Mifepristone capsule and preparation method thereof
A mifepristone and capsule technology, which is applied in the field of mifepristone capsules and its preparation, can solve the problems of increasing stomach burden, influence on drug absorption, reducing availability, etc., so as to improve bioavailability and reduce nausea and vomiting. , the effect of increasing solubility
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Embodiment 1
[0061] A preparation method of mifepristone capsules, comprising the following steps:
[0062] N1: Grind mifepristone to a particle size of more than 90% and less than 10 μm, then mix 2.5 g of pulverized mifepristone with 15 g of melted solubilizer, mix evenly, cool and solidify, and then pulverize through a 40-mesh sieve to obtain Mifepristone mixtures containing solubilizers;
[0063] N2 Mix the mifepristone mixture containing the solubilizer obtained in the step N1 with 15g xanthan gum, 10g citric acid, and 57.5g lactose to obtain the contents of the capsule;
[0064] N3 filling 1 g of the capsule contents obtained in step N2 into enteric-coated empty capsules to obtain mifepristone capsules.
[0065] The solubilizer is polyoxyethylene sorbitan monolaurate.
Embodiment 2
[0067] A preparation method of mifepristone capsules, comprising the following steps:
[0068] N1: Grind mifepristone to a particle size of more than 90% and less than 10 μm, then mix 2.5 g of pulverized mifepristone with 15 g of melted solubilizer, mix evenly, cool and solidify, and then pulverize through a 40-mesh sieve to obtain Mifepristone mixtures containing solubilizers;
[0069] N2 Mix the mifepristone mixture containing the solubilizer obtained in the step N1 with 15g xanthan gum, 10g citric acid, and 57.5g lactose to obtain the contents of the capsule;
[0070] N3 filling 1 g of the capsule contents obtained in step N2 into enteric-coated empty capsules to obtain mifepristone capsules.
[0071] The solubilizer is multi-branched polyether.
[0072] The preparation method of described multi-branched polyether comprises the following steps:
[0073] S1 Mix 10g of diphenolic propane and 15g of tetraethylenepentamine, heat to 100°C to completely dissolve the diphenolic...
Embodiment 3
[0076] A preparation method of mifepristone capsules, comprising the following steps:
[0077] N1: Grind mifepristone to a particle size of more than 90% and less than 10 μm, then mix 2.5 g of pulverized mifepristone with 15 g of melted solubilizer, mix evenly, cool and solidify, and then pulverize through a 40-mesh sieve to obtain Mifepristone mixtures containing solubilizers;
[0078] N2 Mix the mifepristone mixture containing the solubilizer obtained in the step N1 with 15g xanthan gum, 10g citric acid, and 57.5g lactose to obtain the contents of the capsule;
[0079] N3 filling 1 g of the capsule contents obtained in step N2 into enteric-coated empty capsules to obtain mifepristone capsules.
[0080] The solubilizer is gelatin sodium oleate.
[0081] The preparation method of described gelatin sodium oleate, comprises the following steps:
[0082] M1 Dissolve 6g of sodium oleate in 60mL of water, heat to 70°C, stir for 10min, then add 0.3g of 1-ethyl-(3-dimethylaminopro...
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