Method for separating and purifying dencichine from legume plants

A technology for purifying notoginseng and notoginseng, which is applied in the separation/purification of carboxylic acid amides, chemical instruments and methods, organic chemistry, etc., and can solve problems affecting the utilization of notoginseng, environmental pollution, time-consuming and laborious, etc.

Pending Publication Date: 2022-04-12
TIANSHUI NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] However, the above-mentioned methods all need to use a large amount of organic solvents, some of which also involve heavy metal salts, which cause great pollution to the environment, and some of the reaction steps are numerous, time-consuming and laborious, which affects the further utilization of the proposed notoginseng

Method used

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  • Method for separating and purifying dencichine from legume plants
  • Method for separating and purifying dencichine from legume plants
  • Method for separating and purifying dencichine from legume plants

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-1

[0066] Example 1-1: Extraction and purification of notoginseng

[0067] 1. Soak

[0068] Select Lathyrus bean seeds with full grains and no damage, and accurately weigh 500g (m 1 ), first scrub with tap water to remove dust and other impurities on the surface of the seeds; then wash three times with deionized water in the same way, and soak in 1L of deionized water for 6h.

[0069] 2. Pulping

[0070] Weigh the soaked lathyrus seeds and record it as m 2 , then the amount of water absorbed by 500g lathyrus seeds in a 6h time period is m 2 -m 1 . Crush the lathyrus seeds, separate the residue to obtain a slurry, let stand for 3 hours to settle the starch and crude fiber in the slurry, and keep the supernatant for later use. All the separated seed residues can be used as feed or organic fertilizer to make full use of useful resources.

[0071] 3. Coagulation and filtration

[0072] Take 3L of the above supernatant and heat it to near boiling, then add 7.5g CaSO 4 and 7.5...

Embodiment 1-2

[0088] Example 1-2: Extraction and purification of Panax notoginseng

[0089] 1. Soak

[0090] Select the full and undamaged pig’s dung bean seeds, and accurately weigh 500g (m 1 ), first scrub with tap water to remove dust and other impurities on the surface of the seeds; then wash three times with deionized water in the same way, and soak in 1L of deionized water for 6h.

[0091] 2. Pulping

[0092] Weigh the soaked pig's dung bean seeds and record it as m 2 , then the amount of water absorbed by 500g of pig's dung bean seeds in a 6h time period is m 2 -m 1 . Grind the seeds of the pig's dung bean, separate the residue to obtain a slurry, let it stand for 3 hours, so that the starch and crude fiber in the slurry can settle, and keep the supernatant for later use. All the separated seed residues can be used as feed or organic fertilizer to make full use of useful resources.

[0093] 3. Coagulation and filtration

[0094] Take 3L of the above supernatant and heat to 80...

Embodiment 1-3

[0099] Example 1-3: Extraction and purification of Panax notoginseng

[0100] 1. Soak

[0101] Select acacia bean seeds with full grains and no damage, and accurately weigh 500g (m 1 ), first scrub with tap water to remove dust and other impurities on the surface of the seeds; then wash three times with deionized water in the same way, and soak in 1L of deionized water for 6h.

[0102] 2. Pulping

[0103] Weigh the soaked acacia bean seeds and record it as m 2 , then the amount of water absorbed by 500g acacia bean seeds in a 6h time period is m 2 -m 1 . Crush the acacia bean seeds, separate the residue to obtain a slurry, let stand for 3 hours, so that the starch and crude fiber in the slurry settle, and keep the supernatant for later use. All the separated seed residues can be used as feed or organic fertilizer to make full use of useful resources.

[0104] 3. Coagulation and filtration

[0105] Take 3L of the above supernatant and heat to 90°C, then add 15g MgCl 2 ...

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Abstract

The invention relates to a method for separating and purifying dencichine from legume plants. Specifically, the method comprises the following steps: preparing a preliminarily purified dencichine-containing extracting solution from inorganic salt, then adjusting the pH value, carrying out exchange adsorption by using cationic resin, carrying out elution separation by using deionized water, carrying out reduced pressure evaporation and concentration on the eluent, and carrying out spray drying to obtain white powder. The white powder is identified as dencichine through liquid chromatography, infrared spectroscopy and nuclear magnetic resonance spectroscopy, and has an excellent hemostatic effect. The extraction method is simple to operate, safe and environment-friendly.

Description

technical field [0001] The invention belongs to a process or method for purifying active ingredients in the field of medicine, in particular to a process for extracting notoginseng with medicinal value from bean plants containing notoginseng. Background technique [0002] Panax notoginseng is a hemostatic active ingredient isolated from Panax notoginseng by Tzoo Kosuge in Japan, and it is named Dencichine [4] , and further confirmed that the hemostatic effect of panax notoginseng is better than that of tranexamic acid [5] . Zhao Guoqiang and others [6] It was found that notoginseng and its enantiomer β-N-oxalyl-D-α, β-diaminopropionic acid can significantly increase the number of platelets. [0003] [0004] Liu Hezhi [7] , Zheng Lu [8] , Zhang Yuping, etc. [9] The hemostatic effect and hemostatic mechanism of notoginseng were studied. Zheng Yinan and others [10] It was found that notoginseng also has the effect of anti-lipolysis and promoting fat synthesis. On t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C231/24C07C233/56B01J39/18
Inventor 杨玲娟焦成瑾赵菲佚张小寒徐全乐蒋景龙成伟
Owner TIANSHUI NORMAL UNIV
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