Acoustic particle capturing and trajectory control method based on magnetofluid reconstruction
A magnetic fluid and particle technology, applied in chemical instruments and methods, biochemical equipment and methods, stress-stimulated microbial growth methods, etc., to achieve the effects of simple equipment, strong controllability, and easy operation
Active Publication Date: 2022-05-24
ZHEJIANG UNIV
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Problems solved by technology
[0005]
In order to solve the problems existing in the effective capture of particles by conventional magnetic tweezers and acoustic tweezers and the control of complex trajectories, the invention proposes An Acoustic Particle Trapping and Trajectory Manipulation Method Based on Magnetic Fluid Reconstruction
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[0036] The present invention is further described below in conjunction with the accompanying drawings and embodiments, but embodiments of the present invention are not limited thereto.
[0037] as Figure 1 and Figure 2As shown, the apparatus used in a particular embodiment of the present invention comprises a magnetic fluid 2, chamber 3 and piezoelectric ceramic sheet 7; chamber 3 at one end opens a chamber inlet 1, the other end opens a chamber outlet; the lower chamber 3 is arranged with a magnetic field 4, the chamber 3 is filled with magnetic fluid 2 and particles 6, the magnetic fluid 2 is controlled by the magnetic field 4 to produce a surface magnetic column microstructure 5, chamber 3 is provided with piezoelectric ceramic sheets 7 on both sides along the flow direction.
[0038] The magnetic field 4 is generated by a permanent magnet of a particular shape disposed at the bottom of the chamber 3.
[0039] The embodiment embodiment process comprises the following steps:
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The invention discloses an acoustic particle capturing and trajectory control method based on magnetofluid reconstruction. Magnetic fluid is injected into the cavity and forms a surface micro magnetic column structure under the action of a magnetic field; surface micro-magnetic column structures with different geometrical morphologies are reconstructed by accurately controlling the shape of a magnetic field and the magnetic field intensity; micro-particle turbid liquid is injected into the cavity, ultrasonic waves are excited in the cavity, and at the moment, sound field local constraining force is generated around the micro-magnetic column structure to capture nearby micro-particles; the distribution characteristics of the particles are accurately adjusted by changing the shape of the magnetic field, and the geometrical morphology characteristics and positions of the surface micro-magnetic columns are changed by changing the position and strength of the magnetic field. The device can realize non-contact accurate capture and complex track transmission of particles, has the characteristics of simplicity and convenience in operation, high controllability, simple equipment, high precision, non-contact and the like, and can be used for synchronously capturing and controlling a single particle and multiple particles.
Description
Technical field [0001] The present invention relates to an acoustic particle capture and manipulation method, in particular to an acoustic particle capture and trajectory manipulation method based on magnetic fluid reconstruction. Background [0002] Precise manipulation of microscale objects (such as biological cells, polymer particles, and multicellular biological tissues) has become a key technology in biomedical analysis, and the development of this technology will greatly facilitate a number of important areas including cell characterization, accurate drug delivery, and precise cell assembly. The current microfluidics, which focuses on micron-scale controlled fluids, has led to the birth of a series of biomedical and other analytical methods, and has realized a variety of microparticle operation methods, including magnetic tweezers, optical tweezers, dielectric electrophoresis, and acoustic tweezers. Among them, the operation efficiency of magnetic tweezers is greatly limite...
Claims
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Login to View More IPC IPC(8): B01J19/08B01J19/10C12M1/42C12N13/00
CPCB01J19/087B01J19/10C12M47/04C12N13/00
Inventor 汪延成盘何旻翁婉玉梅德庆许诚瑶陶凯
Owner ZHEJIANG UNIV