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Application of miRNA molecule as early lung cancer detection marker

A molecular marker and lung cancer technology, applied in the field of biomedicine, can solve the problems of low sensitivity and specificity of cancer cells and unsatisfactory lung cancer, and achieve high diagnostic value, easy detection and quantification, good specificity and sensitivity sexual effect

Pending Publication Date: 2022-05-10
BEIJING CHEST HOSPITAL CAPITAL MEDICAL UNIV +1
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  • Description
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Problems solved by technology

Although a variety of blood tumor markers have been widely used, they are still unsatisfactory in the early diagnosis of lung cancer due to their relatively low sensitivity and specificity in detecting cancer cells, so new potential biomarkers must be explored. Tumor markers to improve screening and diagnosis

Method used

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  • Application of miRNA molecule as early lung cancer detection marker
  • Application of miRNA molecule as early lung cancer detection marker
  • Application of miRNA molecule as early lung cancer detection marker

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Embodiment 1

[0041] 1. Research object

[0042] The research subjects were collected from the specimen bank of Beijing Chest Hospital, and all came from an epidemiological screening study carried out in Beijing through low-dose CT examination from September 2016 to September 2019. Plasma samples included 24 new cases as the case group and 48 healthy people without disease who were screened at the same time and matched 1:2 according to gender and age ± 5 years as the cancer-free healthy control group.

[0043] Inclusion criteria: ①Clearly diagnosed by histopathology, and the diagnostic criteria refer to the Chinese guidelines for the diagnosis and treatment of primary lung cancer (2015 edition); ②Complete relevant clinical data, including demographic characteristics, such as age, gender, smoking status, occupational exposure, and pathological diagnosis ; ③ had not received radiotherapy, chemotherapy, immunotherapy and other medical treatment and surgical treatment before hospitalization; ④ ...

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Abstract

The invention provides application of a miRNA molecular marker in preparation of an early lung cancer detection reagent, and relates to the technical field of biomedicine. And the miRNA molecular marker comprises miR-99a-5p (micro Ribonucleic Acid). The invention researches the relationship between the miRNA expression level in plasma before the incidence of a new lung cancer case (early lung cancer) and the incidence of lung cancer, and finds that miR-99a-5p has strong identification and prediction capabilities for the early diagnosis of lung cancer, and can be used as a marker for the early screening and / or diagnosis of lung cancer.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to the application of miRNA molecular markers in the preparation of early lung cancer detection reagents. Background technique [0002] Early screening and diagnosis is one of the key means to reduce the mortality of lung cancer, and the sensitivity of early screening is an important aspect to judge the screening effect. Low-dose spiral computed tomography (low-dose spiral CT, LDCT) is one of the commonly used screening methods for lung cancer. Potential radiation-induced carcinogenesis and increased medical and health costs, and there are certain requirements for detection instruments, so the clinical application is limited. Although other commonly used imaging examinations have played an important role in lung cancer screening, there are still problems such as missed diagnosis or overdiagnosis, and it is difficult to be an effective method for early screening of lung cancer. ...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6886
CPCC12Q1/6886C12Q2600/158C12Q2600/178
Inventor 刘洋林婷婷王赛赛宋治鹏董静吕霞丽潘丽萍张宗德
Owner BEIJING CHEST HOSPITAL CAPITAL MEDICAL UNIV
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