Implantable gel photoelectrode and preparation method thereof

Abstract

The invention belongs to the technical field of multifunctional composite probe material preparation, and particularly discloses an implantable gel photoelectrode and a preparation method thereof.The method comprises the steps that S1, a high-molecular polymer solution is prepared to serve as a skin layer spinning solution; preparing a gel monomer solution as a first core layer spinning solution; preparing a carbon-based hybrid spinning solution as a second core layer spinning solution; s2, the spinning solution is extruded into a water bath of a coagulating bath through a double-core spinning nozzle, an ultraviolet point light source, the skin layer spinning solution, the second core layer spinning solution and the first core layer spinning solution are arranged to be cured and formed, then drying, winding, collecting and reducing are conducted, and the implanted gel photoelectrode is obtained. The preparation method disclosed by the invention has the advantages of continuity, controllable diameter and adjustable mechanical property; and the prepared implantable gel photoelectrode has excellent light guide property, electric conduction property and mechanical property capable of being highly matched with soft tissue. The preparation method is suitable for preparing the photoelectrode, and the prepared photoelectrode is suitable for optogenetics.

Description

technical field [0001] The invention belongs to the technical field of preparation of multifunctional composite probe materials, in particular to an implantable gel photoelectrode and a preparation method thereof. Background technique [0002] The optogenetic process mainly includes light stimulation and electrical feedback: the laser light is transmitted from the in vitro to the target tissue through the optode, and the ion channels of light-sensitive proteins such as channel rhodopsin-2 (ChR2) of the neurons are excited to open, thereby changing the internal and external potentials of the cell membrane, producing The electrophysiology can be detected by electrodes and then transferred to the in vitro instrument for analysis. In the above process, the distance between the optode and the electrode must be within the effective control range of the neuron, and it is difficult to accurately grasp the action distance of the traditional separated light and electrode. Therefore, ...

AI Technical Summary

Problems solved by technology

This serious mismatch of the mechanical properties of the photoelectrode / tissue interface will lead to two serious consequences: (1) Induce an inflammatory response and affect the long-term effect of optogenetics

(2) Cause device displacement and affect the accuracy of optogenetics

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