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Multi-arm star-shaped polymer assembled micelle and preparation method thereof

A multi-armed star polymer technology, applied in the field of multi-armed star-shaped polymer assembly micelles and its preparation, can solve the problems of low yield and slow preparation rate, and achieve small size, small size dispersion, and expanded concentration range effect

Pending Publication Date: 2022-06-24
XI AN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] In order to overcome the shortcomings of low yield and slow preparation rate, the present invention proposes a scalable and efficient preparation of multi-arm star-shaped polymer assembly micelles and its preparation method, which can prepare polymer micelles with uniform size in water, with The characteristics of rapidity, high efficiency and simple method lay the foundation for the large-scale application of polymer micelles in drug delivery, catalyst entrapment and other fields

Method used

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  • Multi-arm star-shaped polymer assembled micelle and preparation method thereof
  • Multi-arm star-shaped polymer assembled micelle and preparation method thereof
  • Multi-arm star-shaped polymer assembled micelle and preparation method thereof

Examples

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Effect test

Embodiment 1

[0044] Preparation of 12-arm star amphiphilic block copolymer (PtBA-b-PHEMA) 12 polymer solution;

[0045] Take 20mg of copolymer (PtBA-b-PHEMA) 12 Dissolved in 10 mL of co-solvent THF, sonicated for 30 min and allowed to stand overnight to prepare a 2 mg / mL polymer solution.

Embodiment 2

[0047] Preparation of 16-arm star amphiphilic block copolymer (PS-b-PEG) 16 polymer solution

[0048] Take 100mg of polymer (PS-b-PEG) 16 Dissolved in 10 mL of co-solvent DMF, ultrasonicated for 30 min and allowed to stand overnight to prepare a 10 mg / mL polymer solution.

Embodiment 3

[0050] Preparation of 21-arm star amphiphilic block copolymer (PS-b-PEG) 21 polymer solution

[0051] Take 20mg of polymer (PS-b-PEG) 21 Dissolved in 10 mL of co-solvent DMF, sonicated for 30 min and allowed to stand overnight to prepare a 2 mg / mL polymer solution.

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Abstract

The invention discloses a multi-arm star-shaped polymer assembled micelle and a preparation method thereof.The preparation method comprises the specific steps that S1, a multi-arm star-shaped block copolymer with a (A-b-B) f structure is dissolved in a cosolvent of a block A and a block B, and a copolymer solution is obtained; s2, dropwise adding the copolymer solution into water to obtain an assembled micelle mixed solution; and S3, removing the organic solvent in the assembled micelle mixed solution to obtain the multi-arm star-shaped polymer assembled micelle. The preparation method of the multi-arm star-shaped polymer assembled micelle can be used for preparing the polymer micelle with uniform size in water, has the characteristics of rapidness, high efficiency and simple method, and lays a foundation for large-scale application of the polymer micelle in the fields of drug delivery, catalyst entrapment and the like.

Description

technical field [0001] The invention belongs to the technical field of polymer preparation, in particular to a multi-arm star polymer assembled micelle and a preparation method thereof. Background technique [0002] Micelles have broad application prospects in biotechnology and biomedicine such as drug delivery and bioimaging. Polymeric micelles are mainly prepared by self-assembly of amphiphilic block copolymers in selective solvents. [0003] Traditional solution self-assembly is usually based on co-solvent methods. First, the block copolymer is dissolved in a co-solvent to form a low concentration polymer dilute solution (usually below 2 wt%); second, a selective solvent, such as water, is slowly added to the solution, when the selective solvent content increases to a certain At a certain concentration, the polymer undergoes microphase separation and forms self-assembled nanoparticles such as micelles. [0004] The above-mentioned micelle preparation process currently ...

Claims

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Application Information

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IPC IPC(8): C08J3/07C08L53/00
CPCC08J3/07C08J2353/00
Inventor 张启路孙雅薇刘峰
Owner XI AN JIAOTONG UNIV
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