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Method for synthesizing 2, 6-dichlorotoluene by directionally chlorinating o-chlorotoluene with novel composite catalyst

A technology of composite catalyst and o-chlorotoluene, applied in chemical instruments and methods, organic chemistry, preparation of halogenated hydrocarbons, etc., can solve the problems of long process flow, many reaction steps, low yield, etc. Simple steps and high yield

Pending Publication Date: 2022-07-22
NANJING UNIV OF TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The direct chlorination of o-chlorotoluene in the present invention has a wide range of sources of raw materials and a simple process, which can improve the selectivity of 2,6-dichlorotoluene in its isomer products, and solve the problem of many reaction steps and technical problems in other methods. The problem of long process and low yield

Method used

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  • Method for synthesizing 2, 6-dichlorotoluene by directionally chlorinating o-chlorotoluene with novel composite catalyst
  • Method for synthesizing 2, 6-dichlorotoluene by directionally chlorinating o-chlorotoluene with novel composite catalyst

Examples

Experimental program
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Effect test

example 1

[0030] Take a 500ml four-necked flask, add 100g of o-chlorotoluene, weigh 3g of anhydrous aluminum chloride and 1g of triethylamine under inert gas conditions, respectively, weigh the 3g of anhydrous aluminum chloride and 1g of the above-mentioned steps. Triethylamine was added to the above-mentioned four-necked flasks respectively; the four-necked flasks were placed in an oil bath, and heated and stirred for 6h under the condition of passing chlorine gas. After 6 hours of reaction, samples were taken for analysis.

[0031] The conversion of raw materials in the sample was 59.18%, and the selectivity of 2,6-dichlorotoluene was 35.62%.

example 2

[0033] Take a 500mL four-necked flask, add 95g of o-chlorotoluene, weigh 3g of anhydrous aluminum chloride and 1g of triethylamine under inert gas conditions, respectively, weigh 3g of anhydrous aluminum chloride and 1g of the above-mentioned steps. Triethylamine was added to the above-mentioned four-necked flasks respectively; the four-necked flasks were placed in an oil bath, and heated and stirred for 6h under the condition of passing chlorine gas. After 6 hours of reaction, samples were taken for analysis.

[0034] The conversion of raw materials in the sample was 57.80%, and the selectivity of 2,6-dichlorotoluene was 35.59%.

example 3

[0036] Take a 500mL four-necked flask, add 105g of o-chlorotoluene, weigh 3.2g of anhydrous aluminum chloride and 1.1g of triethylamine under inert gas conditions, and weigh 3.2g of anhydrous chlorinated Aluminum and 1.1 g of triethylamine were respectively added to the above-mentioned four-necked flask; the four-necked flask was placed in an oil bath, and heated and stirred for 6.5h under the condition of passing chlorine gas. After 6.5 hours of reaction, samples were taken for analysis.

[0037] The conversion of raw materials in the sample was 59.79%, and the selectivity of 2,6-dichlorotoluene was 35.45%.

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Abstract

The invention relates to a method for synthesizing 2, 6-dichlorotoluene by directionally chlorinating o-chlorotoluene with a novel composite catalyst, and belongs to the technical field of chemical synthesis. The method comprises the following steps: mixing aluminum trichloride and triethylamine salt according to a certain proportion under the protection of inert gas, adding the mixture into o-chlorotoluene, and stirring and reacting for 6-6.5 hours under the condition of introducing chlorine; after the reaction is finished, the raw material conversion rate is 60-65%, and the selectivity of the target product 2, 6-dichlorotoluene is stabilized at 34.5-35.7%. According to the method, the selectivity of 2, 6-dichlorotoluene is greatly improved, the yield of byproducts is relatively low, and compared with other methods for synthesizing 2, 6-dichlorotoluene, the amount of three wastes is low, the reaction steps are simple, the yield is high, the equipment investment is low, and the method has great significance on industrial production of 2, 6-dichlorotoluene.

Description

technical field [0001] The invention relates to a method for directional chlorination of o-chlorotoluene to synthesize 2,6-dichlorotoluene by a novel composite catalyst, and belongs to the technical field of chemical synthesis. Background technique [0002] At present, 2,6-dichlorotoluene is an important fine chemical raw material for the manufacture of pigments, dyes, medicines, herbicides, fungicides, insecticides and other chemical products. Using 2,6-dichlorotoluene as raw material, 2,6-dichlorobenzaldehyde can be prepared by chlorinated hydrolysis of side chain or direct oxidation, which can be further processed to synthesize dye acid medium bleaching blue B for wool fabric dyeing, Pharmaceutical intermediate 2,6-dichlorobenzaldehyde oxime and diclofenac for pharmaceutical use; 2,6-dichlorotoluene can be synthesized by ammonia oxidation to synthesize herbicide 2,6-dichlorobenzonitrile, which can be further processed and synthesized Fluorinated acylurea insecticides, pe...

Claims

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Application Information

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IPC IPC(8): C07C17/12C07C25/02
CPCC07C17/12C07C25/02
Inventor 刘定华王肖李景林陶文平王顺利赵晓龙
Owner NANJING UNIV OF TECH
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