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Oral microbial gene marker for predicting neutralizing antibody level of new coronal pneumonia patient after one year and application of oral microbial gene marker

A technology of oral microorganisms and genetic markers, which is applied in the fields of plant genetic improvement, determination/inspection of microorganisms, and applications, and can solve problems such as oral microbial models that have not been reported before.

Active Publication Date: 2022-07-05
THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, an oral microbial model for predicting neutralizing antibody levels in patients with COVID-19 after one year has not been reported

Method used

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  • Oral microbial gene marker for predicting neutralizing antibody level of new coronal pneumonia patient after one year and application of oral microbial gene marker
  • Oral microbial gene marker for predicting neutralizing antibody level of new coronal pneumonia patient after one year and application of oral microbial gene marker
  • Oral microbial gene marker for predicting neutralizing antibody level of new coronal pneumonia patient after one year and application of oral microbial gene marker

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Embodiment Construction

[0059] The present invention will be further described below in conjunction with the embodiments, but the protection content of the present invention is not limited to these embodiments.

[0060] The methods used in the following examples are conventional methods unless otherwise specified. The materials or reagents required in the following examples are obtained from open commercial channels unless otherwise specified.

[0061] In the present invention, 16SrDNA Miseq sequencing of oral flora is performed by collecting the tongue coating samples of the subjects, extracting the total microbial DNA. Based on high-throughput sequencing data, an oral microbiome prediction model for neutralizing antibody levels in patients with new coronary pneumonia after one year was established, and a prevalence of disease (POD) index with neutralizing antibody inhibition rates less than 70% after one year was established; The POD index can be used to calculate its predictive power.

[0062] T...

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Abstract

The invention belongs to the technical field of biological medicine, and particularly relates to an oral microorganism gene marker for predicting the neutralizing antibody level of a new coronal pneumonia patient after one year and application of the oral microorganism gene marker. The invention provides an oral microbial gene marker for predicting the neutralizing antibody level of a new coronal pneumonia patient after one year. The oral microbial gene marker consists of nine microbial genes as shown in SEQ ID NO: 1-9. The microbial gene prediction model provided by the invention realizes good prediction ability in new coronal pneumonia patients with the neutralizing antibody inhibition rate higher than 70% after one year and the neutralizing antibody inhibition rate lower than 70% after one year.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to an oral microbial gene marker for predicting the level of neutralizing antibody in patients with new coronary pneumonia one year later and an application thereof. Background technique [0002] Since the outbreak of Corona Virus Disease 2019 (COVID-19), as of March 1, 2022, the cumulative number of confirmed cases worldwide has exceeded 430 million, and the cumulative number of cured people has exceeded 360 million. Common clinical symptoms of COVID-19 are fever, cough, fatigue, expectoration, shortness of breath, myalgia, arthralgia, etc. Pathophysiological changes caused by COVID-19 can have long-term effects on the body and trigger persistent symptoms. Studies have shown that severely ill patients with COVID-19 still have symptoms of severe lung damage up to 3 months after they are discharged from hospital. A 6-month follow-up of COVID-19 patients found that f...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/689C12N15/31C12N15/11
CPCC12Q1/689C07K14/195Y02A90/10
Inventor 任志刚饶本臣余博
Owner THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIV