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Tyrosinase activity inhibitor and skin care product with synergistic whitening effect

An active inhibitor, tyrosinase technology, applied in the field of skin care products, can solve the problem of lack of synergistic effect and other problems

Pending Publication Date: 2022-07-01
HEFEI KADIER COSMETIC CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although there are many whitening products with multiple whitening ingredients on the market, they basically stay in the simple superposition of ingredients with the same mechanism. There is no scientific and rigorous evaluation system to optimize the whitening effect under the same mechanism, and there is no obvious synergistic effect.

Method used

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  • Tyrosinase activity inhibitor and skin care product with synergistic whitening effect
  • Tyrosinase activity inhibitor and skin care product with synergistic whitening effect
  • Tyrosinase activity inhibitor and skin care product with synergistic whitening effect

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-4

[0055] Get 4-n-butyl resorcinol and polyglutamic acid as tyrosinase activity inhibitor, specifically by mass ratio of 4-n-butyl resorcinol and polyglutamic acid 0.00013:1 (embodiment 1), 0.004:1 (Example 2), 0.000013:1 (Example 3), and 0.0004:1 (Example 4) were mixed to obtain a tyrosinase inhibitor.

[0056] During the test, the tyrosinase activity inhibitors of Examples 1-4 were respectively dissolved in PB buffer of pH 6.8 to obtain sample solutions of different concentrations. The concentrations of the sample solutions are shown in Table 3.

Embodiment 5-8

[0058] Take glutathione and polyglutamic acid as the tyrosinase activity inhibitor, specifically, glutathione and polyglutamic acid in a mass ratio of 0.1:1 (Example 5), 3:1 (Example 6 ), 0.033:1 (Example 7) and 1:1 (Example 8) were mixed to obtain a tyrosinase inhibitor.

[0059] During the test, the tyrosinase activity inhibitors of Examples 5-8 were respectively dissolved in PB buffer of pH 6.8 to obtain sample solutions of different concentrations. The concentrations of the sample solutions are shown in Table 3.

Embodiment 9-12

[0061] Take nicotinamide and polyglutamic acid as tyrosinase activity inhibitors, specifically, nicotinamide and polyglutamic acid are mass ratios of 13.33:1 (Example 9), 400:1 (Example 10), 1.33: After mixing 1 (Example 11) and 40:1 (Example 11), a tyrosinase inhibitor was obtained.

[0062] During the test, the tyrosinase activity inhibitors of Examples 9-11 were respectively dissolved in PB buffer of pH 6.8 to obtain sample solutions of different concentrations. The concentrations of the sample solutions are shown in Table 3.

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PUM

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Abstract

The invention discloses a tyrosinase activity inhibitor and a skin care product with synergistic whitening effects. The tyrosinase activity inhibitor can synergistically improve the activity inhibition effect on tyrosinase. The skin care product containing the inhibitor not only can inhibit the generation of melanin from the source, but also can be compounded with other components, and the skin care product can inhibit the melanin generation by utilizing various mechanisms of inhibiting tyrosinase activity, resisting oxidation, scavenging free radicals, reducing melanin intermediates, inhibiting melanin transfer, accelerating melanin metabolism and the like. The whitening effect with high efficiency, low irritation and synergistic effect is achieved.

Description

technical field [0001] The invention belongs to the technical field of skin care products, and in particular relates to a tyrosinase activity inhibitor and a skin care product with synergistic whitening effect. Background technique [0002] The so-called "one white cover a hundred ugliness", whitening has always been the pursuit of Asian women. With the improvement of people's living standards and aesthetic standards, fair and clean skin is more and more respected. In the skin care product market, all kinds of whitening products emerge in an endless stream, and the whitening market has become a segmented field where major brands at home and abroad are vying for strength. How to safely and effectively whiten is a top priority in the skin care market. [0003] The shade of skin color is regulated by many factors, but still mainly depends on the content and distribution of melanin. Melanin is produced by melanocytes, which form an epidermal unit with keratinocytes in a 1:36 ...

Claims

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Application Information

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IPC IPC(8): A61K8/88A61K8/34A61K8/64A61K8/67A61Q19/02
CPCA61K8/64A61K8/675A61K8/347A61K8/88A61K8/676A61Q19/02A61K2800/5922A61K2800/782Y02A50/30
Inventor 邬婧戚仕梅余海霞吴振坤
Owner HEFEI KADIER COSMETIC CO LTD
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