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Application of paeoniflorin in preparation of medicine for treating IV-type renal heart syndrome

A syndrome and drug technology, applied in the field of traditional Chinese medicine, can solve the problems of less research on pharmacological effects and no reports on the application of type IV renal-cardiac syndrome, so as to improve cardiac systolic and diastolic functions, and reduce cardiac fibrosis , improve the effect of heart failure

Pending Publication Date: 2022-07-22
THE FIRST AFFILIATED HOSPITAL OF GUANGZHOU UNIV OF CHINESE MEDICINE
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] Lactiflorin is a monoterpene glycoside mainly derived from the roots of Paeonia lactiflora Pall, Paeonia veitchii Lynch, Paeonia obovert Maxim and Paeonia willmottiaeStapf of Ranunculaceae plants, and its pharmacological action research Rarely, there is no report on its application in the treatment of type IV renal cardiomyopathy

Method used

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  • Application of paeoniflorin in preparation of medicine for treating IV-type renal heart syndrome
  • Application of paeoniflorin in preparation of medicine for treating IV-type renal heart syndrome
  • Application of paeoniflorin in preparation of medicine for treating IV-type renal heart syndrome

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Embodiment 1

[0029] This example studies the therapeutic effect of paeoniflorin on type IV renal-heart syndrome model mice.

[0030] 1. Materials and methods

[0031] 1. Drugs

[0032] Paeoniflorin was purchased from Chengdu Mansite Biotechnology Co., Ltd., powder, and suspended in 1% sodium carboxymethylcellulose solution (100 mL sterile water + 1 g CMC-Na, shake well).

[0033] 2. Animal models

[0034] 6-week-old male C57BL / 6 mice, weighing 23 ± 1 g, were purchased from Guangzhou University of Traditional Chinese Medicine (certificate number, SYXK (Guangdong) 2018-0001), and all animal experiments were carried out in accordance with the "Guidelines for the Care and Use of Laboratory Animals" , and was approved by the Ethics Committee of Guangzhou University of Traditional Chinese Medicine (approval number 20180122003). After one week of adaptive feeding, the male mice were randomly divided into the following three groups: sham operation group (Sham), 5 / 6 nephrectomy group (Npx) and 5...

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Abstract

The invention provides application of paeoniflorin in preparation of a medicine for treating IV-type renal heart syndrome. The invention innovatively discovers that the paeoniflorin can effectively improve the systolic function and diastolic function of a CRCS animal model, relieve the cardiac fibrosis state of the CRCS animal model, relieve the myocardial hypertrophy state of the CRCS animal model, reduce the expression level of inflammatory cytokines and improve the expression level of anti-inflammatory cytokines. Therefore, the paeoniflorin can obviously improve the heart failure of the animal model with the IV-type renal heart syndrome, and can be used for treating the IV-type renal heart syndrome. The invention provides a new medication choice for the treatment of patients with the type IV renal heart syndrome, and has the advantages of wide medicine source, definite components and dosage, safe medication and no obvious side effect.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and particularly relates to the application of paeoniflorin in preparing a medicine for treating type IV renal-heart syndrome. Background technique [0002] Cardiovascular disease (CVD) has become one of the most common and serious complications in patients with chronic kidney disease (CKD). Type IV renocardiac syndrome or chronic renocardiac syndrome (CRCS) refers to a syndrome in which chronic kidney disease leads to cardiac hypofunction, cardiac hypertrophy and other adverse cardiovascular events. Kidney disease is thought to be a major contributor to accelerated ischemic heart disease, causing pressure and volume overload, resulting in left ventricular hypertrophy and other cardiovascular events. Cardiovascular-related diseases account for more than 50% of the causes of death in chronic kidney disease, and this proportion increases exponentially with the progressive dete...

Claims

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Application Information

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IPC IPC(8): A61K31/704A61P13/12A61P9/00A61P9/04A61P29/00
CPCA61K31/704A61P13/12A61P9/00A61P9/04A61P29/00
Inventor 鲁路黎欢刘欣倪世豪
Owner THE FIRST AFFILIATED HOSPITAL OF GUANGZHOU UNIV OF CHINESE MEDICINE
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