Preparation method of rhizoma polygonati-herba houttuyniae eye drops

A technology of Houttuynia cordata and eye drops, which is applied in the direction of pharmaceutical formulations, essential oils/fragrances, medical preparations containing active ingredients, etc., which can solve the problems of prolonging the shelf life of eye drops and eye damage, and achieve good product quality and preparation The effect of low ingredients and simple process steps

Pending Publication Date: 2022-05-10
苏州眼雾医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] And existing eye drops, are in the majority with Western medicine composition, and most contain antiseptic composition simultaneously, these compositions also can cause damage to eyes while prolonging the shelf-life of eye drop.

Method used

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  • Preparation method of rhizoma polygonati-herba houttuyniae eye drops
  • Preparation method of rhizoma polygonati-herba houttuyniae eye drops

Examples

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Comparison scheme
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Embodiment 1

[0033] This embodiment provides a method for preparing Polygonatum-Houttuynia Eye Drops. The method comprises the following steps: adding 500ml of Polygonatum polysaccharide solution to 8.0g of sodium chloride, then adding 800ml of Houttuynia aromatic water, and distilling Make up to 500mL, then adjust the pH to 7.0 with 10% sodium hydroxide, mix well, pass through a 0.45μm aqueous microporous filter membrane, sterilize at 105°C for 30min, and aseptically dispense into sterilized 8mL eye drops bottles , to obtain the described Polygonatum-Houttuynia eye drops.

[0034] A kind of Polygonatum-Houttuynia eye drops preparation method according to the specific embodiment of the present invention, the preparation method of described Polygonatum polysaccharide solution is as follows:

[0035] (1) Take 20g of polygonatum polysaccharide granules and pour them into 100mL hot water at a constant temperature of 60°C, stir until the granules are completely dissolved, cool to room temperatu...

Embodiment 2

[0039] The present embodiment provides a method for preparing Polygonatum-Houttuynia eye drops. The method comprises the following steps: adding 8.5 g of sodium chloride to 500 ml of Polygonatum polysaccharide solution, then adding 400 ml of Houttuynia aromatic water, and using distilled water to Set the volume to 1000mL, then adjust the pH to 7.0 with 10% sodium hydroxide, mix well, pass through a 0.45μm aqueous microporous filter membrane, sterilize at 105°C for 30min, and aseptically dispense into sterilized 8mL eye drops bottles In the process, the Polygonatum-Houttuynia eye drops are obtained.

[0040]A kind of Polygonatum-Houttuynia eye drops preparation method according to the specific embodiment of the present invention, the preparation method of described Polygonatum polysaccharide solution is as follows:

[0041] (1) Take 30g of polygonatum polysaccharide granules and pour them into 100mL hot water at a constant temperature of 100°C, stir until the granules are compl...

Embodiment 3

[0045] The present embodiment provides a method for preparing Polygonatum-Houttuynia eye drops. The method comprises the following steps: adding 8.0 g of sodium chloride to 400 ml of Polygonatum polysaccharide solution, then adding 500 ml of Houttuynia aromatic water, and using distilled water to Set the volume to 1000mL, then adjust the pH to 7.0 with 10% sodium hydroxide, mix well, pass through a 0.45μm aqueous microporous filter membrane, sterilize at 105°C for 30min, and aseptically dispense into sterilized 8mL eye drops bottles In the process, the Polygonatum-Houttuynia eye drops are obtained.

[0046] A kind of Polygonatum-Houttuynia eye drops preparation method according to the specific embodiment of the present invention, the preparation method of described Polygonatum polysaccharide solution is as follows:

[0047] (1) Take 20g of polygonatum polysaccharide granules and pour them into 100mL hot water at a constant temperature of 90°C, stir until the granules are compl...

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Abstract

The invention relates to the technical field of medical external eye drops, in particular to a preparation method of rhizoma polygonati-herba houttuyniae eye drops, which comprises the following steps: adding sodium chloride into a rhizoma polygonati polysaccharide solution, then adding herba houttuyniae aromatic water, fixing the volume by using distilled water, then adjusting the pH value to 7.0, uniformly mixing, passing through a microfiltration membrane, and sterilizing to obtain the rhizoma polygonati-herba houttuyniae eye drops. Compared with the prior art, the rhizoma polygonati-herba houttuyniae eye drops prepared by the method disclosed by the invention have the following beneficial effects that the rhizoma polygonati-herba houttuyniae eye drops prepared by the method disclosed by the invention take the rhizoma polygonati polysaccharide solution and the herba houttuyniae aromatic water as main raw materials, do not contain Western medicine components and preservative components, are purer in formula, stable in contents of rhizoma polygonati polysaccharide and methyl n-nonanone, and free of toxic and side effects. In the prepared rhizoma polygonati-herba houttuyniae eye drops, the content of rhizoma polygonati polysaccharide is about 0.8%, the content of methyl nonanone is about 4 [mu] g/mL, and the rhizoma polygonati-herba houttuyniae eye drops have the effects of treating xerophthalmia and relieving asthenopia.

Description

technical field [0001] The invention belongs to the technical field of medical eye drops for external use, and in particular relates to a preparation method of Polygonatum-Houttuynia eye drops. Background technique [0002] Eye drops are one of the most commonly used pharmaceutical dosage forms for eye diseases. For many eye diseases, eye drops have direct and quick therapeutic effects. As people's lifestyles and working conditions change, people spend more and more time using their eyes, and they are prone to visual fatigue and dry eye syndrome. [0003] And existing eye drops, are in the majority with Western medicine composition, and majority contains antiseptic composition simultaneously, and these compositions also can cause damage to eyes when prolonging the shelf-life of eye drop. [0004] In view of this, apply for this patent. Contents of the invention [0005] In order to overcome the shortcomings of the existing technology, this patent uses Polygonatum polysac...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K36/78A61K31/715A61K33/14A61P27/02C08B37/00C11B9/02
CPCA61K9/08A61K9/0048A61K36/78A61K31/715A61K33/14A61P27/02C08B37/003C11B9/027C11B9/02A61K2300/00
Inventor 薛晓丽赵思远
Owner 苏州眼雾医疗科技有限公司
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