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Method for extracting bakuchiol from elm roots and purifying bakuchiol and application of bakuchiol in cosmetics

A technology of bakuchiol and cosmetics, which is applied in the direction of cosmetics, cosmetic preparations, chemical instruments and methods, and can solve problems such as inflammation, skin sensitivity, and allergies

Pending Publication Date: 2022-05-13
江苏巴帝恩生物科技有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are a lot of chemical additives in most cosmetics on the market, which can easily cause skin sensitivity and even inflammation. Sensitive skin is very prone to allergies when using ordinary cosmetics

Method used

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  • Method for extracting bakuchiol from elm roots and purifying bakuchiol and application of bakuchiol in cosmetics
  • Method for extracting bakuchiol from elm roots and purifying bakuchiol and application of bakuchiol in cosmetics
  • Method for extracting bakuchiol from elm roots and purifying bakuchiol and application of bakuchiol in cosmetics

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] 001, select the spring elm root raw material, clean it with pure water, dry it, and crush it for later use;

[0029] 002, the crushed spring elm root was extracted with 5 times 80% ethanol at 70°C for 4 hours, cooled to room temperature, filtered with 1um filter paper, and the filtrate was collected.

[0030] 003, concentrate the leach filtrate under reduced pressure at 75°C to 1 / 7 of the filtrate, recover ethanol at the same time, and collect the concentrated residue;

[0031] 004, extract the concentrated residue with 1.5 times of n-butanol, collect the n-butanol part, and concentrate under reduced pressure at 60°C until there is no n-butanol;

[0032] 005, the n-butanol fraction residue was separated by silica gel column chromatography, and the fraction residue was separated into four subgroups I, II, III, and IV using a development system of chloroform / methanol / water=6:4:1 Minute;

[0033] 006, using a mixture of ethyl acetate: hexane at a ratio of 1:2 as the elue...

Embodiment 2

[0035] 001, select the spring elm root raw material, clean it with pure water, dry it, and crush it for later use;

[0036] 002, the crushed spring elm root was extracted with 3 times 70% ethanol at 60°C for 6 hours, cooled to room temperature, filtered with 1um filter paper, and the filtrate was collected.

[0037] 003, concentrating the leach filtrate under reduced pressure at 75°C to 1 / 10 of the filtrate, while recovering ethanol, and collecting the concentrated residue;

[0038] 004, extract the concentrated residue with 2 times of n-butanol, collect the n-butanol part, and concentrate under reduced pressure at 65°C until there is no n-butanol;

[0039] 005, the n-butanol fraction residue was separated by silica gel column chromatography, and the fraction residue was separated into four subgroups I, II, III, and IV by using a development system of chloroform / methanol / water=5.5:4.5:1 Minute;

[0040] 006, using a mixture of ethyl acetate: hexane at a ratio of 1:1.5 as the...

Embodiment 3

[0042] 001, select the spring elm root raw material, clean it with pure water, dry it, and crush it for later use;

[0043] 002, the crushed spring elm root was soaked and extracted with 3 times 60% ethanol at 75°C for 3 hours. After the extraction was completed, the temperature was cooled to room temperature, filtered with 1um filter paper, and the filtrate was collected.

[0044] 003, concentrating the leach filtrate under reduced pressure at 75°C to 1 / 10 of the filtrate, while recovering ethanol, and collecting the concentrated residue;

[0045] 004, extract the concentrated residue with 2 times of n-butanol, collect the n-butanol part, and concentrate under reduced pressure at 65°C until there is no n-butanol;

[0046] 005, the n-butanol fraction residue was separated by silica gel column chromatography, and the fraction residue was separated into four subgroups I, II, III, and IV by using a developing system of chloroform / methanol / water=5.5:5:1 Minute;

[0047] 006, usi...

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Abstract

The invention provides a method for extracting bakuchiol from spring elm roots and purifying bakuchiol and application of bakuchiol in cosmetics, and belongs to the technical field of cosmetics. Dry spring elm root plant materials are smashed and then extracted with ethyl alcohol, then vacuum concentration is conducted, extraction is conducted with n-butyl alcohol, the n-butyl alcohol part is collected and concentrated, and bakuchiol is obtained; the method comprises the following steps: carrying out silica gel column chromatography on n-butyl alcohol fraction residues, separating the n-butyl alcohol fraction residues into four sub-components I-IV, further purifying the sub-component IV on silica gel, collecting a chromatographic solution, and concentrating to obtain a finished product. By means of the method, high-purity bakuchiol can be obtained, the bakuchiol is excellent in anti-inflammatory effect, and the good anti-inflammatory effect is achieved when the bakuchiol is applied to cosmetics.

Description

technical field [0001] The invention relates to the technical field of cosmetics, in particular to a method for extracting and purifying bakuchiol from elm elm root and its application in cosmetics. Background technique [0002] Spring elm (scientific name: Ulmus davidiana Planch. var. japonica (Rehd.) Nakai) is a plant of the genus Ulmus in the family Ulmaceae. Deciduous trees or shrubs, up to 15 m tall, 30 cm in diameter at breast height; bark darker, longitudinally split into irregular strips, young branches densely or sparsely pilose, current year branches glabrous or somewhat hairy. Distributed in North Korea, Russia, Japan and China; in China, it is distributed in Heilongjiang, Jilin, Liaoning, Inner Mongolia, Hebei, Shandong, Zhejiang, Shanxi, Anhui, Henan, Hubei, Shaanxi, Gansu and Qinghai. It grows on river banks, streamsides, valleys, foothills and well-drained alluvial lands and hillsides. [0003] The bark of the spring elm is used as a traditional Korean medic...

Claims

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Application Information

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IPC IPC(8): C07C37/72C07C37/82C07C39/19A61K8/34A61P37/08A61Q19/00
CPCC07C37/004C07C37/685C07C37/72C07C37/82A61K8/347A61Q19/005A61P37/08A61K2800/782A61K2800/805C07C39/19
Inventor 陈秀玉詹柱刘晓磊丁冲冲钱峰郑海兵赵治勇金荣熙周秋娜朱荣儿金延埈
Owner 江苏巴帝恩生物科技有限公司
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