Preparation method of metal microneedle array and polymer microneedle patch

Abstract

The invention relates to the technical field of microneedle preparation, and discloses a preparation method of a metal microneedle array and a polymer microneedle patch, the metal microneedle array is prepared through a PG optical grinding or metal probe welding method, and the depth-to-width ratio of the metal microneedle array prepared through PG optical grinding is high. The metal microneedles are good in repeatability, precision, average degree and uniformity, meanwhile, the problem that a large needle distance is needed when a single microneedle is ground is solved, and the method has the advantages that the speed is high, efficiency is high, and batch production of the metal microneedle array is easy to achieve. A microneedle main template is prepared by adopting a metal probe welding method, so that the length, the form and the overall array shape of each microneedle can be conveniently changed. The polymer microneedle patch template is prepared by adopting a die combination scheme, the preparation and forming of microneedles in various shapes can be realized on the basis of not modifying the shape of a metal array, and the method has the advantages of low cost, high efficiency, high flexibility and the like.

Description

technical field [0001] The invention relates to the technical field of microneedle preparation, in particular to a method for preparing a metal microneedle array and a polymer microneedle patch. Background technique [0002] As a new type of transdermal drug delivery technology, microneedles have attracted widespread attention in the fields of medical aesthetics and medicine due to their advantages of high efficiency, painlessness, and ease of application. Microneedles are applied to the surface of the skin to form micro / nano channels on the surface of the skin, enhance the permeability of the skin surface, and promote the entry of active substances / drugs inside or coated on the surface of the microneedles into the skin, thereby exerting the functions of these molecules; or The microneedles are only used as a tool to create channels that enhance the penetration of subsequently applied substances like within the skin. [0003] Microneedles made of metal materials through mic...

AI Technical Summary

Problems solved by technology

[0006] In view of the problems of low microneedle precision, low flatness, and difficult control of uniformity in metal microneedle arrays prepared by existing processing methods, the purpose of the present invention is to provide a method for preparing metal microneedle arrays, which is not only relatively easy to realize Array production of metal microneedles, and the obtained metal microneedles have high precision, high flatness and good uniformity

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