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Anticoagulation and rapid endothelialization coating for degradable plugging device and preparation method of anticoagulation and rapid endothelialization coating

An occluder and anticoagulation technology, applied in the field of biomedical engineering functional materials, can solve problems such as poor endothelialization repair

Pending Publication Date: 2022-07-15
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Aiming at the clinical status of coagulation and poor endothelial repair after implantation of existing cardiac occluder materials, the present invention provides a functional coating that can be used for surface modification of biodegradable occluder materials and a preparation method thereof

Method used

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  • Anticoagulation and rapid endothelialization coating for degradable plugging device and preparation method of anticoagulation and rapid endothelialization coating
  • Anticoagulation and rapid endothelialization coating for degradable plugging device and preparation method of anticoagulation and rapid endothelialization coating

Examples

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Effect test

Embodiment 1

[0028] A coating capable of realizing anticoagulation and rapid endothelialization of a degradable occluder and a preparation method thereof, comprising the following steps:

[0029] (1) Plasma treatment is performed on the degradable occluder material (poly-dioxanone) to obtain hydroxyl functional groups;

[0030] (2) preparing polymer A with anticoagulation function by free radical polymerization;

[0031] (3) taking water as a solvent, mixing the polymer obtained in step (2) with hyaluronic acid, as a coating formula solution;

[0032] (4) Immerse the degradable occluder material obtained in step (1) into the coating formulation solution obtained in step (3), add 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide Amine hydrochloride (pH 5.5, 0.02wt%) was taken out after reacting for 6 hours at 60°C, washed with deionized water and dried to obtain the target plug.

[0033] Wherein, the synthesis process of anticoagulant polymer A is carried out in the following manner:

Synthetic example 1

[0034] Synthesis Example 1: Anticoagulant polymer A can be synthesized according to the following feeding concentrations: methacryloyloxyethylphosphorylcholine (0.05wt%), methacrylamidopropyl hydrochloride (0.1wt%) and Lauryl methacrylate (0.2 wt%), the initiator is azobisisobutyronitrile.

Synthetic example 2

[0035] Synthesis Example 2: Anticoagulant polymer A can be synthesized according to the following feeding concentrations: methacryloyloxyethylphosphorylcholine (0.05wt%), methacrylamidopropyl hydrochloride (0.25wt%), Methacryloxypropyltrimethoxysilane (0.2 wt%), and the initiator is azobisisobutyronitrile.

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Abstract

The invention discloses an anticoagulation and rapid endothelialization coating for a degradable plugging device and a preparation method of the anticoagulation and rapid endothelialization coating, relates to the technical field of biomedical engineering functional materials, and provides the anticoagulation and rapid endothelialization coating for the degradable plugging device. Comprising a polymer A with an anticoagulation function, a functional substance B with an endothelial repair promoting function and a hydroxyl functional group capable of degrading surface modification of the plugging device, and the polymer A and the functional substance B are coupled through a cross-linking agent and can be connected with the hydroxyl functional group. In the preparation process, the degradable plugging device body material is treated by plasma or a strong oxidant, and the surface of the obtained hydroxyl functional group provides a site for effective physical and chemical crosslinking between the surface of the obtained hydroxyl functional group and a chemical group of a polymer A in the follow-up process. Through chemical crosslinking between the anticoagulation module and the endothelium promoting compound module, an endothelium promoting compound can be effectively introduced on the premise that the anticoagulation function is guaranteed, and rapid repair after the plugging device is implanted is achieved.

Description

technical field [0001] The invention relates to the technical field of biomedical engineering functional materials, in particular to an anticoagulation and rapid endothelialization coating for a degradable occluder and a preparation method thereof. Background technique [0002] Congenital heart disease refers to the abnormal anatomical structure caused by the abnormal formation or development of the heart and large blood vessels during embryonic development, or the failure of the channels that should be automatically closed after birth to be closed (normal in the fetus). The incidence of congenital heart disease should not be underestimated, accounting for 0.4% to 1% of living babies, which means that there are 150,000 to 200,000 new congenital heart disease patients in my country every year, which mainly include atrial septal defect, ventricular septal defect, oval The hole is not necessarily, the ductus arteriosus is patent, etc. In addition, atrial fibrillation is one of ...

Claims

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Application Information

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IPC IPC(8): A61L31/10A61L31/14A61L31/16A61L33/06
CPCA61L31/10A61L31/16A61L31/148A61L33/0088A61L33/064A61L2300/216A61L2300/252A61L2300/232A61L2300/42A61L2300/412A61L2300/414A61L2300/606A61L2420/06A61L2400/18
Inventor 王云兵罗日方杨立
Owner SICHUAN UNIV
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