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Compound preparation prepared from amoxicillin and cimetidine and preparation method

A compound preparation, the technology of cimetidine, applied in the field of medicine, can solve problems such as troublesome application and insufficient curative effect, and achieve the effects of reducing side effects, improving curative effect, and being convenient to use

Pending Publication Date: 2022-05-31
崔天佑
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In view of the insufficient curative effect of the existing single drug and the troublesome combined application of multiple drugs, the purpose of this application is to provide a compound preparation prepared by amoxicillin and cimetidine and its preparation method

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] A compound formulation prepared from amoxicillin and cimetidine, the active ingredient of the compound formulation, amoxicillin and cimetidine weight ratio of 0.125: 0.05, the residual amount is an excipient. The preparation method comprises the following steps:

[0023] (1) Take amoxicillin API 12.5g, standby;

[0024] (2) Take 5.0g of cimetidine API and set aside;

[0025] (3) Take the appropriate amount of the required excipients suitable for the preparation and spare;

[0026] (4) Make granules according to the preparation method of pharmacy granules, so that each contains amoxicillin 125mg, cimetidine 50mg.

Embodiment 2

[0028] A compound formulation prepared by amoxicillin and cimetidine, the active ingredient of the compound formulation, amoxicillin and cimetidine weight ratio of 0.24: 0.1, the residual amount is an excipient. The preparation method comprises the following steps:

[0029] (1) Take amoxicillin API 24g, set aside

[0030] (2) Take 10g of the original drug of cimetidine and set aside

[0031] (3) Take the appropriate amount of the required excipients suitable for the preparation and spare;

[0032] (4) Make capsules according to the preparation method of pharmacy capsules, so that each capsule contains amoxicillin 240mg and cimetidine 100mg.

Embodiment 3

[0034] A compound formulation prepared by amoxicillin and cimetidine, the active ingredient of the compound formulation, amoxicillin and cimetidine weight ratio of 0.5: 0.2, the residual amount is an excipient. The preparation method comprises the following steps:

[0035] (1) Take 50g of amoxicillin API and set aside

[0036] (2) Take 20g of the original drug of cimetidine and set aside

[0037] (3) Take the appropriate amount of the required excipients suitable for the preparation and spare;

[0038] (4) According to the preparation method of pharmaceutical tablets, tablets are made, so that each tablet contains 500mg of amoxicillin and 200mg of cimetidine

[0039] Efficacy test

[0040] 1. Select the drugs prepared by Example 1, 2 and 3 and conduct clinical trials.

[0041] According to the parallel, randomized, controlled experimental design scheme, a control group is strictly set up to observe the clinical efficacy of the drugs prepared in Example 1, 2, and 3.

[0042] 2. Case...

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Abstract

The invention provides a compound preparation prepared from amoxicillin and cimetidine and a preparation method of the compound preparation, and the compound preparation comprises the following active ingredients: amoxicillin and cimetidine in a ratio of (0.125-0.5): (0.05-0.2). The active pharmaceutical ingredients amoxicillin and cimetidine are taken, then a proper amount of auxiliary materials required by the prepared preparation are taken, and the active pharmaceutical ingredients amoxicillin and cimetidine can be respectively prepared into compound preparations such as powder injections, tablets, capsules, dry suspensions or granules according to corresponding preparation preparation methods in pharmaceutics. Amoxicillin is a penicillin semi-synthetic broad-spectrum antibiotic, and has a good effect on infection of respiratory, digestive, urogenital systems, skin soft tissues and the like caused by sensitive bacteria; cimetidine is a liver drug enzyme inhibitor, and cimetidine is combined to delay the metabolism of amoxicillin and improve the blood concentration of amoxicillin, so that the antibacterial effect of amoxicillin is enhanced, and the action time is prolonged; cimetidine can also alleviate the stimulation of amoxicillin to the stomach by inhibiting gastric acid secretion, reduces the side effect, and is convenient to use.

Description

Technical field [0001] The present application relates to the field of medical technology, in particular to a compound formulation prepared by amoxicillin and cimetidine and a method of preparation. Background [0002] Amoxicillin is a penicillin semi-synthetic broad-spectrum antibiotic, which produces a bactericidal effect by inhibiting the synthesis of bacterial cell walls, and has a strong bactericidal effect. After medication, the lactam bond in the drug molecule is immediately hydrolyzed to generate peptide bonds, and the transpeptidase in the bacterium is quickly combined to inactivate it, cutting off the only way for the bacterium to rely on transpeptidase to synthesize glycopeptides to build the cell wall, and the bacteria eventually become cell wall defects, and the bacterial cells quickly become spherical and rupture and dissolve to death. It has a strong bacteriostatic and bactericidal effect on most pathogenic G+ bacteria and G-bacteria. Among them, the non-β lactamas...

Claims

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Application Information

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IPC IPC(8): A61K31/43A61K31/4164A61P31/04
CPCA61K31/43A61K31/4164A61P31/04A61K2300/00Y02A50/30
Inventor 崔天佑
Owner 崔天佑
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