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Application of pyrrolopyrimidine compound

A compound and application technology, applied in the field of pyrrolopyrimidine compounds, can solve life-threatening problems and achieve good preventive or therapeutic effects

Pending Publication Date: 2022-05-06
GUANGZHOU JOYO PHARMATECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, because it acts on the upstream target of the signal, it can cause a variety of non-specific reactions, including hyperlipidemia, severe infection, malignant tumor and pulmonary embolism, some of which can be life-threatening, and its toxicity is proportional to the dose

Method used

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  • Application of pyrrolopyrimidine compound
  • Application of pyrrolopyrimidine compound
  • Application of pyrrolopyrimidine compound

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] 1. Experimental animals

[0048] Animal species and strain: C57BL / 6 mice; female, weighing about 18-22g, 6-8 weeks old; purchased from Beijing Weitong Lihua Experimental Animal Technology Co., Ltd.;

[0049] Table 1 Animal grouping and administration method

[0050]

[0051]

[0052] a: The vehicle is 0.5% (w / v) hydroxypropylmethylcellulose (HPMC E5), 0.5% (w / v) polyvinylpyrrolidone (PVP K30) and 0.2% (w / v) sodium lauryl sulfate (SDS) mixed aqueous solution;

[0053] b: The vehicle is physiological saline.

[0054] The mice were randomly divided into normal control group (G1), model control group (G2), compound I group (G3), positive drug cyclosporine A group (G4), tofacitinib group (G5), compound I group (G6) and compound I group (G7), animal grouping and administration methods are shown in Table 1 for details. Model control group (G2) and model administration group animals (G3-G7) were given drinking water containing 2% DSS (dextran sodium sulfate) continuou...

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Abstract

The invention discloses an application of a pyrrolopyrimidine compound. The structure of the pyrrolopyrimidine compound is shown as a formula I, and the pyrrolopyrimidine compound can be used for preparing drugs for treating and / or preventing inflammatory bowel diseases.

Description

technical field [0001] The present invention relates to the use of a pyrrolopyrimidine compound. Background technique [0002] Inflammatory bowel disease (Inflammatory Bowel Disease, IBD) is a chronic intestinal inflammatory disease. The composition and structure of intestinal flora in IBD patients have obvious changes, which means intestinal flora dysbiosis. Intestinal barrier function plays an important regulatory role in maintaining the homeostasis of human intestinal function. Studies have shown that there is impaired intestinal barrier function and increased intestinal permeability in IBD. The dysbiosis of intestinal flora leads to the impairment of intestinal barrier function, thereby destroying the normal intestinal homeostasis function of the human body and aggravating the progression of IBD. [0003] Inflammatory bowel disease mainly includes ulcerative colitis (Ulcerative Colitis, UC) and Crohn's disease (CrohnDisease, CD), the disease is closely related to autoi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/519A61P1/00A61P1/04
CPCA61K31/519A61P1/00A61P1/04
Inventor 李永国陈小宁
Owner GUANGZHOU JOYO PHARMATECH CO LTD
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