2, 2-dipyridyl and uracil-1-acetic acid copper tetrafluoroborate complex as well as preparation method and application thereof

A technology of copper tetrafluoroborate tetrafluoroborate and uracil based on acetic acid, applied in the field of copper complexes, can solve the problems of low anticancer activity and the like, and achieve the effects of improving anticancer activity and improving inhibitory activity

Pending Publication Date: 2022-07-05
INST OF NEW MATERIALS & IND TECH WENZHOU UNIV
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Problems solved by technology

[0004] Based on this, the present invention provides a copper complex of 2,2'-bipyridine and uracil-1-yl acetic acid tetrafluoroborate to solve the relatively low anticancer activity of copper complexes of 5-fluorouracil existing in the prior art. low technical issues

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  • 2, 2-dipyridyl and uracil-1-acetic acid copper tetrafluoroborate complex as well as preparation method and application thereof
  • 2, 2-dipyridyl and uracil-1-acetic acid copper tetrafluoroborate complex as well as preparation method and application thereof
  • 2, 2-dipyridyl and uracil-1-acetic acid copper tetrafluoroborate complex as well as preparation method and application thereof

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[0041] It should be noted that the embodiments of the present invention and the features of the embodiments may be combined with each other under the condition of no conflict. The technical solutions of the present invention will be further described below with reference to the embodiments of the present invention, and the present invention is not limited to the following specific embodiments.

[0042] In one embodiment, a complex of 2,2'-bipyridine and uracil-1-yl acetate tetrafluoroborate copper, the 2,2'-bipyridine and uracil-1-yl acetate copper tetrafluoroborate The structural formula of the complex is:

[0043]

[0044] The 2,2'-bipyridine and uracil-1-ylacetic acid tetrafluoroborate copper complex belongs to the triclinic crystal system, and the space group is P-1; the unit cell parameters are: α=73.5070(10)°, β=89.4130(10)°, γ=61.5200(10)°.

[0045] The performance analysis of the 2,2'-bipyridine and uracil-1-ylacetic acid tetrafluoroborate copper complex (hereina...

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Abstract

The invention provides a 2, 2 '-dipyridyl and uracine-1-acetic acid copper tetrafluoroborate complex as well as a preparation method and application thereof, and belongs to the technical field of copper complexes. The preparation method comprises the following steps: preparing a 2, 2 '-dipyridyl and uracil 1-base acetic acid copper tetrafluoroborate complex (X1) from uracil 1-base acetic acid, tetrafluoroborate tetrafluoroborate (acetonitrile) copper (I) and 2, 2'-dipyridyl as raw materials, and preparing the 2, 2 '-dipyridyl and uracil 1-base acetic acid copper tetrafluoroborate complex (X1). The basic unit of X1 is composed of a copper ion, two 2, 2-bipyridine molecules, a uracil-1-yl acetic acid anion and a free tetrafluoroborate, and the geometric shape around the copper ion is a distorted octahedron. Experiments show that the interaction mode of X1 and CT-DNA is an electrostatic mode, and the quenching constant KSV of X1 and a calf thymus DNA system with ethidium bromide (EB) is 4.102 * 10 < 3 > M <-1 >. The inhibitory activity of the compound on MDA-MB-231 and HCT116 is remarkably improved, IC50 results are respectively 12.32 +/-1.58 and 8.56 +/-0.52, and the anti-cancer activity of the compound is further improved after the compound is irradiated by an infrared lamp.

Description

technical field [0001] The invention belongs to the technical field of copper complexes, and in particular relates to a copper complex of 2,2'-bipyridine and uracil-1-ylacetic acid tetrafluoroborate and a preparation method and application thereof. Background technique [0002] 5-Fluorouracil can inhibit thymine nucleotide synthase, block the conversion of deoxypyrimidine nucleotides into thymine nucleotides, interfere with DNA synthesis, and also have a certain inhibitory effect on RNA synthesis. It is clinically used to relieve or inhibit colon cancer, rectal cancer, stomach cancer, breast cancer, liver cancer, etc. However, 5-fluorouracil has serious toxic and side effects, causing gastrointestinal discomfort and damage to the nervous system. In severe cases, it can cause cerebral palsy and cerebellar degeneration. [0003] Studies have shown that 5-fluorouracil derivatives and their metal complexes or clusters have good anticancer activity. For example, the Chinese inv...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07F1/08A61K31/555A61P35/00
CPCC07F1/08C07F1/005A61P35/00C07B2200/13
Inventor 吴东林叶玲迪奚云红胡茂林
Owner INST OF NEW MATERIALS & IND TECH WENZHOU UNIV
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