterix.

[0169] A linear correlation regression analysis was carried out, and the results showed that the plasma interleukin-37 level of the patient was related to the...

Embodiment 3

[0172] Example 3, interleukin 37, hypersensitive C-reactive protein (HS-CRP) and interleukin 6 (IL-6) jointly predict new coronary pneumonia (Critical) critically ill patients

[0173] The ROC related charts were all calculated by SPSS software, and the charts were drawn by Medcalc software.

[0174] A. Two-Factor Combination of Interleukin-37 and High Sensitive C-Reactive Protein (HS-CRP)

[0175] The interleukin-37 secretion value and the HS-CRP secretion value of the patient measured in Example 1 are jointly used as independent variables, and the (mild) moderate and (critical) severe diseases are used as dependent variables to carry out binary Logistic regression analysis modeling, The joint prediction probability of interleukin-37 and HS-CRP was obtained.

[0176] The results of the ROC curve are as follows image 3 As shown in the IL_37_HS_CRP curve, the test parameters corresponding to each ROC curve include sensitivity, specificity, area under the curve, standar...

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Abstract

The invention provides an interleukin 37-based early warning of respiratory virus infection (risk). Specifically, the invention provides an application of a substance for detecting the level of interleukin 37 in a sample in preparation of a product (such as a kit or a detection system) for prognosis evaluation of respiratory virus infection, and a corresponding product, system and method thereof. According to the application, the interleukin 37 is taken as a basic evaluation index, the accuracy and the specificity of severe case prediction are remarkably improved, the severe case occurrence rate and the death rate after respiratory virus infection can be effectively reduced, and the method has important clinical application value and wide application prospect.

Description

technical field [0001] This application is in the field of biodiagnostics, immunology and medical data analysis. Specifically, this application relates to a quantifiable, interleukin-37-based model, method and related products capable of clinical early warning of (critically) critically ill patients after respiratory virus infection. Background technique [0002] Globally, acute respiratory diseases account for a large proportion of all acute morbidity and mortality, with acute viral respiratory infections being the leading cause. According to the statistics of the World Health Organization, whether in developed countries or developing countries, urban children suffer from 4 to 8 acute respiratory infections per person per year on average, and the main viral pathogens include influenza virus, coronavirus, rhinovirus, and respiratory syncytial virus and adenovirus. Influenza virus epidemics of different scales occur every year. According to the data of the World Health Orga...

Claims

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Application Information

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IPC IPC(8): C12Q1/6883G01N33/68G16H50/80
CPCC12Q1/6883G01N33/6893G01N33/6869G16H50/80G01N2333/54G01N2800/12G01N2800/52C12Q2600/158C12Q2600/118
Inventor 徐建青张晓燕李昂
Owner SHANGHAI PUBLIC HEALTH CLINICAL CENT
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