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Moisture-resistant vitamin mineral tablet and moisture-resistant treatment method thereof

A technology of vitamins and minerals, applied in chemical instruments and methods, chemical/physical processes, drug combinations, etc., can solve the problems of unavoidable moisture absorption of materials, improve moisture resistance, improve moisture resistance, and improve granulation efficiency effect

Active Publication Date: 2022-06-03
HANGZHOU MINSHENG HEALTHCARE CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the coating mode is usually used to protect the solid preparation from moisture absorption, but usually only the plain tablet can be coated to achieve moisture resistance, and the moisture absorption of the intermediate link cannot be avoided.

Method used

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  • Moisture-resistant vitamin mineral tablet and moisture-resistant treatment method thereof
  • Moisture-resistant vitamin mineral tablet and moisture-resistant treatment method thereof
  • Moisture-resistant vitamin mineral tablet and moisture-resistant treatment method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example 1

[0066] Preparation Example 1 provides a method for choline particles:

[0067] Step 1: prepare a hydroxypropyl methylcellulose solution, weigh 20 kg of hydroxypropyl methylcellulose, add it to 313 kg of water, and stir at a stirring speed of 200 r / min for 1 h to obtain a hydroxypropyl methylcellulose solution.

[0068] Step 2: Weigh 50kg of choline bitartrate that has passed through a 40-mesh sieve after crushing, place it in a high-speed shearing wet granulator, then 15kg of low-substituted hydroxypropyl cellulose, mix for 10min under the condition of a stirring speed of 120r / min , and then add the hydroxypropyl methylcellulose solution in step S1, and stir for 5 minutes at a stirring speed of 120 r / min and a cutter speed of 1500 r / min to prepare wet granules.

[0069] Step 3: The wet granules are placed in the fluidized bed for drying. Drying conditions: the fluidized bed inlet air setting temperature is 80°C. When the moisture content of the granules reaches (2±0.5)%, the d...

preparation example 2

[0071] Preparation Example 2 provides a continuous granulator for preparing choline granules, and a method for preparing choline granules.

[0072] refer to figure 1 and figure 2 , the continuous granulator includes a cylindrical tower body 1, a columnar cavity is opened inside the tower body 1, and a circular block for dividing the tower body 1 into an upper cavity and a lower cavity is horizontally and fixedly connected in the tower body 1 Separator 11.

[0073] refer to figure 2 and image 3 , a mixing device 2 is installed above the partition plate 11 , and the mixing device 2 includes a circular bottom plate 21 fixedly connected to the top wall of the partition plate 11 , a top plate 22 and a material tank 23 fixedly connected to the top wall of the upper cavity. A circle of first chute 24 is provided on the side wall of the bottom plate 21 away from the partition plate 11 along the circumference of the bottom plate 21 , and a circle of the top plate 22 close to the...

preparation example 3

[0088] The difference between Preparation Example 3 and Preparation Example 2 is that step S2 is: weigh 50kg of choline bitartrate, 15kg of low-substituted hydroxypropyl cellulose, hydroxypropyl methylcellulose solution and 3kg of 40 mesh sieves after pulverizing. The auxiliary agents are respectively connected to the feeding hole 53 of the tower body 1 through pipes along the sliding direction of the feeding tank 23, and the material is put into the feeding tank 23 through the feeding hole 53, and the stirring speed in the feeding tank 23 is controlled to 120r / min. The rotating speed is 1500r / min, and the air inlet temperature is 80°C; the material obtained from the continuous granulator is taken out and granulated through an 18-mesh screen to obtain choline granules.

[0089] The preparation method of the auxiliary agent is: adding 3kg of sucrose to 10kg of water to melt, then heating and boiling to dryness, and continuing to heat up and cook to dryness to obtain a syrup mixt...

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Abstract

The invention relates to the field of tablet preparation, and particularly discloses a moisture-resistant vitamin mineral tablet and a moisture-resistant treatment method thereof, and the moisture-resistant vitamin mineral tablet is prepared from the following raw materials in parts by weight: 30-40 parts of vitamin C; 10 to 15 parts of vitamin E; 450 to 480 parts of mineral element particles; 20 to 30 parts of a vitamin premix; 240 to 250 parts of choline particles; 90 to 100 parts of low-substituted hydroxypropyl cellulose; 180 to 190 parts of microcrystalline cellulose; 20 to 30 parts of silicon dioxide; 10 to 12 parts of magnesium stearate; and 30-40 parts of a coating agent. The choline particles are obtained by mixing choline bitartrate with low-substituted hydroxypropyl cellulose and a hydroxypropyl methyl cellulose solution and granulating. The preparation method has the effects of improving the moisture resistance of the tablets and avoiding moisture absorption of materials in the intermediate link of tablet production.

Description

technical field [0001] The present application relates to the field of vitamin tablets, and more particularly, to a moisture-resistant vitamin-mineral tablet and a moisture-resistant treatment method thereof. Background technique [0002] Vitamins and minerals are nutrients that the human body needs, and people generally ingest them through diet and external supplements. Among them, solid preparation is a relatively common way of ingestion. [0003] During the storage of solid preparations, active ingredients such as drugs in the solid preparations and the polar hydroxyl groups of water molecules in the air are likely to form hydrogen bonds or generate other intermolecular forces, thus exhibiting the phenomenon of moisture absorption. After moisture absorption, the nutrients in the solid preparation will be degraded and oxidized, which will cause the solid preparation to crack and affect the stability of the product. For vitamin mineral tablets, because some vitamins (such...

Claims

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Application Information

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IPC IPC(8): A61K33/34A61K9/36A61K47/28A61K47/38A61P3/02B01J2/22B01F27/90B01F33/83B01F35/30B01F101/22A61K31/07A61K31/122A61K31/197A61K31/355A61K31/375A61K31/4188A61K31/4415A61K31/455A61K31/51A61K31/519A61K31/525A61K31/593A61K31/714A61K33/04A61K33/06A61K33/26A61K33/30A61K33/32
CPCA61K31/375A61K31/355A61K31/07A61K31/593A61K31/51A61K31/525A61K31/714A61K31/4415A61K31/122A61K31/455A61K31/519A61K31/4188A61K31/197A61K33/06A61K33/32A61K33/30A61K33/26A61K33/04A61K33/34A61K9/2054A61K9/2013A61K9/2866A61K9/2813B01J2/22A61P3/02A61K47/38A61K47/28A61K9/2095A61K2300/00Y02P60/87
Inventor 钟建荣杨善岩叶丽芳刘妍妍冯锋将冯旭俊
Owner HANGZHOU MINSHENG HEALTHCARE CO LTD
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