Preparation method of molecularly imprinted polymer based on curcumin, electrochemical sensor and application thereof
A technology of molecular imprinting and curcumin, applied in the field of detection, can solve problems such as affecting the universal applicability of experimental methods
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[0030] The present application prepares a biocompatible material that is easy to extract and separate curcumin through the self-polymerization of zein, which can effectively extract curcumin from any environment and raw material such as high temperature, low temperature, high pressure, and a large amount of organic solvents A novel molecularly imprinted polymer (MBMIP) for highly sensitive and selective determination of curcumin in complex samples was successfully constructed by combining zein with a curcumin template. As a functional monomer and cross-linking agent, zein reacts with templates to form microsphere polymers under mild conditions; zein can self-polymerize by changing the polarity of the solvent, thereby introducing magnetic Fe 3 O 4 Nanoparticles, molecularly imprinted polymers with specific adsorption and magnetic properties are obtained. Specifically, the embodiment of the present invention discloses a preparation method of a curcumin-based molecularly imprint...
Embodiment 1
[0051] 1Materials and Instruments
[0052] Curcumin (98%) was purchased from China Institute of Pharmaceutical and Biological Products, ferric chloride hexahydrate (FeCl 3 ·6H 2 O), anhydrous sodium acetate (NaAc), ethylene glycol (CH 2 OH) 2 , sodium citrate (Na 3 C 6 H 5 O 7 ·2H 2 O), hydrochloric acid (HCl), methanol (MeOH), anhydrous ethanol (EtOH), and acetic acid (AcOH) were purchased from Chengdu Kelong Chemical Reagent Factory (Chengdu), and acetonitrile (ACN) and methanol were obtained from Merck ) produced high performance liquid chromatography (HPLC) grade products, and the ultrapure water used in the experiment was prepared by the Millipore-q system of Millipore, Milford, MA, USA. All other reagents were analytical grade.
[0053] Scanning electron microscope (SEM) and transmission electron microscope (TEM) images were obtained with MERLIN Compact (ZEISS, Germany) and JEM 2100F (JEOL, Japan). Infrared spectra were obtained by near-infrared affinity Fourie...
Embodiment 2
[0068] Example 2 Verification and Analysis
[0069] 1 SEM and TEM patterns of MBMIPs, MBNIPs and Fe3O4NPs
[0070] MBMIPs ( figure 2 a), MBNIPs ( figure 2 b) and Fe 3 O 4 NPs( figure 2 c) The morphological features were characterized, such as figure 2 shown, by figure 2 It can be seen that Fe 3 O 4 The NPs are spherical, highly monodisperse, and have a diameter of 300 nm; the MBMIPs ( figure 2 d), MBNIPs ( figure 2 e) and Fe 3 O 4 NPs( figure 2 f) were characterized by their morphological features; scanning electron microscopy (SEM) and transmission electron microscopy (TEM) images showed that the MBMIPs were spherical structures with a diameter of 300–380 nm, compared with Fe 3 O 4The particle size of NPs increased significantly, it is speculated that zein has been successfully polymerized in Fe. 3 O 4 on the surface.
[0071] 2 Fe 3 O 4 FT-IR spectra of NPs, Zein and MBMIPs
[0072] FT-IR analysis confirmed the presence of zein in the nanoparticl...
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