The invention relates to the technical field of organic
chemical synthesis, and in particular, relates to a synthetic method of a
fluorene fluoride compound, wherein the synthetic method of the
fluorene fluoride compound comprises the following steps: S1, adding an
organic solvent into a reaction kettle, adding a compound represented by a formula (I) and a fluorinating agent into the reaction kettle, and uniformly stirring and mixing; S2, sequentially adding an auxiliary agent and a reaction
solvent into the mixture obtained in the step S1; and S3, setting the
reaction temperature and the reaction time of the reaction kettle, continuously stirring while reacting, naturally cooling the product to
room temperature after the reaction is completed, filtering, fully washing with a saturated
sodium carbonate aqueous solution, adding
chloroform, extracting for 2-3 times, merging organic phases,
drying with
anhydrous sodium sulfate, concentrating under reduced pressure, enabling the obtained residue to pass through
silica gel column chromatography, and leaching the
mixed solution of
acetone and
petroleum ether to obtain a compound represented by a formula (II). According to the method, thefluorinating agent, the auxiliary agent and the reaction
solvent are comprehensively selected and cooperated, so that the target product can be obtained at high yield.