Synthetic method of halogenated triazolopyridine
The technology of a halogenated triazolopyridine and a synthesis method is applied in the synthesis field of halogenated triazolopyridine, can solve problems such as low yield, and achieve the effects of simplifying purification steps, simplifying post-processing steps, and promoting heat dissipation
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Embodiment 1
[0062] A halogenated triazolopyridine, its concrete structural formula is:
[0063]
[0064] The synthetic method of above-mentioned a kind of halogenated triazolopyridine, the reaction equation of its synthetic process is as follows:
[0065]
[0066] The raw materials used in the above-mentioned synthesis reaction process and the corresponding raw material charging amount and charging ratio (the charging ratio is the amount of substance) are as follows:
[0067]
[0068] The synthetic method of above-mentioned a kind of halogenated triazolopyridine, the reaction steps of its synthetic process are as follows:
[0069] Synthesis of S1 compound of formula I-a:
[0070] 2-Amino-5-bromopyridine (15.0 g, 86.7 mmol) was added to isopropanol (320 ml) to obtain mixed solution A; DMF-DMA (12.4 g, 104.0 mmol) was added to mixed solution A to obtain mixed solution B; the mixed solution B is controlled to react at 85° C. under the conditions of reflux and mechanical stirring f...
Embodiment 2
[0078] A halogenated triazolopyridine, its concrete structural formula is:
[0079]
[0080] The synthetic method of above-mentioned a kind of halogenated triazolopyridine, the reaction equation of its synthetic process is as follows:
[0081]
[0082] The raw materials used in the above-mentioned synthesis reaction process and the corresponding raw material charging amount and charging ratio (the charging ratio is the amount of substance) are as follows:
[0083]
[0084]
[0085] The synthetic method of above-mentioned a kind of halogenated triazolopyridine, the reaction steps of its synthetic process are as follows;
[0086] Synthesis of S1 compound of formula I-b:
[0087] 2-Amino-4-bromopyridine (15.0 g, 86.7 mmol) was added to isopropanol (320 ml) to obtain mixed solution A; DMF-DMA (12.4 g, 104.0 mmol) was added to mixed solution A to obtain mixed solution B; the mixed solution B is controlled to react at 85° C. under the conditions of reflux and mechanica...
Embodiment 3
[0095]A halogenated triazolopyridine, its concrete structural formula is:
[0096]
[0097] The synthetic method of above-mentioned a kind of halogenated triazolopyridine, the reaction equation of its synthetic process is as follows:
[0098]
[0099] The raw materials used in the above-mentioned synthesis reaction process and the corresponding raw material charging amount and charging ratio (the charging ratio is the amount of substance) are as follows:
[0100]
[0101] The synthetic method of above-mentioned a kind of halogenated triazolopyridine, the reaction steps of its synthetic process are as follows;
[0102] Synthesis of S1 compounds of formula I-c:
[0103] 2-Amino-3-bromopyridine (15.0 g, 86.7 mmol) was added to isopropanol (320 ml) to obtain mixed solution A; DMF-DMA (12.4 g, 104.0 mmol) was added to mixed solution A to obtain mixed solution B; the mixed solution B is controlled to react at 85° C. under the conditions of reflux and mechanical stirring f...
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