30 results about "Oxazolidinedione" patented technology

Indoles of Formula I having —X-aryl-(CH2)x-oxazolidinedione and —X-heteroaryl-(CH2)x-oxazolidinedione substituents on the N atom of the indole ring, where x is 0 or 1, and —X— is a bond or —CH2—, and their thiazolidinedione analogs, are PPAR gamma agonists or partial agonists and are useful in the treatment and control of type II diabetes, including hyperglycemia, dyslipidemia, hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, and obesity that are often associated with type 2 diabetes.

Phenoxyphenyl and phenoxybenzyl oxazolidine-2,4-diones and thiazolidine-2,4-diones of formula (I) are agonists or partial agonists of PPAR gamma and are useful in the treatment and control of hyperglycemia that is symptomatic of type II diabetes, as well as dyslipidemia, hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, and obesity that are often associated with type 2 diabetes.

Indoles of Formula (I) having -X-aryl-(CH2)x#191-oxazolidinedione and -X-heteroaryl-(CH2)X-oxazolidinedione substituents on the N atom of the indole ring, where x is 0 or 1, and -X-is a bond or -CH2-, and their thiazolidinedione analogs, are PPAR gamma agonists or partial agonists and are useful in the treatment and control of type II diabetes, including hyperglycemia, dyslipidemia, hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, and obesity that are often associated with type 2 diabetes.

Novel diphenylethylene compounds and derivatives thereof containing thiazolidinedione or oxazolidinedione moieties are provided which are effective in lowering blood glucose level, serum insulin, triglyceride and free fatty acid levels in animal models of Type II diabetes. In contrast to previously reported thiazolidinedione compounds, known to lower leptin levels, the present compounds increase leptin levels and have no known liver toxicity. The compounds are disclosed as useful for a variety of treatments including the treatment of inflammation, inflammatory and immunological diseases, insulin resistance, hyperlipidemia, coronary artery disease, cancer and multiple sclerosis.

Novel diphenylethylene compounds and derivatives thereof containing thiazolidinedione or oxazolidinedione moieties are provided which are effective in lowering blood glucose level, serum insulin, triglyceride and free fatty acid levels in animal models of Type II diabetes. The compounds are disclosed as useful for a variety of treatments including the treatment of inflammation, inflammatory and immunological diseases, insulin resistance, hyperlipidemia, coronary artery disease, cancer and multiple sclerosis.

Phenoxyphenyl and phenoxybenzyl oxazolidine-2,4-diones and thiazolidine-2,4-diones are agonists or partial agonists of PPAR gamma and are useful in the treatment and control of hyperglycemia that is symptomatic of type II diabetes, as well as dyslipidemia, hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, and obesity that are often associated with type 2 diabetes.

The invention relates to the field of pharmaceutics and more specifically to cycloalkylamidoacid compositions useful in the preparation of cycloalkyaminoacids and oxazolidinediones, and processes for making cycloamidoacidsX and R are defined herein.

A resist composition is provided comprising a polymer comprising recurring units (a) having an oxazolidinedione, thioxooxazolidinone, thiazolidinedione or thioxothiazolidinone structure and recurring unit (b1) having an acid labile group-substituted carboxyl group and / or recurring units (b2) having an acid labile group-substituted phenolic hydroxyl group. The resist composition suppresses acid diffusion, exhibits a high resolution, and forms a pattern of satisfactory profile with low edge roughness.

The invention provides a method used for synthesizing 2, 4-oxazolidinedione compound through organic amine catalyzing CO2, and belongs to the technical field of organic synthesis, pesticide, and medical chemistry. The method comprises following steps: acetylene amide raw material and a solvent are introduced into a reaction bottle containing a magneton, an organic base is added as a catalyst, thereaction bottle is introduced into a Schlink bottle filled with carbon dioxide gas, stirring reaction is carried out for 1 to 6h at room temperature, after reaction, an obtained reaction liquid is pumped out from the reaction bottle, an obtained crude product is subjected to column chromatography so as to obtain the 2, 4-oxazolidinedione compound. According to the method, the simple organic base of a catalytic amount is adopted to replace a conventional metal catalyst; reaction is clean; reaction conditions are mild; function group tolerance is high; conversion rate and stereoselectivity are high, and the application prospect in the fields of organic synthesis, pesticide, and medicine is promising.

The invention provides a synthesis method of an oxazolidinedione compound represented by formula (I) shown in the specification. The method comprises steps as follows: a compound represented by formula (II) shown in the specification, a compound represented by formula (III) shown in the specification and a compound represented by formula (IV) shown in the specification have a reaction in a solvent in the carbon dioxide atmosphere in the presence of a catalyst, a base and an aid, so that the oxazolidinedione compound represented by formula (I) is obtained; R1 and R2 are H, C1-C6 alkyl groups, C1-C6 alkoxy groups or halogens respectively and independently. According to the method, the good technical effect is realized through combination and cooperation of proper catalyst, base, aid and solvent systems, and the method has very broad market application prospect in the field of drug intermediate synthesis.

The invention discloses a synthesis method of selenooxazolidine-2.4-diketone promoted by visible light, using N-Boc-protected acrylamide and diselenide as reaction raw materials, and performing a stirring reaction under certain temperature conditions and light source irradiation , to obtain selenooxazolidine-2,4-dione compound. The reaction condition of the method is simple, the yield of the product is high, and the preparation of the selenooxazolidine-2,4-diketone heterocyclic compound from the raw material of acrylamide is realized for the first time; It has the advantages of wide range, opens up a new synthetic route and method for selenooxazolidine-2,4-diketone heterocyclic compounds, and has good application potential and research value.

The invention discloses a synthesis method of the 3-(2-phenyl ethyl)-5-[2, 3, 6, 7-tetrahydrogen-1H, 5H-dibenzo [ij] quinoline-9-ene]-2, 4-oxazolidine dione; the steps first uses the hydroxy ethyl acetate and urea as the raw materials to make the oxazolidine-2 ,4-dione; then the oxazolidine-2 ,4-dione reacts with the beta-bromophenyl ethane to make the 3-phenethyl-oxazolidine-2, 4-dione; the 3-phenethyl-oxazolidine-2, 4-dione then reacts with the 2,3,6,7-tetrahydrogen-1 H, 5H-pyrido [3,2,1-ij] quinoline-9-formaldehyde to make the product 3-(2-phenyl ethyl)-5-[2,3,6, 7-tetrahydrogen-1 H, 5H-benzo [ij] quinoline-9-ene]-2,4-oxazolidine dione. The invention is of the simple process, the easily accessible and cheap raw materials, the high production rate, the low cost and the suitableness forthe industrial production.