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Compound pholcodine oral solution and preparation method thereof

A technology for oral administration and oral solution of phalcodine, which is applied in the fields of pharmaceutical formulation, dispersion liquid delivery, and medical preparations of non-active ingredients, etc. It can solve the problems of patients such as dizziness, drowsiness, nausea and heartburn, and achieve the purpose of slowing down adverse reactions and reducing irritation , Improve the effect of taking compliance

Pending Publication Date: 2022-05-27
南昌立健药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, in the prior art, the compound phalcodine oral solution is likely to cause dizziness and drowsiness in patients, stimulate the gastrointestinal tract and cause nausea and heartburn and other uncomfortable symptoms.

Method used

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  • Compound pholcodine oral solution and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] A compound phloxidine oral solution, wherein the pharmaceutical component ratio per milliliter of the compound phlebine oral solution is: phloxidine 1 mg, triprolidine hydrochloride 0.12 mg, pseudoephedrine hydrochloride 3.0 mg, guaiac Glycerol ether 10.0mg, Scallion fluid extract 0.001mL, Polygala Radix extract 0.001mL.

[0021] The preparation method of above-mentioned compound pholcodine oral solution is:

[0022] (1) Pseudoephedrine hydrochloride is added to the purified water of 3 times of mass, after stirring, add the mixed powder of β-cyclodextrin of the same quality as pseudoephedrine hydrochloride: the mass ratio of γ-cyclodextrin is 1:2, homogeneously dispersed Then, add the menthol of pseudoephedrine hydrochloride quality 2%: the mixture of edible alcohol 1:1, obtain sol after homogenization;

[0023] (2) Add other medicinal components according to the proportion, and after the dissolution is completed, add step (1) to prepare a sol, disperse, and add citric...

Embodiment 2

[0030] A compound phloxidine oral solution, wherein the pharmaceutical component ratio per milliliter of the compound phlebine oral solution is: phloxidine 1 mg, triprolidine hydrochloride 0.12 mg, pseudoephedrine hydrochloride 3.0 mg, guaiac Glycerol ether 10.0mg, Scallion fluid extract 0.001mL, Polygala Radix extract 0.001mL.

[0031] The preparation method of above-mentioned compound pholcodine oral solution is:

[0032] (1) Pseudoephedrine hydrochloride is added to the purified water of 4 times of mass, after stirring, adding the β-cyclodextrin of the same quality as pseudoephedrine hydrochloride: the mixed powder of γ-cyclodextrin mass ratio of 1:3, uniformly dispersed Then, add the menthol of pseudoephedrine hydrochloride quality 2%: the mixture of edible alcohol 1:1, obtain sol after homogenization;

[0033] (2) adding other medicinal components according to the proportion, after dissolving, adding the step (1) to obtain a sol, dispersing, adding citric acid to adjust ...

Embodiment 3

[0040] A compound phloxidine oral solution, wherein the pharmaceutical component ratio per milliliter of the compound phlebine oral solution is: phloxidine 1 mg, triprolidine hydrochloride 0.12 mg, pseudoephedrine hydrochloride 3.0 mg, guaiac Glycerol ether 10.0mg, Scallion fluid extract 0.001mL, Polygala Radix extract 0.001mL.

[0041] The preparation method of above-mentioned compound pholcodine oral solution is:

[0042] (1) Pseudoephedrine hydrochloride is added to the purified water of 5 times of mass, after stirring, add the mixed powder of β-cyclodextrin of the same quality as pseudoephedrine hydrochloride: the mass ratio of γ-cyclodextrin is 1:3, and uniformly disperse Then, add the menthol of pseudoephedrine hydrochloride quality 2%: the mixture of edible alcohol 1:1, obtain sol after homogenization;

[0043] (2) adding other medicinal components according to the proportion, after dissolving, adding the step (1) to obtain a sol, dispersing, adding citric acid to adju...

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Abstract

The invention discloses a compound pholcodine oral solution and a preparation method thereof. According to the preparation method, pseudoephedrine hydrochloride can be effectively embedded, and the adverse reaction of dizziness and sleepiness of the compound pholcodine oral solution is relieved. The polygala tenuifolia fluid extract prepared by the invention is beneficial to reducing the stimulation of the compound pholcodine oral solution to gastrointestinal tracts and improving the taking compliance of the compound pholcodine oral solution.

Description

technical field [0001] The invention relates to a compound phloxidine oral solution and a preparation method thereof. Background technique [0002] The main components of Compound Phorcodine Oral Solution contain Phorcodine, triprolidine hydrochloride, pseudoephedrine hydrochloride and guaiacol glyceryl ether, supplemented with a certain amount of sea onion extract and polygala extract, mainly used for Common cold, influenza, cough caused by throat and bronchial irritation, as well as phlegm cough, dry cough, nasal congestion and sore throat in patients. Volcodine is a central antitussive; triprolidine hydrochloride is an antihistamine, which can reduce edema of the respiratory tract; pseudoephedrine hydrochloride can combat nasal mucosal congestion and eustachian tube congestion; guaiacol glycerol ether can Dilation of bronchioles reduces the viscosity of airway secretions, and has the effect of resolving phlegm; sea cucumber fluid extract has expectorant and antitussive e...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K36/896A61K47/69A61P11/00A61P31/16A61P11/04A61P11/14A61P11/02A61P29/00A61K31/5377A61K31/4439A61K31/137A61K31/09
CPCA61K9/0095A61K31/5377A61K31/4439A61K31/137A61K31/09A61K36/896A61K36/69A61K47/6951A61P11/00A61P31/16A61P11/04A61P11/14A61P11/02A61P29/00A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61K2236/53A61K2236/15A61K2300/00
Inventor 王琳琳
Owner 南昌立健药业有限公司
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