Diabetic rat memory dysfunction testing system based on ginkgo biloba extract

Abstract

The invention discloses a diabetic rat memory dysfunction testing system based on a ginkgo leaf extract. Comprising a surrounding module, a supporting face module fixedly connected to the interior of the surrounding module, a safety area module installed at the bottom of the surrounding module, an obstacle limiting area module slidably connected to the lower portion of the supporting face module, and an ultrasonic induction module installed on the inner wall of the surrounding module. The method comprises the following steps of: driving rats through an ultrasonic induction module inside a surrounding module by using audio disgusted by the rats as a driving factor, enabling the rats to avoid sound intervention of the ultrasonic induction module, and stopping the sound until the rats search or arrive at a safe area module through external auxiliary learning, so that the rats form learning memory; when a follow-up dysmnesia test is carried out, blood in a rat body is not influenced by temperature difference changes at the moment, actual detection data are more accurate, meanwhile, two training modes can be adopted for testing, and the testing accuracy is further improved.

Description

technical field [0001] The invention relates to the technical field of memory dysfunction testing, in particular to a memory dysfunction testing system for diabetic rats based on Ginkgo biloba extract. Background technique [0002] Ginkgo biloba extract (GBE) is a learning and memory enhancer. The main pharmacological components are total flavonoids, ginkgolides, etc. The memory impairment of diabetes is aggravated with the continuous hyperglycemia, and the learning and memory impairment and cerebral blood flow of diabetic patients are reduced. It leads to the thickening of the capillary basement membrane, resulting in stenosis of the lumen and a decrease in cerebral blood flow. Diabetic patients are often accompanied by lipid metabolism disorders, which increase blood viscosity, slow down blood circulation, and reduce blood flow to a certain extent. Cerebral blood flow, in order to study the effect of Ginkgo biloba extract (GBE) on diabetes, diabetic rats are often injected...

AI Technical Summary

Problems solved by technology

[0002] Ginkgo biloba extract (GBE) is a learning and memory function enhancer. The main pharmacological components are total flavonoids, ginkgolides, etc. The memory impairment of diabetes will aggravate with the persistence of high blood sugar, and the learning and memory impairment and cerebral blood flow of diabetic patients will decrease. related, lead to thickening of the capillary basement membrane, narrowing of the lumen, and reduction of cerebral blood flow. Diabetic patients are often accompanied by lipid metabolism disorders, which aggravate blood viscosity, slow down blood circulation, and also reduce blood flow to a certain extent. Cerebral blood flow, in order to study the impact of ginkgo biloba extract (GBE) on diabetes, often inject GBE to diabetic rats, after learning and remembering the rats, by observing the memory effect experiment of the rats, to judge the effect of GBE on diabetic memory impairment Affecting the effect, the existing morris water maze mainly uses the cylindrical chamber, and the animal finds a place to rest, forming a memory area habitually. The purpose is to reduce heat dissipation. Of course, the blood flow rate will also slow down, which will affect the blood flow. Even if the water temperature is precisely controlled to keep the water temperature consistent with that of the rats, when the rats are out of the water, if they are dried It is easy to cause temperature changes and affect the blood flow rate. If it is dried, the temperature of the rat will drop at this time, which will also easily affect the blood flow rate, and the core factors in the experiment process will continue to change.

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