Preparation method of alkyl alcohol

Abstract

The invention belongs to the field of organic synthesis, and discloses a preparation method of alkyl alcohol, which comprises the following steps: by taking a bromine compound and an epoxy compound as raw materials, under the conditions that cuprous chloride is taken as a catalyst, tetramethylethylenediamine (TMEDA) is taken as a ligand, lithium methoxide (LiOMe) is taken as alkali and magnesium powder is taken as a reducing agent, carrying out a reaction formula reaction for 12 hours in a tetrahydrofuran solvent at 0 DEG C to obtain an alkyl alcohol compound. Reagents needed by the reaction are low in price, operation is easy, a pre-prepared Grignard reagent does not need to be used, use is convenient, and the synthesis application value is high.

Description

A kind of preparation method of alkyl alcohol technical field The invention belongs to the technical field of organic synthesis, relate to a kind of method for preparing alkyl alcohol compound based on copper catalysis. Background technique [0002] Alkyl alcohols are a class of important organic structural fragments, which are widely used in industries such as medicines and materials. and alkane Alkyl alcohols are also an important class of organic synthesis intermediates, which can be converted into alkyl halides, alkyl sulfonates by simple chemical reactions Organic synthons such as esters, and participate in a variety of metal-catalyzed cross-coupling reactions for the construction of C-C bonds and C-hetero bonds. because The development of efficient, convenient and easy-to-operate synthetic methods for alkyl alcohols has always been the focus of researchers. The method of traditional synthetic alkyl alcohol generally has: (1) halogenated hydrocarbon hydrolysis r...

AI Technical Summary

Problems solved by technology

[0008] For the reaction of epoxy compounds and Grignard reagents to prepare alkyl alcohols, pre-prepared Grignard reagents need to be used, but Grignard reagents have problems such as storage, transportation, and use conditions. The technical problems that need to be solved in this patent are Avoiding the use of Grignard reagents, using copper-catalyzed reductive coupling methods, using bromide and epoxy as raw materials for ring-opening reactions to prepare alkyl alcohols

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