Traditional Chinese medicine composition for treating Crohn's disease and application thereof

A composition and technology of traditional Chinese medicine, applied in the field of traditional Chinese medicine composition, can solve the problems of affecting curative effect, poor patient compliance, poor curative effect, etc., and achieve the effect of promoting mucosal healing

Active Publication Date: 2022-04-08
GUANGDONG HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Enteral nutrition therapy includes complete enteral nutrition (exclusive enteral nutrition, EEN) and partial enteral nutrition (partial enteral nutrition, PEN). EEN refers to stopping eating natural food during treatment and taking artificial synthetic nutrients to meet the body's metabolic needs ; The commonly used methods are oral or tube feeding, which has a supportive treatment effect on CD; but EEN has poor taste and poor patient compliance, which affects the curative effect.
PEN refers to giving EN as a supportive treatment for energy supplementation while eating (diet structure adjustment). The patient's compliance is better than that of EEN, but the efficacy of supportive treatment with PEN is worse than that of EEN.

Method used

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  • Traditional Chinese medicine composition for treating Crohn's disease and application thereof
  • Traditional Chinese medicine composition for treating Crohn's disease and application thereof
  • Traditional Chinese medicine composition for treating Crohn's disease and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] A Chinese medicine composition for treating Crohn's disease, said Chinese medicine composition comprising the following raw materials:

[0048] Agrimony 45g, Niu Dali 60g, Pueraria 30g, Atractylodes macrocephala 15g, Poria cocos 30g, coix seed 15g, forsythia 5g, capillary wormwood 10g, angelica 5g, gallinaceae 20g, silkworm 5g, yizhiren 20g, moutan bark 5g , Fritillaria 30g, ginger 10g.

[0049] The preparation method of described Chinese medicine composition comprises the following steps:

[0050] (1) Boil Agrimony, Niu Dali, and simmered kudzu root with 1-1.5L of water;

[0051] (2) Add Atractylodes macrocephala, Poria cocos, coix seed, forsythia, angelica, gallinacea, silkworm, Yizhi kernel, Moutan bark, Fritillaria fritillaria, ginger in step (1), and continue to decoct;

[0052] (3) Continue to add capillary capillary in step (2), decoct until 400ml.

Embodiment 2

[0054] A Chinese medicine composition for treating Crohn's disease, said Chinese medicine composition comprising the following raw materials:

[0055] Agrimony 35g, Niu Dali 40g, Kudzu root 40g, Atractylodes macrocephala 20g, Poria cocos 20g, coix seed 18g, forsythia 15g, capillary 8g, angelica 7g, gallinaceae 15g, silkworm 6g, yizhiren 12g, moutan bark 6g , Fritillaria 18g, ginger 12g.

[0056] The preparation method of this Chinese medicine composition is identical with embodiment 1.

Embodiment 3

[0058] A Chinese medicine composition for treating Crohn's disease, said Chinese medicine composition comprising the following raw materials:

[0059] Agrimony 40g, Niu Dali 50g, Kudzu root 45g, Atractylodes macrocephala 18g, Poria cocos 25g, coix seed 16g, forsythia 8g, capillary wormwood 12g, angelica 8g, gallinaceae 18g, silkworm 7g, yizhiren 18g, moutan bark 7g , Fritillaria 20g, ginger 13g.

[0060] The preparation method of this Chinese medicine composition is identical with embodiment 1.

[0061] Typical cases:

[0062] Case 1: Liu, male, 34 years old, admitted to Guangdong Provincial Hospital of Traditional Chinese Medicine: 2020-07-28.

[0063] Condition introduction: Abdominal pain for more than 2 months. In July 2017, the patient developed swelling and pain on the right side of the anus after eating spicy food. At that time, there was no fever and chills, no ulceration and pus, and the anal mass prolapsed after no stool. The next day, fever occurred Aversion to c...

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PUM

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Abstract

The invention belongs to the technical field of traditional Chinese medicine compositions, and particularly relates to a traditional Chinese medicine composition for treating Crohn's disease and application thereof. The invention discloses a traditional Chinese medicine composition for treating Crohn's disease. The traditional Chinese medicine composition is prepared from the following raw materials: 30 to 60 g of herba agrimoniae, 30 to 60 g of radix millettiae speciosae, 30 to 60 g of roasted radix puerariae, 15 to 30 g of rhizoma atractylodis macrocephalae, 15 to 30 g of poria cocos, 10 to 30 g of semen coicis, 5 to 15 g of fructus forsythiae, 5 to 15 g of herba artemisiae scopariae, 5 to 10 g of radix angelicae sinensis, 15 to 20 g of endothelium corneum gigeriae galli, 5 to 10 g of stiff silkworm, 10 to 20 g of fructus alpiniae oxyphyllae, 5 to 10 g of cortex moutan, 15 to 30 In the traditional Chinese medicine composition, hairyvein agrimony and beautiful millettia root serve as monarch drugs, bighead atractylodes rhizome, poria cocos, fructus alpiniae oxyphyllae and stewed radix puerariae serve as ministerial drugs, fructus forsythiae, moutan bark, stiff silkworm, thunberg fritillary bulb and angelica sinensis serve as adjuvant drugs, and oriental wormwood, endothelium corneum gigeriae galli and coix seeds serve as conductant drugs. Through the compatibility of monarch, minister, assistant and guide, the traditional Chinese medicine composition has the effect of inducing and relieving Crohn disease patients and has the tendency of promoting mucous membrane healing.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine compositions, and in particular relates to a traditional Chinese medicine composition for treating Crohn's disease and its application. Background technique [0002] Crohn's disease (CD) is an intestinal inflammatory disease of unknown cause, which can occur in any part of the gastrointestinal tract, but mostly occurs in the terminal ileum and right colon, and the etiology of the disease is currently unknown. Crohn's disease is a proliferative lesion that runs through all layers of the intestinal wall, can invade the mesentery and regional lymph nodes, and is limited to the small intestine (mainly the terminal ileum) and colon. The lesions of this disease are segmentally distributed, separated from normal intestinal segments, with clear boundaries, and are characterized by skip areas. The pathological changes are divided into acute inflammation phase, ulcer formation phase, s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9068A61P1/04A61P1/00A61K35/57A61K35/64
CPCY02A50/30
Inventor 黄智斌陈延陈水林何家鸣刘刚胡锦辉
Owner GUANGDONG HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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