Magneto-optical double-field contrast agent as well as preparation method and application thereof

A contrast agent and magneto-optic technology, applied in the fields of material science and biomedical technology, can solve the problems of white light endoscopy, such as the unsatisfactory effect of white light endoscopy, the inability to display the morphological characteristics of the upper gastrointestinal tract, and the missed diagnosis of adenoma, and achieve excellent luminescence properties, enhanced diagnostic performance, and improved diagnostic sensitivity

Pending Publication Date: 2022-05-17
SHANDONG NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] In upper gastrointestinal radiography, traditional barium meal radiography cannot reveal the specific morphological characteristics of the upper gastrointestinal tract; lower gastrointestinal lesions mainly rely on white light endoscopy, combined with abnormal intestinal mucosal pathological biopsy to diagnose polyps, tumors, inflammation or vascular malformations etc., but the effect of white light endoscopy is far from ideal. It is reported that standard electronic colonoscopy even has a missed diagnosis rate of up to 40% of adenomas.

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  • Magneto-optical double-field contrast agent as well as preparation method and application thereof
  • Magneto-optical double-field contrast agent as well as preparation method and application thereof
  • Magneto-optical double-field contrast agent as well as preparation method and application thereof

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preparation example Construction

[0042] In one embodiment of the present invention, a method for preparing a magneto-optical dual-field contrast agent includes:

[0043] (1), preparation of superparamagnetic ferric oxide: to FeCl 3 , FeCl 2 Quickly add ammonia water to the mixed solution, continue the reaction and cool to room temperature, and obtain superparamagnetic ferroferric oxide after cleaning;

[0044] (2), preparation of mesoporous silica cladding layer: cetyltrimethylammonium bromide, absolute ethanol, deionized water are stirred and mixed, and ammonia solution and superparamagnetic iron tetroxide are added simultaneously, After stirring, wait for a period of time and continue to add tetraethyl orthosilicate dropwise, heat the mixture in a water bath for the first time to obtain a precipitate; centrifuge the precipitate to obtain a secondary precipitate, wash the secondary precipitate, and pour out the supernatant Then add NH 4 NO 3 , ethanol solution and stirred, the mixed solution was heated i...

Embodiment 1

[0061] (1) Preparation of superparamagnetic ferric oxide nanoparticles:

[0062] First, take 20 mL of Fe with a concentration of 0.2 mol / L 2 (SO 4 ) 3 solution and Fe at a concentration of 0.1mol / L 2 (SO 4 ) 2 The solution is mixed, and the mixed solution is in N 2 Mechanical stirring was carried out under protection for 10 min. Then, 7.5 mL (28% wt) of ammonia water was injected into the mixture rapidly at one time, and the reaction was continued for 25 min and then cooled to room temperature. Then wash with 0.02mol / L sodium chloride solution and double distilled water respectively. Put a test magnet in the mixture, wait for the particles to settle, pour out the supernatant, and dry at 60° C. to finally obtain 0.39 g of superparamagnetic ferric oxide nanoparticles.

[0063] (2) Preparation of mesoporous silica coating:

[0064] Add 75mg of cetyltrimethylammonium bromide (CTAB), 15mL of absolute ethanol, and 25mL of deionized water to the beaker in turn, stir and mix ...

Embodiment 2

[0070] (1) Preparation of superparamagnetic ferric oxide nanoparticles:

[0071] First, take 20 mL of Fe(NO with a concentration of 0.2 mol / L 3 ) 3 solution and a concentration of 0.1mol / L Fe(NO 3 ) 2 The solution is mixed, and the mixed solution is in N 2 Mechanical stirring was carried out under protection for 10 min. Then, 7.5 mL (28% wt) of ammonia water was injected into the mixture rapidly at one time, and the reaction was continued for 25 min and then cooled to room temperature. Then wash with 0.02mol / L sodium chloride solution and double distilled water respectively. Put a test magnet in the mixture, wait for the particles to settle, pour out the supernatant, and dry at 60° C. to finally obtain 0.39 g of superparamagnetic ferric oxide nanoparticles.

[0072] (2) Preparation of mesoporous silica coating:

[0073] Add 75mg of cetyltrimethylammonium bromide (CTAB), 15mL of absolute ethanol, and 25mL of deionized water to the beaker in turn, stir and mix thoroughly, a...

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Abstract

The invention relates to the technical field of material science and biological medicine science and technology, in particular to a magneto-optical double-field contrast agent and a preparation method and application thereof, and the structure of the contrast agent is a superparamagnetic ferroferric oxide structure wrapped by hyaluronic acid and mesoporous silica; meanwhile, the mesoporous silica coated superparamagnetic ferriferrous oxide structure is also filled with rare earth elements. On the basis of the magneto-optical double-field contrast agent and controllable and accurate positioning magnetic field contrast, the contrast agent prepared by doping a trace amount of low-toxicity rare earth luminescent material bait further reduces the biotoxicity, realizes optical coherence imaging and magnetic field contrast double-field imaging, enhances the developing effect, and has a wide application prospect. The stenosis degree of the anatomical structure of the coronary artery lumen can be accurately judged, and the pathological and physiological change degree of the coronary artery lumen can be predicted.

Description

technical field [0001] The invention relates to the technical fields of material science and biomedicine technology, in particular to a magneto-optical double-field contrast agent and its preparation method and application. Background technique [0002] The information disclosed in this background section is only intended to increase the understanding of the general background of the present invention, and is not necessarily taken as an acknowledgment or any form of suggestion that the information constitutes the prior art already known to those skilled in the art. [0003] At present, the latest generation of intravascular angiography on the market uses optical coherent imaging technology, but due to factors such as the complex liquid environment in the blood vessel, the imaging effect and efficiency are not high, which seriously affects the application range of this technology in intravascular angiography. Coronary angiography for critical coronary artery lesions only reve...

Claims

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Application Information

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Patent Type & AuthorityApplications(China)
IPC IPC(8): A61K49/12A61K49/00
CPCA61K49/126A61K49/0019A61K49/0002
Inventor寇慧玲程晨桂维玲周玉翔董思雨姚桂翔安泰宇
OwnerSHANDONG NORMAL UNIV