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Column head and column tail structure for liquid phase chromatographic column with zero dead volume and fine inner diameter

A liquid chromatographic column and chromatographic column technology, applied in the field of column head/column tail structure, can solve problems such as column efficiency reduction and spectral band broadening.

Inactive Publication Date: 2004-11-03
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, when this structure is used in a packed capillary liquid chromatographic column with an inner diameter less than 2mm, the influence of the dead volume generated by the thicker filter and the dead volume R between the filter and the bottom of the two-way joint is very obvious.
After the sample enters the packed capillary column, it will reach the tube wall immediately. When the band moves to the joint between the column outlet and the joint, the gaps, dead zones and rough channels here will cause the band to broaden and the column efficiency to decrease.

Method used

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  • Column head and column tail structure for liquid phase chromatographic column with zero dead volume and fine inner diameter
  • Column head and column tail structure for liquid phase chromatographic column with zero dead volume and fine inner diameter
  • Column head and column tail structure for liquid phase chromatographic column with zero dead volume and fine inner diameter

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Embodiment 1

[0019] like figure 1 and figure 2 As shown, this embodiment is mainly composed of a connecting two-way a, a porous filter sheet e and an outlet pipe d, and the outlet pipe d includes a capillary tube b with a smooth inner wall and a flexible and chemically inert polytetrafluoroethylene material outside the capillary tube. The outer casing f and the chromatographic column g are stainless steel filled capillary liquid chromatographic columns, the end of which is inserted into one side of the connecting two-way a, and the other side is inserted into the outlet pipe d and the sleeve, and the two are fixed by the ferrule c and the nut i . The connecting two-way a is located between the two ferrules c, and there is an axial equal-diameter hole j. The diameter of the equal-diameter hole j is such that the chromatographic column g and the outlet tube d can be inserted in a tight fit, and the end of the chromatographic column g and the outlet tube d are placed between Porous filter...

Embodiment 2

[0021] The jacket f is made of polyetheretherketone material, the chromatographic column g is a polyetheretherketone (PEEK) filled liquid chromatographic column, the porous filter e is a stainless steel mesh filter, and the rest are the same as those in Example 1.

Embodiment 3

[0023] The jacket f is made of polyethyltrifluoroethylene material, the chromatographic column g is a stainless steel filled liquid chromatographic column, the porous filter e is a titanium alloy mesh filter, and the rest are the same as those in Example 1.

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Abstract

This invention provides a head / tail structure of zero dead volume fine inner diameter liquid phase chromatographic column comprising a connecting two-way, a multi-hole filter leaf and an outgoing tube in which the end of the chromatographic column plugs in one side of the connecting two-way and the other side is plugged in by the capillary and a barrel to be fastened by cutting sleeves and screw covers. The two-way forms an equal diameter hole between the two cutting sleeves and the multi-filter leaf placed between the butted joint end of the chromatographic column and the outgoing tube to form a sealed ring naturally at the joint sealing completely slots between the outer wall of the column tube and inner wall of the two way and slot between end of the capillary and sleeve tube.

Description

technical field [0001] The invention relates to a chromatographic technique, and particularly provides a column head / column tail structure of a zero dead volume thin inner diameter liquid chromatography column. Background technique [0002] Stainless steel-filled capillary liquid chromatography is a separation and analysis technology that has attracted much attention in recent years. Especially in recent two proteomics research, the combination of micro-column liquid chromatography and mass spectrometry is widely used, and further development of this related technology is urgently needed. Compared with conventional liquid chromatography, it has the advantages of low solvent consumption, low pollution, fast analysis speed, easy to use online with other detection methods, etc. At the same time, it has the characteristics of simple operation and convenient use. One of the promising separation analysis methods. But so far, the column efficiency of commercial stainless steel-pac...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01D15/08G01N30/02G01N30/60
Inventor 关亚风朱道乾唐意红
Owner DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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